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1Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732).Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco 2012World Journal of Gastroenterology2012,18,26:6
2Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study显示文摘Ana Ignjatovic James E East Noriko Suzuki Margaret Vance Thomas Guenther Brian P Saunders 2009Lancet Oncology2009,,:2
3Thinking Outside the Black Box: The Importance of Context in Understanding the Impact of a Preoperative Education Nursing Intervention among Chi- nese Cardiac Patients显示文摘Guo P East L Arthur A 2014Patient Educ Couns2014,95,3:1
4Differences in magnitude and duration of opiod induced respiratory depression and analgesia with fentanyl and sufentanil 显示文摘BAILEY P L STREISAND J B East K A 1990Anesth Analg1990,70,1:1
5Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukemia 显示文摘Dixon-Mclver A East P Mein CA 2008PLoS ONE2008,3,5:1
6Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity 显示文摘East JE Suzuki N Bassett P 2008Endoscopy2008,40,10:1
7Prescription products Moraxen sup- positories 显示文摘Schwarz P Schwarz H East S 2000The Pharmaceutical Journal2000,265,:1
8cDNA cloning of a salivary chymotrypsin-like protease and the identification of six additional cDNAs encoding putative digestive proteases from the green mirid, Creontiades dilutus (Hemiptera: Miridae)显示文摘COLEBATCH G Cooper P East P 2002Insect Biochem Mol Biol2002,,32:1
9HMGA2 functions as a competing endogenous RNA to promote lung cancer progression 显示文摘Kumar MS Annenteros-Monterroso E East P 2014Nature2014,505,7482:1
10Distinctive patterns of mi- croRNA expression associated with karyotype in acute myeloid leukaemia 显示文摘Dixon - McIver A East P Mein CA 2008PLoS One2008,3,5:1
11Recovery of submerged plants from high water stress in a large subtropical lake in Florida,USA显示文摘 Sharfstein B Brady M A East T L Harwell M C Maki R P Rodusky A J 2004Aquat Bot2004,78,:1
12Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil显示文摘Bailey P L Streisand J B East K A 1990Anesth analg1990,70,:1
13Differences in magnitude and duration of opioid-induced respiratory de-pression and analgesia with fentanyl and sufentanil显示文摘Bailey P L Streisand J B East K A 0,,01:1
14The effects of shading on morphometric and meristic characteristics of wild celery,Vallisneria americana,transplants from Lake Okeechobee,Florida显示文摘 Havens K E Sharfstein B Steinman A Anson D East T Maki R P Rodusky A Jin K R 2002Arch Hydrobiol2002,155,:1
15Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil显示文摘 Streisand J B East K A 1990Anesth Analg1990,70,1:1
16Dynamic patient position changes during colonoscope withdrawal increase adenoma detection: a randomized, crossover trial 显示文摘East JE Bassett P Arehi N 2011Gastrointest Endosc2011,73,3:1
17Differences in magnitude and duration of opioid - induced respiratory depression and analgesia with fentanyl and sufentanil 显示文摘BAILEY P L STREISAND J B EAST K A 1990Anesth Analg1990,70,1:1
18Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil显示文摘Bailey P L Streisand J B East K A 1990Anesth analg1990,70,:1
19Prescription products Moraxen suppositories 显示文摘Schwarz P Schwarz H East S 2000The Pharmaceutical Journal2000,265,:1
20Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil 显示文摘Bailey P L Streisand J B East K A 1990Anesth Analg1990,70,1:1
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