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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | 抑制性控制在幼儿执行功能与心理理论中的作用显示文摘将执行功能任务和心理理论任务中的共同成分--抑制性控制区分为3个不同的难度水平,从而构成心理理论任务(错误信念)的3个变式A1、A2、A3和执行功能任务(白天/黑夜)的3个变式B1、B2、B3.实验1以48名4岁幼儿为被试,探讨对两类任务中各自的3个变式所包含的抑制性控制的难度区分的适当性,结果表明幼儿在两类任务中各自的3个变式上的正确率差异显著,说明其抑制性控制的确表现出了高、中、低3个不同的难度水平;实验2根据实验1所设计的两类任务,以144名3~6岁幼儿为被试,探讨了不同抑制性控制的难度水平在幼儿执行功能和心理理论的相关中的作用,结果表明抑制性控制的难度水平是影响幼儿执行功能与心理理论的相关的一个重要因素. | 魏勇刚 吴睿明 李红 冯廷勇 Philip David Zelazo | 2005 | 心理学报2005，37，5： | 37 |
| 3 | 不同维度的执行功能与早期心理理论的关系显示文摘采用意外地点任务、意外内容任务和三种不同类型的执行功能任务来探究执行功能与心理理论之间的关系。共60名被试,3岁和4岁被试各30名,男女各半。区分自己心理状态和他人心理状态能力与执行功能的关系主要体现在混合成分执行功能与这一能力的密切联系上;在错误信念发展的早期,执行功能与错误信念理解能力的关系主要集中在“混合成分的执行功能与对自己错误信念理解能力,工作记忆的执行功能与对他人错误信念理解能力”这两对联系上。 | 张婷 吴睿明 李红 Philip David Zelazo 张莉 廖渝 李小晶 | 2006 | 心理学报2006，38，1： | 38 |
| 4 | GRADE指南:Ⅱ.构建问题、确定重要结果显示文摘GRADE要求明确说明相关的背景、人群、干预措施和对照,同时要求不论研究结果能否形成证据,均需详述所有重要结果。对某一特定管理问题,人群、干预措施及结果应在不同研究间足够类似,才能认为得到相似的效应量合乎情理。指南制定者在收集证据前应先详细说明各结局的相对重要性,同样地,证据总结完成时也需要详细说明这一点。考虑到替代结局的重要性,对采用替代指标描述且对患者很重要的结局,作者应评估其重要性,并进而降低这种间接结果的证据质量等级。 | Gordon H.Guyatt Andrew D.Oxman Regina Kunz David Atkins Jan Brozek Gunn Vist Philip Alderson Paul Glasziou Yngve Falck-Ytter Holger J.Schünemann GRADE工作组 李幼平 杨晓妍 陈群飞 | 2011 | 中国循证医学杂志2011，11，4： | 40 |
| 5 | 地下水铀污染的原位微生物还原与固定:在美国能源部田纳西橡树岭放射物污染现场的试验显示文摘总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后通过加入溶解氧和硝酸盐来试验微生物还原后的地下水层中还原固定态铀的稳定性.通过预处理和长期间隔注入乙醇溶液,地下水中铀浓度从40~60mg·L-1降至0.03mg·L-1以下,达到了美国环保署饮用水的标准.还原的四价铀主要以U(Ⅳ)-Fe复合物的形态存在.结果表明,固定化后的四价铀只有在厌氧条件下才是稳定的,溶解氧和硝酸盐侵入地下水层后会使固定化的四价铀重新氧化为溶解态的六价铀.在试验过程中,采用多种分子生物学方法检测了微生物种群的变化和与铀氧化还原反应有关的功能微生物.本研究表明,在维持试验系统无氧和无硝酸盐的条件下,通过添加乙醇为电子供体可有效地促进地下水中土著功能微生物的活性,从而实现铀的原位还原固定与稳定. | 吴唯民 Jack Carley David Watson 顾宝华 Scott Brooks Shelly D.Kelly Kenneth Kemner Joy D.van Nostrand 吴力游 许玫英 周集中 罗剑 Erick Cardenas 黄家琪 Matthew W.Fields Terence L.Marsh James M.Tiedje Stefan J.Green Joel E.Kostka Peter K.Kitanidis Philip M.Jardme CraigS.Criddle | 2011 | 环境科学学报2011，31，3： | 28 |
| 6 | 意外地点任务中不同测试问题及意图理解与执行功能的关系显示文摘旨在讨论意外地点任务中“知否问题”与“预测问题”可能存在的差异及两者与执行功能任务的关系,并初步探讨意图理解与执行功能问的关系。用意外地点任务、膝跳反射任务和两个执行功能的任务(DCCS和手部游戏)对59名3~5岁的儿童施测。结果显示:(1)儿童在意外地点任务的“知否问题”上的表现显著好于“预测问题”,儿童对“知否问题”和“预测问题”的回答可能反映了心理理论发展的不同阶段。(2)膝跳反射任务,DCCS任务与“知否问题”三者问有显著的相关,且其高相关在排除年龄及语言能力的影响后仍保持显著。“双表征区分结构”可能是三者间共同的成分。 | 廖渝 吴睿明 Philip David Zelazo 李红 张婷 张莉 高山 李小晶 | 2006 | 心理学报2006，38，2： | 16 |
| 7 | 颅内血管神经介入治疗的适应证美国心脏协会心血管放射学和介入委员会、卒中委员会、心血管外科和麻醉委员会、外周血管病跨学科委员会以及护理质量和转归研究跨学科委员会的联合学术声明显示文摘颅内血管内介入是一种使用微侵袭血管内技术治疗脑血管病的方法。该专业领域在过去10年里取得了巨大进展,而且随着该学科得到越来越多的临床认可,这种进步的速度还在加快。 | Philip M. Meyers H. Christian Schumacher Randall T. Higashida Stanley L. Barnwell Mark A. Creager Rishi Gupta Cameron G. McDougall Dilip K. Pandey David Sacks Lawrence R. Wechsler 乔梵(译) 刘建民(译) 洪波(译) | 2009 | 国际脑血管病杂志2009，17，10： | 16 |
