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| 1 | Gearbox Fault Diagnosis using Adaptive Zero Phase Time-varying Filter Based on Multi-scale Chirplet Sparse Signal Decomposition显示文摘When used for separating multi-component non-stationary signals, the adaptive time-varying filter(ATF) based on multi-scale chirplet sparse signal decomposition(MCSSD) generates phase shift and signal distortion. To overcome this drawback, the zero phase filter is introduced to the mentioned filter, and a fault diagnosis method for speed-changing gearbox is proposed. Firstly, the gear meshing frequency of each gearbox is estimated by chirplet path pursuit. Then, according to the estimated gear meshing frequencies, an adaptive zero phase time-varying filter(AZPTF) is designed to filter the original signal. Finally, the basis for fault diagnosis is acquired by the envelope order analysis to the filtered signal. The signal consisting of two time-varying amplitude modulation and frequency modulation(AM-FM) signals is respectively analyzed by ATF and AZPTF based on MCSSD. The simulation results show the variances between the original signals and the filtered signals yielded by AZPTF based on MCSSD are 13.67 and 41.14, which are far less than variances (323.45 and 482.86) between the original signals and the filtered signals obtained by ATF based on MCSSD. The experiment results on the vibration signals of gearboxes indicate that the vibration signals of the two speed-changing gearboxes installed on one foundation bed can be separated by AZPTF effectively. Based on the demodulation information of the vibration signal of each gearbox, the fault diagnosis can be implemented. Both simulation and experiment examples prove that the proposed filter can extract a mono-component time-varying AM-FM signal from the multi-component time-varying AM-FM signal without distortion. | WU Chunyan LIU Jian PENG Fuqiang YU Dejie LI Rong | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 16 |
| 2 | One-way wave equation seismic prestack forward modeling with irregular surfaces显示文摘数学地震检波器(MG )(et ) 并且相等时间的叠原则被用来实现向前用单程的声学的波浪方程与不规则的表面当模特儿的地震 prestack。这个方法从表面下的使用受到地震主要思考一套虚拟 MG。接收装置能位于在任何地方不规则的观察表面。而且, ETS 方法利用单程的声学的波浪方程到容易并且快速想象并且外推地震思考数据。方法用普通射击集合由二个简单模型,的数字前面的建模计算了的高单个噪音的比率被说明有扁平的表面的和有不规则的表面的,和复杂正常指责模型。为不规则的表面地形学的一个 prestack 深度迁居方法被用来与高精确性复制正常差错模型。 | Xiong Xiaojun He Zhenhua Huang Deji | 2006 | Applied Geophysics2006，3，1： | 9 |
| 3 | The role of mechanical stretch and TGF-β2 in epithelial-mesenchymal transition of retinal pigment epithelial cells显示文摘AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RPE) cells. METHODS: Human RPE cells were inoculated on BioF ex 6-well plates and RPE cells received 0, 1, 2, 3, or 4 mild stretch injuries delivered 3h apart after 24h of culture. The device of mechanical stress parameters were set to sine wave, frequency 1 Hz, stretch strength 20%. For treatment with TGF-β2, when the inoculated RPE cells in 6-well plates were around 60% confluent, serum was reduced to 0 for 12h and recombinant human TGF-β2(0, 1, 5, 10 ng/mL)was added for 48h. α-SMA, Vimentin and N-Cadherin, fibronectin proteins expressions were detected by Western blotting, confocal cell immunofluorescence and quantitative real-time polymerase chain reaction(q RT-PCR). Then we detected the change of mi RNA-29b and ascertained the changes of phosphatidylinositol 3-kinase-serine threonine protein kinase(PI3K/Akt) pathway after RPE cells were stretched by the device of mechanical stress and induced by TGF-β2 by Western blotting, confocal cell immunofluorescence and qR T-PCR. RESULTS: Mechanical stress induce EMT and activate the PI3K/Akt pathway in ways that lead to the EMT process. TGF-β2 induce RPE cells EMT and in a certain range and TGF-β2 decrease the miR NA-29b expression in RPE cells, and the inhibitory effect is more obvious with the increase of TGF-β2 concentration. CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and mi RNA-29b in pathogenesis of proliferative vitreoretinopathy(PVR) which may be a potential target for preventing or treating PVR. | Qian Cao Qu-Zhen Deji Ya-Jun Liu Wei Ye Wang-Dui Zhaba Qin Jiang Feng Yan | 2019 | International Journal of Ophthalmology(English edition)2019，12，12： | 9 |
