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| 1 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Preliminary study offlavonols in port wine grape varieties 显示文摘 | ANDRADE P B MENDES G FALCO V | 2001 | Food Chem2001，73，4： | 1 |
| 4 | Structure and function of pla- centa growth factor 显示文摘 | De Falco S Gigante B Persico MG | 2002 | Trends Cardiovasc Med2002，12，6： | 1 |
| 5 | Calibration transfer in chemiluminescence analysis application to chromium determination by luminol-hydrogen peroxide reaction显示文摘 | TORTAJADA L A FALCO P C REIG F B | 2001 | Analytica Chimica Acta2001，446，： | 1 |
| 6 | Stucture and function of placental growth factor显示文摘 | De Falco S Gigante B Persico MG | 2002 | Trends Cardiovasc Med2002，12，6： | 1 |
| 7 | Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis显示文摘 | Rigano R Buttari B De Falco E | 2004 | Parasit Immunol2004，26，： | 1 |
| 8 | Microcolposcopic topograthic endocervical assessment before excisional treatment of cervical intraepithelial neoplasia 显示文摘 | Guerra B Guida G Falco P | 1998 | Obstet Gynecol1998，88，1： | 1 |
| 9 | The inherent quantitative capacity of the reverse transcription-polymerase chain reaction显示文摘 | Halford W P Falco V C Gebhardt B M | 1999 | Anal Biochem1999，266，： | 1 |
| 10 | Structure and function of placental growth factor显示文摘 | de Falco S Gigante B Persico MG | 2002 | Trends Cardiovasc Med2002，12，6： | 1 |
| 11 | Health risks of dietary intake of environmental pollutants by elite sportsmen and sportswomen 显示文摘 | FALCO G BOCIO B A LLOBET J M | 2005 | Food and Chemical Toxicology2005，，43： | 1 |
| 12 | Structure and function of placental growth factor显示文摘 | De Falco S Gigante B Persico MG | 2002 | Trends Cardiovasc Med2002，12，6： | 1 |
| 13 | Human NK cells directly recognize Mycobacterium boris via TLR2 and acquire the ability to kill monocyte-derived DC 显示文摘 | Marcenaro E Ferranti B Falco M | 2008 | Int Immunol2008，20，9： | 1 |
| 14 | The production of hydrogen sulphide and other aroma compounds by wine strains ofSaccharomyces cerevisiae in synthetic media with different nitrogen concentrations显示文摘 | Mendes-Ferreira A Catarina B Falco V | 2009 | Journal of Industrial Microbiology2009，36，4： | 1 |
| 15 | The inherent quantitative capacity of the reverse transcription polymerase chain reaction 显示文摘 | Halford W P Falco V C Gebhardt B M | 1999 | Analysis Biochemistry1999，266，2： | 1 |
| 16 | A novel el wthroid anion exchange variant (Gly796Arg) of heredita~ stoma- tocytosis associated with dyserythropoiesis 显示文摘 | Achille I Luigia De Falco Franck B | 2009 | Haemato- logiea2009，，8： | 1 |
| 17 | The inherent quantitative capacity of the reverse transcription-polymerase chain reaction显示文摘 | Halford W P Falco V C Gebhardt B M | 1999 | Analytical Biochemistry1999，266，2： | 1 |
| 18 | Structure and function of placental growth factor 显示文摘 | De Falco S Gigante B Persico MG | 2002 | Trends Gardiovasc Med2002，12，6： | 1 |
| 19 | A Chemometric Study of the Simultaneous Determination of Calcium and Magnesium in Natural Waters显示文摘 | GOMEZ F B REIG F B FALCO P C | 1999 | Talanta1999，49，： | 1 |
| 20 | Complications of nativearteriovenous fistula: the role of color Doppler ultrasonography 显示文摘 | Visciano B Riccio E De Falco V | 2014 | TherApherDial2014，18，2： | 1 |
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