| 8 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 9 | Grass height and transmission ecology of Echinococcus multilocularis in Tibetan communities, China显示文摘背景牙槽的包虫病是在西方的中国的公共健康意义的主要动物病。过度放牧最近为牙槽的包虫病的传播作为一个潜在的风险因素被假定。研究被设计进一步由调查过度放牧怎么影响了中间的主人的洞穴密度测试过度放牧的假设小哺乳动物并且小哺乳动物的洞穴密度怎么与狗包虫 multilocularis infection.Methods 被联系学习地点被发现了牙槽的包虫病是流行的区域的以前的研究选择。数据包括草高度,挖中间的主人的密度烘便的样品以及全球放系统(GPS ) 放的小哺乳动物,狗和狐狸,在 Shiqu 县从领域调查被收集,四川省,中国。烘便的样品用 copro-PCR 被分析。在烘便的样品的蠕虫,牙齿,骨头和头发视觉上被检验。包括 chi 平方和概括线性模型的单个因素和 multifactor 分析工具被把草高度用作在同质的牧场擦伤压力的一个代理用于这些 data.Results ,在导致的牧场发现那棵更高的草的这研究降低小哺乳动物的洞穴密度 X^2=A.67O , P=0.031 , coefficient=-1.570 )。在狗的包虫 multilocularis 蠕虫负担是显著地统计上与中介的最大的密度有关招待 Ochotona spp。(X^2=5.250, P=0.022, coefficient=0.028 ) 。在拥有的狗的流行断然被相关到在 200 米半径以内看见的迷路的狗的数字(Wald X^2=8.375, P=0.004,机会 ratio=1.198 ) 。结论我们的调查结果支持过度放牧支持的假设牙槽的包虫病的传播并且在牙槽的包虫病的传播证实迷路的狗的角色。 | WANG Qian Francis Raoul Christine Budke Philip S. Craig XIAO Yong-fu, Dominique A. Vuitton,Maiza Campos-Ponce, QIU Dong-chuan, David Pleydell and Patrick Giraudoux XIAO Yong-fu Dominique A. Vuitton Maiza Campos-Ponce QIU Dong-chuan David Pleydell Patrick Giraudoux | 2010 | Chinese Medical Journal2010，，1： | 12 |
| 10 | CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment显示文摘 | Andy Trotti A.Dimitrios Colevas Ann Setser Valerie Rusch David Jaques Volker Budach Corey Langer Barbara Murphy Richard Cumberlin C.Norman Coleman Philip Rubin | 2003 | Seminars in Radiation Oncology2003，，3： | 8 |
| 11 | 参与式渭南地震情景构建:中国地震风险对策的行动研究示范显示文摘中国政府层面自上而下的防震减灾管理卓有成效;但是,对于提升全社会的整体防震减灾能力而言,尚需推动基于此而又有民众与基层自下而上广泛参与的全社会治理模式。为发展这种模式积累经验,渭南市地震情景构建示范项目借助参与式行动研究范式,特别关注了中国防震减灾工作当前存在的以下2点广泛不足:一是社会民众与基层的自下而上办法薄弱,且与政府层面自上而下对策之间的相互衔接与促进不足;二是科学研究向实际减灾对策的转化不足,特别是针对自下而上办法的科学研究与应用转化不足。取得的主要进展有:1)基于广泛参与理念,通过'研究者'和'减灾实践者'、'相关者'、'当事人'2方面人员间的密切合作,共同诊断评估了渭南面临的主要地震灾害风险及隐患、共同提炼了针对性的减灾对策改进建议等,从而使情景构建所得的结果或认识更加可靠、所提对策建议更加符合当地实际需要;借助行动研究过程平台,尝试了风险评估、风险沟通和风险对策改进3大环节的无缝衔接与同步互动,促进了科学研究与实际应用的直接对接与就地转化。2)基于多尺度、多层面视角和同时为'政府'或'部门'与'基层'或'民众'两大类用户服务。在关注改进自上而下对策的同时,针对薄弱的自下而上办法,特别是就这两大对策途径间最广泛与最可持续的接口——宣传教育和家庭、学校、社区减灾,开展了大规模的专项调查分析,梳理了系列化的现今本底与改进方向。3)聚焦改善减灾宣教和促进风险沟通,编创了由'故事'引导的2版内容与形式均有显著差别的地震情景叙事读本:政府版和公众版,以期借助'故事'和艺术呈现'故事'带动人们更好地理解与应用情景构建结果和认识,借助'故事'演绎社会性灾害脆弱成分——'留守儿童家庭与贫困'之于灾害的强化与叠加效应,促进人们对地震灾害风险更加全面与深入的认识;在理性刻板科学中融入感性与人文艺术情怀,以引导共识与共鸣、改善减灾态度、培养减灾价值观,进而激发减灾行动和减灾参与意愿,特别是激励人们就相关问题进行长期思考和持续行动改善。以上3方面进展,从总体上实现了对中国防震减灾工作存在的前述2点广泛不足的有益研讨与部分弥补推动尝试。参与式渭南地震情景构建行动研究示范,对国内相关工作具有抛砖引玉的作用,也为国际同类工作积累了中国经验。 | 苏桂武 Janise Rodgers 田青 齐文华 Philip England Timothy Sim John Young 王东明 李志强 冯希杰 孙磊 陈鲲 Emily So Barry Parsons 赵金礼 石建梁 袁志祥 Yue Cao 周旗 魏本勇 David Milledge Alexander Densmore | 2020 | 地震地质2020，42，6： | 6 |
| 12 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 13 | The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor symptoms.Etiology is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental factors.Main body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell death.However,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause disease.Discovery of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD risk.Nevertheless,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be excluded.The lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of PD.Rare mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD risk.Heritability of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most patients.Conclusion:PD is a multifactorial disorder involving interplay of aging,genetics and environmental factors.This has implications on the development of appropriate animal models of PD which take all these factors into account.Common converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are associated with the accumulation and spread of misfoldedα-synuclein and neurodegeneration.Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course. | Shirley Yin-Yu Pang Philip Wing-Lok Ho Hui-Fang Liu Chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 14 | Choice of conodont Idiognathodus simulator (sensu stricto) as the event marker for the base of the global Gzhelian Stage (Upper Pennsylvanian Series, Carboniferous System)显示文摘 | Philip H. Heckel Aleksandr S. Alekseev James E. Barrick Darwin R. Boardman Natalya V. Goreva Tatiana N. Isakova Tamara I. Nemyrovska Katsumi Ueno Elisa Villa David M. Work | 2008 | Episodes2008，31，3： | 5 |
| 15 | Evidence Suggesting That a Chronic Disease Self-Management Program Can Improve Health Status While Reducing Hospitalization: A Randomized Trial显示文摘 | Kate R. Lorig David S. Sobel Anita L. Stewart Byron William Brown Albert Bandura Philip Ritter Virginia M. Gonzalez Diana D. Laurent Halsted R. Holman | 1999 | Medical Care1999，，1： | 4 |
| 16 | Seasonal variation for the antidiabetic activity of Loranthus micranthus methanol extract显示文摘Objective:To determine the season in which the Eastern Nigeria mistletoe,Loranthus micranthus,parasitic on Persea americana possesses optimum antidiabetic activity and to determine the seasonal variation in the constituents.Methods:The antidiabetic activities of the aqueous methanol extracts of the leaves of Eastern Nigeria mistletoe,Loranthus micranthus, harvested in two seasons of the year,the onset of rainy season(April) and the peak of rainy season(July) were compared.The tests were carried out on six(6) groups(A-F) of alloxaninduced diabetic rats.Groups A and B received 200 mg/kg and 400 mg/kg of the April sample extracts respectively while groups C and D received same doses of the July sample extracts. Group E and F which were the positive and negative controls received 10 mg/kg of glibenclamide and 2 ml/kg of 3%tween 20 respectively.The blood glucose levels of the animals were monitored hourly with a glucometer for six hours.The phytochemical analysis of the plant extracts were also carried out by standard procedures.Results:The results showed that group A and B exhibited significant(P<0.05) percentage reduction in the fasting blood sugar(FBS) level of the animals(38.9%and 39.2%respectively) with maximum reduction observed at the 5th and 6th hour respectively compared to glibenclamide(71.3%).Group C showed no significant (P>0.05) FBS reduction(15.9%) while group D exhibited highly significant(P<0.01) reduction (47.5%) with the maximum reduction occurring after 6 hours.The phytochemical analysis of the crude methanol extracts revealed the presence of carbohydrates,glycosides,saponins, tannins,flavonoids,steroids,terpenoids,acidic compounds,resins and oils.These were present in different proportions in both seasons.Conclusions:This study shows that there is a seasonal, dose-dependent variation in the chemical composition viz-a-viz the antidiabetic activity of the plant under study.This activity is highest at the peak of the rainy season. | Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Philip Felix Uzor Ernest Kenechukwu David Damian Chiedozie Obiorah | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 4 |
