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| 1 | Great flood in the middle-lower Yellow River reaches at 4000 a BP inferred from accurately-dated stalagmite records显示文摘Recently,Wu et al.[1]suggested an earthquake-induced landslide dam outburst flood on the eastern Tibetan Plateau at 1920BCE(3870 a BP,BP denotes year before 1950 CE)caused the Great Flood in the middle-lower Yellow River reaches,and resulted in the founding of Xia Dynasty at 3850 a BP.This age is$150–300younger than the previously estimated age of the Xia Dynasty[2].While the geological evidence of the outburst flood。 | Liangcheng Tan Chuan-Chou Shen Yanjun Cai Hai Cheng R.Lawrence Edwards | 2018 | Science Bulletin2018，63，4： | 16 |
| 2 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 3 | Application of Avaatech X-ray fluorescence core-scanning in Sr/Ca analysis of speleothems显示文摘Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca. | Dong LI Liangcheng TAN Fei GUO Yanjun CAI Youbin SUN Gang XUE Xing CHENG Hong YAN Hai CHENG R.Lawrence EDWARDS Yongli GAO Jessica KELLEY | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 4 | The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles显示文摘Aptamer guided nano medicine shows great promise in targeted cancer therapies.However the loss of targeting capacity duri ng in vivo or clinical trials has largely hindered its popularity and there are no systematic studies to elucidate the causes.Herein,we investigated such loss of targeting capacity by examining how the physiological milieu affected targeting effect.Aptamer functionalized gold nanoparticle(AuNP)was chosen as the model and exposed to human blood serum that is used to mimic physiological milieu.Dynamic light scattering(DLS),flow cytometry and label-free liquid chromatography tan dem mass spectrometry(LC-MS/MS)were employed to determi ne variations of NPs'surface chemistry and biological identities changes after serum exposure.Results showed that the targeting ability loss was caused by protein corona blocking,replacement and enzymatic cleavage of surface aptamer targeting ligands.Noteworthy,the aggregation issue is critical for the smaller NPs.Analysis of the protein corona profile indicated the accumulation of immune-related proteins on the surface of aptamer-conjugated NPs,which could induce immune response,resulting in rapid clearanee of NPs. | Ding Ding Yinling Zhang Edward A.Sykes Long Chen Zhuo Chen Weihong Tan | 2019 | Nano Research2019，12，1： | 2 |
| 5 | COMPARISON OF HEAVY METAL CONCENTRATIONS IN SURFACE SEDIMENT OF TANJUNG PIAI WETLAND WITH OTHER SITES RECEIVING ANTHROPOGENIC INPUTS ALONG THE SOUTHWESTERN COAST OF PENINSULAR MALAYSIA显示文摘S:Tanjung Piai wetland has now been proclaimed to be a wetland of international importance since 2003. Therefore, its heavy metal pollution status should be known and recorded. In this study, sediments in Tanjung Piai wetland were collected in 2002 and 2005 and were analysed for Cd, Cu, Ni, Pb and Zn. For comparison purpose, sediments were also collected for metal analysis from a known polluted site at Kg. Pasir Puteh, four jetties and a river. A comparison with the polluted sediment collected from Kg. Pasir Puteh and the established Sediment Quality Criteria showed that Tanjung Piai was not polluted with Cd, Cu, Ni, Pb and Zn. These background concentrations or baseline data of heavy metals in the sediment is important for future reference. Therefore, Tanjung Piai wetland is a suitable site for sanctuary and wetland conservation and it should be conserved for its pristine conditions in order to support its high biodiversity. | Chee Kong Yap Mew Seong Choh Franklin Edward Berandah Ahmad Ismail Soon Guan Tan | 2006 | 湿地科学2006，4，1： | 2 |
| 6 | The variation of summer monsoon precipitation in central China since the last deglaciation显示文摘 | Yanjun Cai Liangcheng Tan Hai Cheng Zhisheng An R. Lawrence Edwards Megan J. Kelly Xinggong Kong Xianfeng Wang | 2009 | Earth and Planetary Science Letters2009，，1： | 2 |
| 7 | Robust fault reconstruction in uncertain lin- ear systems using multiple sliding mode observers in cascade 显示文摘 | Tan C P Edwards C | 2010 | IEEE Transactions on Automatic Control2010，55，4： | 1 |
| 8 | Petrogenesis of the Pt-Pd mineralized Jinbanshan ultramaflc intrusion in the Permian Emeishan Large Igneous Province, SW China 显示文摘 | Tan Yan Li Chu-si Hu Rui-zhong Edward M-R Du An-dan Zhaong Hong | 2006 | Contrib Mineral Petrol2006，153，： | 1 |
| 9 | Sliding mode estimation schemes for incipient sensor faults 显示文摘 | Alwi H Edwards C Tan C P | 2009 | Automatica2009，45，7： | 1 |
| 10 | Sliding mode observers for robust detection and reconstruction of actuator and sensor faults显示文摘 | TAN C P EDWARDS C | 2003 | International Journal Robust and Nonlinear Control2003，13，5： | 1 |
| 11 | Sliding mode observers for detection and reconstruction sensor faults 显示文摘 | TAN C P EDWARDS C | 2002 | Automati- ca2002，38，10： | 1 |
| 12 | Sliding mode observers for robust detection and reconstruction of actuator and sensor faults显示文摘 | TAN C P EDWARDS C | 2003 | Int J Robust Nonlinear Control2003，13，5： | 1 |
| 13 | Sliding mode observersfor detection and reconstruction ofsensorfaults显示文摘 | Tan C P Edwards C | 2002 | Automatica2002，38，10： | 1 |
| 14 | New results in robust actuator fault reconstruction for linear uncertain systems using sliding mode ob-servers显示文摘 | NG K Y TAN C P EDWARDS C | 2007 | International Journal Robust and Nonlinear Control2007，17，4： | 1 |
| 15 | Sliding mode observers for detection and reconstruction of sensor faults显示文摘 | Tan C P Edwards C | 2002 | Automatica2002，38，： | 1 |
| 16 | Robust fault reconstruction in uncertain linear systems using multiple sliding mode observers in cascade显示文摘 | Tan C P Edwards C | 2013 | IEEE Trans on Automatic Control2013，55，4： | 1 |
| 17 | Sliding mode observers for robust detection and reconstruction of actuator faults显示文摘 | Tan C P Edwards C | 2003 | Int J of Robust Nonlinear Control2003，13，5： | 1 |
| 18 | Sensor fault tolerant control using sliding mode observers 显示文摘 | Edwards C Tan C P | 2006 | Control Engineering Practice2006，14，8： | 1 |
| 19 | Sensor fault tolerant control using sliding mode observers显示文摘 | EDWARDS C TAN C P | | 0，，8： | 1 |
| 20 | A test of climate, sun, and culture relationships from an 1810-year Chinese cave record显示文摘 | Zhang P Z Cheng H Edwards R L Chen F H Wang Y J Yang X L Liu J Tan M Wang X F Liu J H An C L Dai Z B Zhou J Zhang D Z Jia J H Jin L Y Johnson K R | 2008 | Science2008，322，5903： | 1 |
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