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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 3 | Room temperature PL characterization of micro and nanocrystalline diamond grown by MPCVD from Ar/H2/CH4 mixtures 显示文摘 | NET() M A FERNANDES A J S SILVA R F | 2007 | Vacuum2007，81，： | 1 |
| 4 | Scandium in aluminum alloys 显示文摘 | KRAMER L S TACK W T FERNANDES M T | 1997 | Adv Mater Process1997，152，10： | 1 |
| 5 | Phytosterols : Applications and recovery methods 显示文摘 | Fernandes P Cabral J M S | 2007 | Bioresource Technology2007，98，12： | 1 |
| 6 | Comparative structural analysis of et-glucosidase inhibitors on difference species: a computational study 显示文摘 | Narayana Moorthy N S Ramos M J Fernandes P A | 2012 | Arch Pharm (Weinheim)2012，345，4： | 1 |
| 7 | Methodology comparison for canopy structure parameters extraction from digital hemispherical photography in boreal forests显示文摘 | Leblanc S G Chen J M Fernandes R | 2005 | Agricultural and Forest Meteorology2005，129，： | 1 |
| 8 | Glycemic index of potatoes commonly consumed in North America显示文摘 | FERNANDES G VELANGI A WOLEVER T M S | 2005 | Journal of the American Dietetic Association2005，105，： | 1 |
| 9 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 10 | The effects of the sumter wastewater treatment plant on the survival and reproduction of Ceriodaphnia dubia in chronic toxicity tests 显示文摘 | WORLEY E FERNANDES P R HARMON S M | 2010 | Journal of the South Carolina Academy of Science2010，8，1： | 1 |
| 11 | High performance sea- ling with CVD diamond self-mated rings 显示文摘 | Tome M A Fernandes A J S | 2005 | Diamond Rela- ted Mater2005，14，： | 1 |
| 12 | Distributedcontrol to ensure proportional load sharing and improve voltageregulation in low voltage DC microgrids 显示文摘 | ANAND S FERNANDES B GfGUERRERO J M | 2013 | IEEE Transactionson Power Electronics2013，28，4： | 1 |
| 13 | Scandium in aluminum alloys显示文摘 | Kramer L S Tack W T Fernandes M T | 1997 | Adv Mater & Proc1997，152，4： | 1 |
| 14 | Wear resistant CVD diamond tools for turning of sintered hardmetals 显示文摘 | Belmonte M Ferro P Fernandes A J S | 2003 | Diamond and related materials2003，，12： | 1 |
| 15 | The effect of an infusion of esmolol on the incidence of myocardial ischaemia during tracheal extubation following coronary artery surgery显示文摘 | Kurian S M Evans R Fernandes N O | 2001 | Anaesthesia2001，56，12： | 1 |
| 16 | Genetic elements in the VP re- gion of porcine parvovirus are critical to replication efficiency in cell culture 显示文摘 | Fernandes S Boisvert M Tijssen P | 2011 | J Virol2011，85，6： | 1 |
| 17 | Gas chromatographic-mass spectrometric quantification of 4-(5- )- methylimidazole in roasted coffee after ion-pair extraction 显示文摘 | S Casal J O Fernandes M B P P Oliveira | 2002 | Journal of Chromatography A2002，976，： | 1 |
| 18 | The influence of sea- sonal signals on the estimation of the tectonic motion in short continuous GPS time-series 显示文摘 | Bos M S Bastos L Fernandes R M S | 2010 | Journal of Geodynamics2010，49，3： | 1 |
| 19 | Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short chain fatty acids and microbiota显示文摘 | Schneider S M Fernand G P Rodolphe A | 2006 | Clinic Nutrition2006，25，： | 1 |
| 20 | Mathematical model coupling phased transformation and temperature evolution dur- ing quenching of steels 显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technolo- gy1985，1，10： | 1 |
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