| 4 | An integrated chemical mass balance and source emission inventory model for the source apportionment of PM2.5 in typical coastal areas显示文摘The source apportionment of PM2.5 is essential for pollution prevention.In view of the weaknesses of individual models,we proposed an integrated chemical mass balancesource emission inventory(CMB-SEI)model to acquire more accurate results.First,the SEI of secondary component precursors(SO2,NOx,NH3,and VOCs)was compiled to acquire the emission ratios of these sources for the precursors.Then,a regular CMB simulation was executed to obtain the contributions of primary particle sources and secondary components(SO4^2-,NO3^-3,NH4^+,and SOC).Afterwards,the contributions of secondary components were apportioned into primary sources according to the source emission ratios.The final source apportionment results combined the contributions of primary sources by CMB and SEI.This integrated approach was carried out via a case study of three coastal cities(Zhoushan,Taizhou,and Wenzhou;abbreviated WZ,TZ,and ZS)in Zhejiang Province,China.The regular CMB simulation results showed that PM2.5 pollution was mainly affected by secondary components and mobile sources.The SEI results indicated that electricity,industrial production and mobile sources were the largest contributors to the emission of PM2.5 gaseous precursors.The simulation results of the CMB-SEI model showed that PM2.5 pollution in the coastal areas of Zhejiang Province presented complex pollution characteristics dominated by mobile sources,electricity production sources and industrial production sources.Compared to the results of the CMB and SEI models alone,the CMB-SEI model completely apportioned PM2.5 to primary sources and simultaneously made the results more accurate and reliable in accordance with local industrial characteristics. | Nana Cheng Cheng Zhang Deji Jing Wei Li Tianjiao Guo Qiaoli Wang Sujing Li | 2020 | Journal of Environmental Sciences2020，32，6： | 8 |
| 5 | Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin显示文摘Histone methylation is a context-dependent modification that regulates gene expression,and the trimethylation of histone H3 lysine 27(H3K27me3)usually induces gene silencing.Overcoming colorectal cancer(CRC)chemoresistance is currently a huge challenge,but the relationship between H3K27me3 modification and chemoresistance remains largely unclear.Here,we found that H3K27me3 levels positively correlated with the metastasis-free survival of CRC patients and a low H3K27me3 level predicted a poor outcome upon chemotherapeutic drug treatment.Oxaliplatin stimulation significantly induced the expression of H3K27 lysine demethylase 6A/6B(KDM6A/6B),thus decreasing the level of H3K27me3 in CRC cells.Elevation of H3K27me3 level through KDM6A/6B depletion or GSK-J4(a KDM6A/6B inhibitor)treatment significantly enhanced oxaliplatin-induced apoptosis.Conversely,when inhibiting the expression of H3K27me3 by EPZ-6438,an inhibitor of the histone methyltransferase EZH2,the proportion of apoptotic cells remarkably decreased.In addition,the combination of GSK-J4 and oxaliplatin significantly inhibited tumor growth in an oxaliplatin-resistant patient-derived xenograft model.Importantly,we revealed that oxaliplatin treatment dramatically induced NOTCH2 expression,which was caused by downregulation of H3K27me3 level on the NOTCH2 transcription initiation site.Thus,the activated NOTCH signaling promoted the expression of stemness-related genes,which resulted in oxaliplatin resistance.Furthermore,oxaliplatin-induced NOTCH signaling could be interrupted by GSK-J4 treatment.Collectively,our findings suggest that elevating H3K27me3 level can improve drug sensitivity in CRC patients. | Qi Wang Xi Chen Yuhang Jiang Sanhong Liu Hanshao Liu Xiaohua Sun Haohao Zhang Zhi Liu Yu Tao Cuifeng Li Yiming Hu Dandan Liu Deji Ye Yongzhong Liu Mingliang Wang Xiaoren Zhang | 2020 | Journal of Molecular Cell Biology2020，12，2： | 6 |
