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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Encapsulation of enzymes in mesoporous host materials via the nonsurfactant- templated sol-gel process 显示文摘 | Wei Y Xu J G Feng Q W | 2000 | Materials Letters2000，44，1： | 1 |
| 3 | Analysis and design for a class of complex control systems, Part Ⅱ: fuzzy controller design显示文摘 | CAO S G REES N W FENG G | 1997 | Automatica1997，33，： | 1 |
| 4 | Further results about quadratic stability of continuous-time fuzzy control systems显示文摘 | Cao S G Rees N W Feng G | 1997 | System Science1997，28，4： | 1 |
| 5 | The BLUE Active Queue Management Algorithms显示文摘 | Feng W Shin K G Kandlur D D | 2002 | ACM Transactions on Networking2002，，10： | 1 |
| 6 | The structural and magnetic properties of Mn2 xFexNiGa Heusler alloys显示文摘 | LUO H Z MENG F B FENG Z Q LI Y X ZHU W WU G H ZHU X X JIANG C B XU H B | 2010 | J Appl Phys2010，107，01： | 1 |
| 7 | Rapamycin alleviates brain edema af- ter focal cerebral ischemia reperfusion in rats 显示文摘 | Guo W Feng G Miao Y | 2014 | Immunopharmacol Immunotoxico12014，36，3： | 1 |
| 8 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 9 | Spatiotemporal evolution of focused single-cycle electromagnetic pulses显示文摘 | Feng S Winful H G Hellwarth R W | 1999 | Phys Rev E1999，59，： | 1 |
| 10 | Spectral clustering with discriminant cuts显示文摘 | CHEN W FENG G | 2012 | Knowledge-Based Systems2012，28，： | 1 |
| 11 | A new differential scheme with multi-time levels 显示文摘 | DONG W J CHOU J F | 2001 | Chinese Physics2001，10，11： | 1 |
| 12 | Human exposure to methylmercury through rice intake in mercury mining areas, Guizhou prov?ince, China显示文摘 | Feng X Li P Qiu G Wang S Li G Shang L Meng B Jiang H Bai W Li Z Fu X | 2008 | Environ Sci Technol2008，42，1： | 1 |
| 13 | Crystal structure of bis ( homophthalato ) -bis dicadmium ( 11 ) , Cd2 ( C9H604 )2 ( Cl6- n,4 N4 )2 显示文摘 | Zhao W X Wen P H Feng G D | 2010 | NCS2010，225，3： | 1 |
| 14 | Distribution of Al and adsorption of NH3 and pyridine in ZSM-12: A computational study显示文摘 | FENG G LIAN Y Y YANG D Q LIU J W KONG D J | 2013 | Can J Chem2013，91，10： | 1 |
| 15 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 16 | An approach to control of a class of nonlinear systems显示文摘 | FENG G CAO S REES W | 1996 | Automatica1996，32，10： | 1 |
| 17 | Synthesis of nano-scale silicon wires by exciter laser ablation at high temperature 显示文摘 | Yu D P Lee C S Bello I Sun X S Tang Y H Zhou G W Bai Z G Zhang Z Feng S Q | 1998 | Solid State Communication1998，105，6： | 1 |
| 18 | Theoretical Study on the Third-order Nonlinear Optical Properties of a Series of Derived 9, 9′-Spirobifluorenes显示文摘 | Fu W Feng J K Pan G B | 2001 | Journal of Molecular Structure (Theochem)2001，545，： | 1 |
| 19 | Analysis and design for a complex control system, part I: fuzzy modeling and identification显示文摘 | Cao S G Rees N W Feng G | 1997 | Automatica1997，6，： | 1 |
| 20 | Design of Fuzzy Control Systems with Guaranteed Stability 显示文摘 | Feng G Cao S G Ress N W | 1997 | Fuzzy Sets and Systems1997，85，1： | 1 |
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