| 17 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 18 | Antidiabetic principles of Loranthus micranthus Linn.parasitic on Persea americana显示文摘Objective:To explore antidiabetic principles of the Eastern Nigeria mistletoe,Loranlhus micranthus Linn,parasitic on Persea Americana.Methods:The weakly acidic fraction of the aqueous methanol extract of the leaves of Loranlhus micranthus(Linn.) was isolated and tested for its antidiabetic activities.The isolation of the weakly acidic fraction was carried out following established physico-chemical based procedures.Furthermore,alloxan-induced diabetic rats were treated intraperitoneally(ip) with 250 mg/kg and 400 mg/kg of the weakly acidic fraction, glibenclamide 10 mg/kg(positive control) and 2 mg/kg of 3%v/v tween 20(negative control).The sugar levels of the treated and untreated animals were determined by withdrawing the blood at regular intervals and testing them with an automated glucometer.The phytochemical analysis of the acidic fraction was carried out using standard procedures.Chromatographic techniques were employed in the subsequent isolation and purification of the constituents of the weakly acidic fraction.Results:It was shown that the maximum effect of the weakly acidic fraction was obtained at 24 hours after administration and was found to be statistically comparable with that of the positive control.The phytochemical analysis revealed the presence of steroids,terpenoids, alkaloids,flavonoids,glycosides,carbohydrates,saponins,and acidic compounds in the crude extract and carbohydrates,flavonoids.terpenoids and oil in the weakly acidic fraction.Further purification of the weakly acidic fraction of the methanol extract using thin layer chromatography shows that toluene:methanol:diethyl amine(3:1:1) and chloroform:methanol:diethyl amine (9:1:1) are the best solvent system for the isolation of the various components of the weakly acidic fraction of the crude methanol extract of Loranlhus micranthus.Conclusions:The present study has led to the conclusion that the weakly acidic fraction of the plant under study has the potent antidiabetic activity and that the various components can be isolated using basic chromatographic techniques. | Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Sylvester Chukwuemeka Nworu Charles Okechukwu Esimone Philip Felix Uzor Ernest kenechukwu David John Uchechukwu Uzoma | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 4 |
| 19 | Lipids, Apolipoproteins, and Their Ratios in Relation to Cardiovascular Events With Statin Treatment显示文摘 | John J.P. Kastelein Wim A. van der Steeg Ingar Holme Michael Gaffney Nilo B. Cater Philip Barter Prakash Deedwania Anders G. Olsson S Matthijs Boekholdt David A. Demicco Michael Szarek John C. LaRosa Terje R. Pedersen Scott M. Grundy | 2008 | Circulation2008，，23： | 3 |
| 20 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
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