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| 1 | Predictive biomarkers in precision medicine and drug development against lung cancer显示文摘The molecular characterization of various cancers has shown that cancers with the same origins,histopathologic diagnoses,and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis.A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified.Therapeutic agents targeting some of these cancer drivers have been successfully developed,resulting in substantial improvements in clinical symptom amelioration and outcomes in a subset of cancer patients.However,because such therapeutic drugs often benefit only a limited number of patients,the successes of clinical development and applications rely on the ability to identify those patients who are sensitive to the targeted therapies.Thus,biomarkers that can predict treatment responses are critical for the success of precision therapy for cancer patients and of anticancer drug development.This review discusses the molecular heterogeneity of lung cancer pathogenesis;predictive biomarkers for precision medicine in lung cancer therapy with drugs targeting epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),c-ros oncogene 1 receptor tyrosine kinase[ROSl),and immune checkpoints;biomarkers associated with resistance to these therapeutics;and approaches to identify predictive biomarkers in anticancer drug development.The identification of predictive biomarkers during anticancer drug development is expected to greatly facilitate such development because it will increase the chance of success or reduce the attrition rate.Additionally,such identification will accelerate the drug approval process by providing effective patient stratification strategies in clinical trials to reduce the sample size required to demonstrate clinical benefits. | Bingliang Fang Reza J Mehran John V Heymach Stephen G Swisher | 2015 | Chinese Journal of Cancer2015，34，7： | 5 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5huovuxn6u9p0w6nc0.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | 显示文摘 | Fang J Raymond L V | 1978 | J Colloid Interface Sei1978，116，： | 1 |
| 5 | Stock market liquidity and firm value 显示文摘 | Fang V W Noe T H Tice S | 2009 | Journal of Financial Economics2009，94，1： | 1 |
| 6 | Stable carbon isotope biogeochemistu of a shallow sand aquifer contam- inated with fuel hydrocarbons显示文摘 | Fang J S Barcelona M J Krishnamurthy R V | 2000 | Applied Geochemistry2000，15，2： | 1 |
| 7 | Conductivity study of the microemuIsion system sodium dodecyl sulfate - hexylamine - heptane - water 显示文摘 | FANG J RAYMONDL V | 1978 | Colloid Inter Sci1978，116，： | 1 |
| 8 | Network embeddedness and technology transfer performance in R&D consortia in Taiwan 显示文摘 | Lin J L Fang S-C Fang S-R V | 2009 | Technovation2009，29，11： | 1 |
| 9 | Echocardiographic detection of early diabetic myocardial disease显示文摘 | Fang ZY Yuda S Anderson V | 2003 | J Am Coll Cardiol2003，41，4： | 1 |
| 10 | IGF-I in human growth: lessons from defects in the GH-IGF-I Axis 显示文摘 | Hwa V Fang P Derr M A | 2013 | Nestl Nutr Inst workshop ser2013，71，： | 1 |
| 11 | Quantum-behaved particle swarm optimization with Gaussian distributed local attractor point显示文摘 | Sun J Fang W Palade V | | 0，，07： | 1 |
| 12 | Predictors of self-re- ported health-related quality of life in systemic lupus er- ythematosus显示文摘 | Kiani A N Strand V Fang H | 2013 | Rheumatology (Oxford)2013，52，9： | 1 |
| 13 | FDA-approved drug labeling for the study of drug-induced liver injury显示文摘 | Chen M Vijay V Shi Q Liu Z Fang H Tong W | 2011 | Drug Discov Today2011，16，1516： | 1 |
| 14 | An analysis of grain boundaries and grain growth in cemented tungsten carbide using orientation imaging microscopy 显示文摘 | Kumar V Fang Z Z Wright S I Nowell M M | 2006 | Metall Mater Trans2006，37，： | 1 |
| 15 | Air pollution and associated human mortality:The role of air pollutant emissions,climate change and methane concentration increases from the preindustrial period to present显示文摘 | Fang Y Naik V Horowitz LW | 2013 | Atmospheric Chemistry and Physics2013，13，3： | 1 |
| 16 | A hierarchical neural network approach to the development of a library of neural models for microwave design显示文摘 | Wang Fang Devabhaktuni V K Zhang Q J | 1998 | IEEE Trans MTT1998，46，12： | 1 |
| 17 | Suppressed gene expressi on of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty aci ds显示文摘 | Juan C C Au L C Fang V S | 2001 | Biochem Biophys Res Commun2001，289，： | 1 |
| 18 | Quasi - analytical approximations and series in electro-magnetic modeling 显示文摘 | ZHDANOV M S DMITRIEV V I FANG S | 2000 | Geophysics2000，65，6： | 1 |
| 19 | Echocardiographic detection of early diabetic myocardial dise&se显示文摘 | Fang ZY Yuda S Anderson V | 2003 | J Am Coll Cardiol2003，41，4： | 1 |
| 20 | Flexural subsidence by 29 Ma on the NE edge of Tibet from the magnetostratigraphy of Linxia Basin,China显示文摘 | Fang X M Carmala G Rob V | 2003 | Earth and Planetary Science Letters2003，210，： | 1 |
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