| 6 | Numerical simulation of the dimensional transformation of atomization in a supersonic aerodynamic atomization dust-removing nozzle based on transonic speed compressible flow显示文摘To simulate the transonic atomization jet process in Laval nozzles,to test the law of droplet atomization and distribution,to find a method of supersonic atomization for dust-removing nozzles,and to improve nozzle efficiency,the finite element method has been used in this study based on the COMSOL computational fluid dynamics module.The study results showed that the process cannot be realized alone under the two-dimensional axisymmetric,three-dimensional and three-dimensional symmetric models,but it can be calculated with the transformation dimension method,which uses the parameter equations generated from the two-dimensional axisymmetric flow field data of the three-dimensional model.The visualization of this complex process,which is difficult to measure and analyze experimentally,was realized in this study.The physical process,macro phenomena and particle distribution of supersonic atomization are analyzed in combination with this simulation.The rationality of the simulation was verified by experiments.A new method for the study of the atomization process and the exploration of its mechanism in a compressible transonic speed flow field based on the Laval nozzle has been provided,and a numerical platform for the study of supersonic atomization dust removal has been established. | Tian Zhang Deji Jing Shaocheng Ge Jiren Wang Xiangxi Meng ShuaiShuai Ren | 2020 | International Journal of Coal Science & Technology2020，7，3： | 6 |
| 7 | Translation and validation of the Tibetan confusion assessment method for the intensive care unit显示文摘Background: At present, there is no available delirium translated assessment method for 3.3 million Tibetans. This study ai provide a method for delirium assessment for Tibetan patients speaking this language by validating a translation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Methods: The study was conducted between July 2018 and November 2018. Patients were screened for delirium by a neurologist using the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV). Patients were subsequently screened by two nurses using Tibetan translations of the CAM-ICU. With DSM-IV criterion as the reference standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess the validity of the CAM-ICU criterion. Interrater reliability was determined by comparing the CAM-ICU ratings of nurse 1 vs. nurse 2 using the k coefficient. Results: Ninety-six patients were assessed independently by two nurses and one neurologist. According to DSM-IV standard, 42 out of 96 (43.8%) patients developed delirium. The sensitivities of Tibetan CAM-ICU were 90.5% for nurse 1 and 92.9% for nurse 2, respectively. Their specificities were 85.2% and 90.7%, respectively. The PPV were 82.6% for nurse 1 and 88.6% for nurse 2. Their NPV were 92.0% and 94.2%, respectively. The Tibetan CAM-ICU was done with good interrater reliability between nurse 1 and nurse 2 (k=0.91, P<0.001). Conclusion: The Tibetan CAM-ICU shows good validity and might be incorporated into clinical practice in Tibetan Intensive Care Units. | Qu-Zhen Danzeng Na Cui Hao Wang Wen-Jun Pan Yun Long Yang-Zong Deji Cheng Ze Zeng Ren | 2019 | Chinese Medical Journal2019，，10： | 4 |
| 8 | 微波 光电子电磁理论显示文摘这是一本有关电磁场及电磁波的教课书。1994年电子工业出版社出版了本书的中文第一版,它的中文第二版于2001年出版。繁体中文版于2004年在中国台北出版。英文第一版于1998年出版,它是对中文第一版的翻译与修订。本书是时隔9年之后的英文第二版。本书的内容是以作者在清华大学所做的有关高级电动力学研究生讲座为基础。多年以来有来自电子工程系和应用物理系的学生上过这门课。他们的专业分别为微波与毫米波理论及技术、物理电子学、光电子与工程物理。正如本书的书名所示, | 张克潜 Dejie Li 胡光华 | 2008 | 国外科技新书评介2008，，5： | 3 |
| 9 | Loss of scleraxis leads to distinct reduction of mineralized intermuscular bone in zebrafish显示文摘Intermuscular bones(IBs)are ossified from tendons and only occur in lower teleosts.Positive association between the regulation of scleraxis gene(scx)and tendon development gave us reasons to speculate that the scx gene may play a potential role in regulating the development of IBs.A phylogenetic analysis conducted for this study revealed potential functional differentiation between two scx orthologues,scxa and scxb.The scxa^(-/-) and scxb^(-/-) zebrafish were generated through CRISPR-Cas9 technology to study the role of scx in the IB and rib development.The results showed a significant reduction of the number of IBs in adult scxa-1^(-/-) zebrafish,with almost 70%reduction(15-25 IBs)compared to the wild type scxa-1^(+/+)zebrafish(76-80 IBs).In