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| 1 | Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis显示文摘Peritonitis continues to be a major complication of peritoneal dialysis(PD), and adequate treatment is crucial for a favorable outcome. There is no consensus regarding the optimal therapeutic regimen, and few prospective controlled studies have been published. The objective of this manuscript is to review the results of PD peritonitis treatment reported in narrative reviews, systematic reviews, and proportional meta-analyses. Two narrative reviews, the only existing systematic review and its update published between 1991 and 2014 were included. In addition, we reported the results of a proportional metaanalysis published by our group. Results from systematic reviews of randomized control trials(RCT) and quasiRCT were not able to identify any optimal antimicrobial treatment, but glycopeptide regimens were more likely to achieve a complete cure than a first generation cephalosporin. Compared to urokinase, simultaneous catheter removal and replacement resulted in better outcomes. Continuous and intermittent IP antibiotic use had similar outcomes. Intraperitoneal antibiotics were superior to intravenous antibiotics in reducing treatment failure. In the proportional meta-analysis of RCTs and the case series, the resolution rate(86%) of ceftazidime plus glycopeptide as initial treatment was significantly higher than first generation cephalosporin plus aminoglycosides(66%) and glycopeptides plus aminoglycosides(75%). Other comparisons of regimens used for either initial treatment or treatment of gram-positive rods or gramnegative rods did not show statistically significant differences. The superiority of a combination of a glycopeptide and a third generation cephalosporin was also reported by a narrative review study published in 1991, which reported an 88% resolution rate. | Pasqual Barretti Joo Vitor Pereira Doles Douglas Gonalves Pinotti Regina Paolucci El Dib | 2015 | World Journal of Nephrology2015，4，2： | 9 |
| 2 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 3 | Impact of treated wastewater irrigation on quality attributes and contamination of tomato fruit显示文摘 | O Al-Lahham N.M El Assi M Fayyad | 2002 | Agricultural Water Management2002，，1： | 3 |
| 4 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 5 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 6 | Cluster analysis and display of genome-wide expression paltems显示文摘 | M Beisen P T Spellman P O Brown el al | 1998 | Proc Natl Acad Sci USA1998，95，14： | 1 |
| 7 | Inspiratory muscle training in adults with obstructive pulmonary disease: An update of a systematic review显示文摘 | Geddes EL O'Brien K Reid WD | 2008 | Respir Med2008，102，12： | 1 |
| 8 | Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans 显示文摘 | Hortobagyi T Dempsoy L Fraser O et el | 2000 | J Physiol2000，524，1： | 1 |
| 9 | Improved progression- free and overall survival in advanced ovarian cancer as a result of a change in surgical paradigm显示文摘 | Chi DS Eisenhauer EL Zivanovic O | 2009 | Gynecol Onco12009，114，1： | 1 |
| 10 | Mortality and cardiovascular events in patients treated witII homocysteine-lowering B vitamins after coronary angiography:a randomized controlled trial显示文摘 | Ebbing M Bleie O Ueland PM el al | 2008 | JAMA2008，300，7： | 1 |
| 11 | Murray river water,raised cyanobacterial counts and gastrointestinal and dermatological symptoms显示文摘 | El Saadi O Esterman A J Cameron S | 1995 | Medical Journal of Australia1995，162，： | 1 |
| 12 | The role of fringing coral reef in beach protection of Hurghada, Gulf of Suez, Red Sea of Egypt显示文摘 | Frihy O E El Ganaini M A El Sayed W R | 2004 | Ecological Engineering2004，22，1： | 1 |
| 13 | Efficient oxidative folding of conotoxins and the radiation of venomous cone snails 显示文摘 | Bulaj G Buczek O Goodsell I el at | 2003 | Proe Nad Aead Sei USA2003，100，14： | 1 |
| 14 | Skin-sparing mastectamy and immediate breast reconstruction显示文摘 | Vlastos G Elias B Meyer O el el | 2007 | Ball Cancer2007，94，9： | 1 |
| 15 | Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 of Rb oligonucleotides 显示文摘 | Hatzfeld J Li ML Brown EL Sookdeo H Levesque JP O′Toole T | 1991 | JExp Med1991，174，4： | 1 |
| 16 | An internally replicated quasi-experimental comparison of checklist and perspective-based reading of code documents显示文摘 | Laitenberger O El Emam K Harbich T | 2001 | IEEE Transactions on Software Engineering2001，27，5： | 1 |
| 17 | Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome显示文摘 | O' Brien TJ So EL Mullan BP | 2000 | Neurology2000，55，11： | 1 |
| 18 | MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL 显示文摘 | O' Sullivan M Jarosz JM Martin RJ el al | 2001 | Neurology2001，56，5： | 1 |
| 19 | Functional mapping of neurons that control loco motory behavior in Caenorhabditis elegans显示文摘 | Tsalik EL Hobret O | 2003 | J Neurobiol2003，56，： | 1 |
| 20 | Endoscopic plantar fascia release,calca-neal drilling and calcaneal spur removal for management of painfulheel syndrome 显示文摘 | El Shazly O El Beltagy A | 2010 | Foot(Edinb)2010，20，4： | 1 |
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