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| 1 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 2 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 3 | Posterior partially edentulous jaws, planning a rehabilitation with dental implants显示文摘AIM: To discuss important characteristics of the useof dental implants in posterior quadrants and the rehabilitation planning. METHODS: An electronic search of English articles was conducted on MEDLINE(PubM ed) from 1990 up to the period of March 2014. The key terms were dental implants and posterior jaws, dental implants/treatment planning and posterior maxilla, and dental implants/treatment planning and posterior mandible. No exclusion criteria were used for the initial search. Clinical trials, randomized and non randomized studies, classical and comparative studies, multicenter studies, in vitro and in vivo studies, case reports, longitudinal studies and reviews of the literature were included in this review. RESULTS: One hundred and fifty-two articles met the inclusion criteria of treatment planning of dental implants in posterior jaw and were read in their entirety. The selected articles were categorized with respect to their context on space for restoration, anatomic considerations(bone quantity and density), radiographic techniques, implant selection(number, position, diameter and surface), tilted and pterygoid implants, short implants, occlusal considerations, and success rates of implants placed in the posterior region. The results derived from the review process were described under several different topic headings to give readers a clear overview of the literature. In general, it was observed that the use of dental implants in posterior region requires a careful treatment plan. It is important that the practitioner has knowledge about the theme to evaluate the treatment parameters. CONCLUSION: The use of implants to restore the posterior arch presents many challenges and requires a detailed treatment planning. | Douglas R Monteiro Emily V F Silva Eduardo P Pellizzer Osvaldo Magro Filho Marcelo C Goiato | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 4 | Rapid maxillary expansion in the deciduous and mixed dentition evaluated through posteroanterior cephalometric analysis显示文摘 | Da Silva Filho O G Montes I A Torelly I F | 1995 | Am J Orthod Dentofacial Or-thop1995，107，3： | 1 |
| 5 | A bovine pericardium rigid prosthesis for left ventricle restoration:12 years of follow-up显示文摘 | Silveira Filho LM Petrucci O Vilarinho KA Baker RS Garcia F Oliveira PP | | 0，，02： | 1 |
| 6 | An automated system for liquid - liquid extraction based on a new micro - batch extraction chamber with on - line detection Preconcentration and determination of copper ( Ⅱ ) 显示文摘 | DINIZ M C T FILHO O F ROHWEDDER J J R | 2004 | Anal Chim Acta2004，525，2： | 1 |
| 7 | Thermal properties of hybrid lignocelluloSiC fabric-reinforced polyester matrix composites显示文摘 | Alsina O L S CarvalhoL H de Filho F G R | 2005 | Polymer Testing2005，24，1： | 1 |
| 8 | Development, validation and application of a methodology based on solid-phase micro-extraction followed by gas chro- matography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes显示文摘 | MENEZES FILHO A DOS SANTOS F N PEREIRA P A P | 2010 | Talanta2010，81，1： | 1 |
| 9 | Nasal extra nodal T/NK cell lymphoma presenting as a palatal lesion: an uncommon clinical presentia- tion of a rare case显示文摘 | Filho F D Castro A J | 2015 | Egyptian of Journal Harematology2015，40，1： | 1 |
| 10 | Comparison of three single-phase PLL algorithms for UPS applications显示文摘 | Santos Filho R M Seixas P F Cortizo P C | 2008 | IEEE Transactions on Industrial Electronics2008，55，8： | 1 |
| 11 | Thermal properties of hybrid lignocellulosic fabric-reinforced polyester matrix composites显示文摘 | Alsina O L S Carvalho L H Filho F G R | 2005 | Polymer Testing2005，24，1： | 1 |
| 12 | Posttransplant Diabetes Mellitus: Incidence and Risk Factors 显示文摘 | Mazali F C Lalli C A Filho G A | 2008 | Transplant Proc2008，40，4： | 1 |
| 13 | Re-Os and Sm-Nd isotope and trace element constraints on the origin of the chromite deposit of the Ipueira-Medrado Sill, Bahia, Brazil 显示文摘 | Marques J C Ferreira Filho C F Carlson R W | 2003 | Journal of Petrology2003，44，4： | 1 |
| 14 | A Model of a Permanent Magnet Axial-Flux Machine Based on Lie's Symmetries 显示文摘 | Loureiro L T R Filho A F F Zabadal J R S | 2008 | IEEE Transactions on Magnetics2008，44，11： | 1 |
| 15 | Targeting key alteration minerals in epithermal deposits in Patagonia,Argentina,using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza Filho C R Azevedo F Brodie C | | 0，，21： | 1 |
| 16 | Cracking Mechanisms in Durable Sisal Fiber Reinforced Cement Composites显示文摘 | Silva F A Mobasher B Toledo Filho R D | | 0，，10： | 1 |
| 17 | Canoni- cal and noncanonical Wnt pathway : a comparison among normal ovary,benign ovarian tumor and ovarian cancer 显示文摘 | Badiglian Filho L Oshima CT De Oliveira Lima F | 2009 | Oncol Re- ports2009，21，2： | 1 |
| 18 | In- tranasal dexmedetomidine for sedation for pediatric computed tomography imaging显示文摘 | Mekitarian Filho E Robinson F De Carvalho WB | 2015 | J Pediatr2015，166，5： | 1 |
| 19 | Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC–MS) for the determination of pesticide residues in mangoes显示文摘 | Adalberto Menezes Filho Fábio Neves dos Santos Pedro Afonso de Paula Pereira | 2009 | Talanta2009，，1： | 1 |
| 20 | Application of neodymium-iron-boron permanent magnets on the assembling of a novel planar actuator显示文摘 | Aly F Flores Filho Altamiro A | 1999 | IEEE Transactions on Magnetics1999，35，5： | 1 |
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