the scxa-1^(+/+)adults,IBs were observed in both dorsal and tail segments;however,in scxa-1^(-/-)fish IBs were observed only in the tail segment(none in the dorsal segment).Although scxa-1^(-/-) zebrafish had rib defects,the mutants were viable and fertile as adult fish.The scxb^(-/-) zebrafish had the same number of IBs and same skeletal phenotype as the wild-type fish.This suggests that only scxa has a crucial role in the IB development,and confirms functional differentiation of scx orthologues.To further clarify the molecular mechanism by which scxa affects the IB development,we conducted comparative transcriptome analysis of dorsal tissue samples of scxa-1^(+/+)(with IBs)and scxa-1^(-/-) (without IBs),and further verified the expression of key genes via qPCR.This is the first study to identify a gene that controls the amount of IBs in fish,and it provides a new sight into the effects of scxa on the molecular mechanism of IB development in fish. | Chunhong Nie Shiming Wan Yulong Chen Dejie Zhu Xudong Wang Xiaoru Dong Ze-Xia Gao | 2021 | Aquaculture and Fisheries2021，6，2： | 3 |
| 10 | Soft Open Point Planning in Renewable-dominated Distribution Grids with Building Thermal Storage显示文摘With an increasing integration of intermittent distributed energy resources(DERs),the consequent voltage excursion and thermal overloading issues limit the self-sufficiency of distribution networks(DNs).The concept of soft open point(SOP)has been proposed as a promising solution to improve the hosting capacity of DNs.In this paper,considering the ability of building thermal storage(BTS)to increase the penetration of renewable energy in DNs,we provide an optimal planning framework for SOP and DER.The optimal planning model is aimed at minimizing the investment and operational costs while respecting various constraints,including the self-sufficiency requirement of the DN,SOP,building thermal storage capacity and DER operations,etc.A steady-state SOP model is formulated and linearized to be incorporated into the planning framework.To make full use of the BTS flexibility provided by ubiquitous buildings,a differential equation model for building thermal dynamics is formulated.A hybrid stochastic/robust optimization approach is adopted to depict the uncertainties in renewable energy and market prices.IEEE 33-bus feeder and a realistic DN in the metropolitan area of Caracas are tested to validate the effectiveness of the proposed framework and method.Case studies show that SOP/BTS plays a complementary and coordinated coupling role in the thermo-electric system,thereby effectively improving the hosting capacity and self-sufficiency of DNs. | Tiance Zhang Jianxiao Wang Haiwang Zhong Gengyin Li Ming Zhou Dejie Zhao | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 3 |
| 11 | Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells显示文摘AIM: To explore the roles of microRNA-let7 c(miR-let7 c) and transforming growth factor-β2(TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition(EMT) of retinal pigment epithelial cells. METHODS: Retinal pigment epithelial(ARPE-19) cells were cultured with no serum for 12 h, and then with recombinant human TGF-β2 for different lengths of time. ARPE-19 cells were transfected with 1×106 TU/mL miR-let7 c mimcs(miR-let7 cM), miR-let7 c mimcs negative control(miR-let7cMNC) and miR-let7 c inhibitor(miR-let7 cI) using the transfection reagent. The expression of keratin-18, vimentin, N-cadherin, IKB alpha, p65 were detected by Western blot, quantitative polymerase chain reaction and immunofluorescence. RESULTS: The expression of miR-let7c was dramatically reduced and the nuclear factor-kappa B(NF-κB) signaling pathway was activated after induction by TGF-β2(P<0.05). In turn, overexpressed miR-let7 c significantly inhibited TGF-β2-induced EMT(P<0.05). However, miR-let7 c was unable to inhibit TGF-β2-induced EMT when the NF-κB signaling pathway was inhibited by BAY11-7082(P<0.01). CONCLUSION: The miR-let7 c regulates TGF-β2-induced EMT through the NF-κB signaling pathway in ARPE-19 cells. | Qu-Zhen Deji Feng Yan Wang-Dui Zhaba Ya-Jun Liu Jie Yin Zhen-Ping Huang | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 12 | Numerical analysis of the 2D acoustic field with