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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Oral glutamine in the prevention of fluomuracil induced intestinal toxicity: a double blind, placebo controlled, randomized trial显示文摘 | Daniele B Perrone F Gallo C | 2001 | Gut2001，48，1： | 1 |
| 5 | Vocal response to pain in piglets显示文摘 | Daniel M W Leah A B David F | 1998 | Applied Animal Behaviour Science1998，56，2： | 1 |
| 6 | Mechanism of AP - 1 - mediated gene expression by select organochlorines through the p38 MAPK pathway显示文摘 | Daniel E F Yan T B Beckman S | 2004 | Carcinogencsis2004，25，2： | 1 |
| 7 | Effect of relative impeller-to-volute position on hydraulic efficiency and static radial force distribution in a circular volute cen- trifugal pump 显示文摘 | Daniel O B Lutz K Ronald D F | 2000 | Transactions of the ASME2000，122，3： | 1 |
| 8 | Toxicity studies of 1,3- dichlorobenzene in Sprague-Dawley rats显示文摘 | McCauley P T Robinson M Daniel F B | 1995 | Drug and Chemical Toxicology1995，18，23： | 1 |
| 9 | Enhancing Peer-to-Peer Content Discovery Techniques over Mobile Ad hoe Networks 显示文摘 | Diego N da Hora Daniel F Macedo Leonardo B Oliveira | 2009 | Computer Communications (S0140-3664)2009，32，1314： | 1 |
| 10 | Modelling global risk factors affecting construction cost performance显示文摘 | DANIEL B PRICE A D F | 2003 | Intern J Proj Manag2003，21，4： | 1 |
| 11 | An extrusion system for the processing of microcellular polymer sheets : Shaping and cell growth control 显示文摘 | Daniel F Baldwin C B Park Nam P Suh | 1996 | Polymer Engineering and Science1996，36，10： | 1 |
| 12 | Thepopliteal ryst显示文摘 | Daniel F Jean F Stefano B | 2006 | Knee Surg Sports TraumatoiArthrosn2006，14，7： | 1 |
| 13 | Simulation of mixed models in augmented block design 显示文摘 | Aladir H S Eduardo B Daniel F F | 2002 | Scientia Agricola2002，59，3： | 1 |
| 14 | Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde and dichloroacetic acid in the male B6C3F1 mouse 显示文摘 | Daniel F B | 1992 | Fundamental and Applied Toxicology1992，19，2： | 1 |
| 15 | Linear, Random Representations of Chaos显示文摘 | Daniel F D Douglas B W | 2007 | IEEE Transactions on Signal Processing2007，55，4： | 1 |
| 16 | The effects of logistics capabilities and strategy on firm performance 显示文摘 | DANIEL F L SCOTF B K JOHN O | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 17 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 18 | Carrageenans: biological properties, chemical modifications and structural analysis: review显示文摘 | VANESSA L C DANIEL F K DfLSON B S | 2009 | Carbohydrate Polymers2009，77，： | 1 |
| 19 | Identification of Monosaccharides by High-performance Liquid Chromatography Using Methanolysis and a Light-scattering Detector显示文摘 | Myriam T Arlette E B Danielle B F | 1990 | J Chromatogr1990，514，1： | 1 |
| 20 | Powerful CEOs and Their Impact on Corporate Performance显示文摘 | Adams R B Heitor A Daniel F | 2005 | The Review of Financial Studies2005，18，4： | 1 |
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