fuzzy-random parameters显示文摘Regard for the fuzziness and the randomness in some acoustic fields,a method for the numerical analysis of the 2D acoustic field with Fuzzy-Random parameters was proposed based on the equivalent conversion of information entropy.In the proposed method,a fuzzyrandom acoustic field was treated as a pure fuzzy acoustic field or a pure random acoustic field by transforming all the variables into fuzzy variables or random variables.Perturbation finite element methods for analyzing the two-dimensional acoustic fuzzy and random field are deduced.The sound pressure response of a 2D acoustic tube and the 2D acoustic cavity of a car with fuzzy-random parameters were analyzed by the proposed method and the Monte Carlo method,the results show that the proposed method can be well applied to the numerical analysis of the 2D acoustic field with fuzzy-random parameters,and has good prospect of engineering application. | CHEN Ning YU Dejie XIA Baizhan L Hui | 2014 | Chinese Journal of Acoustics2014，33，4： | 2 |
| 13 | Correlation of DNA methylation patterns to the phenotypic features of Tibetan elite alpinists in extreme hypoxia显示文摘High altitude is an extreme environment that imposes hypoxic pressure on physiological processes,and natives living at high altitudes are more adaptive in certain physiological processes.So far,epigenetic modifications under extreme changes in hypoxic pressures are relatively less understood.Here,we recruit 32 Tibetan elite alpinists(TEAs),who have successfully mounted Everest(8848 m)at least five times.Blood samples and physiological phenotypes of TEAs and 32 matched non-alpinist Tibetan volunteers(non-TEAs)are collected for analysis.Genome-wide DNA methylation analysis identifies 23,202 differentially methylated CpGs(P_(adj)<0.05,|β|>0.1)between the two groups.Some differentially methylated CpGs are in hypoxia-related genes such as PPP1R13L,MAP3K7CL,SEPTI-9,and CUL2.In addition,Gene ontology enrichment analysis reveals several inflammation-related pathways.Phenotypic analysis indicates that 12 phenotypes are significantly different between the two groups.In particular,TEAs exhibit higher blood oxygen saturation levels and lower neutrophil count,platelet count,and heart rate.For DNA methylation association analysis,we find that two CpGs(cg16687447,cg06947206)upstream of PTEN were associated with platelet count.In conclusion,extreme hypoxia exposure leads to epigenetic modifications and phenotypic alterations of TEA,providing us clues for exploring the molecular mechanism underlying changes under extreme hypoxia conditions. | Zhuoma Basang Shixuan Zhang La Yang Deji Quzong Yi Li Yanyun Ma Meng Hao WeiLin Pu Xiaoyu Liu Hongjun Xie Meng Liang Jiucun Wang Qiangba Danzeng | 2021 | Journal of Genetics and Genomics2021，48，10： | 2 |
| 14 | Application of EMD method and Hilbert spectrum to the fault diagnosis of roller bearings显示文摘 | Yu Dejie Cheng Junsheng Yang Yu | 2005 | Mechanical Systems and Signal Processing2005，119，： | 1 |
| 15 | Influence of Post-deposition Annealing on the Properties of Transparent Conductive Nanocrystalline ZAO Thin Films Prepared by RF Magnetron Sputtering with Highly Conductive Ceramic Target 显示文摘 | Guojia Fang J Li Dejie Yao Baolun | 2002 | Thin Solid Film2002，418，： | 1 |
| 16 | Numerical treatment of acoustic problems with the smoothed finite element method显示文摘 | YAO Linyun YU Dejie ZANG Xianguo | 2010 | Applied Acoustics2010，71，8： | 1 |
| 17 | Effects of dl-3-n-butylphthalideon expression of VEGF and b FGF in rat brain with permanent for calcerebral ischemia显示文摘 | Li QF Kong SY Deji QZ | 2008 | Sichuan Da Xue Xue Bao Yi Xue Ban2008，39，1： | 1 |
| 18 | A roller bearing fault diagnosis method based on EMD energy entropy and ANN 显示文摘 | Yang Yu Yu Dejie Cheng Jtmsheng | 2006 | Joum of $ouad and Vibrntioa2006，294，12： | 1 |
| 19 | A fault diagnosis approach for roller bearings based on EMD method and AR model显示文摘 | Cheng Junsheng Yu Dejie Yang Yu | | 0，，2： | 1 |
| 20 | The application of energy operator demodulation approach based on EMD in machinery fault diagnosis显示文摘 | Cheng Junsheng Yu Dejie Yang Yu | 2005 | Mechanical Systems and Signal Processing2005，，2： | 1 |
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