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| 1 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 2 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 3 | Hydrothermal processing of lignccellulosic materials显示文摘 | GARROTE G DOM(I)NGUEZ H PARAJ(O) J | 1999 | Holzals Rohund Werkstoff1999，57，3： | 1 |
| 4 | Orbitalcavernoushemangioma : findings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，： | 1 |
| 5 | Orbital cavernous hemangioma: find- ings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，4： | 1 |
| 6 | Functionality of oilseed protein products:a review显示文摘 | MOURE A SINEIRO J DOMNGUEZ H | 2006 | Food Research International2006，39，9： | 1 |
| 7 | Hydrothermal processing of lignocellulosic materials显示文摘 | Garrote G Dom?? nguez H Parajo JC | 1999 | Holz als Roh- und Werk- stoff1999，57，3： | 1 |
| 8 | Bioconversion of posthy-drolysed autohydrolysis liquors:an alternative for xylitol production from corncobs显示文摘 | RIVAS B DOMNGUEZ J M DOMNGUEZ H | 2002 | Enzyme and Microb Technobial Technology2002，31，4： | 1 |
| 9 | Prostate cancinoma:Staging by clinical assessment,CT,and MRI显示文摘 | Doms GC Jeffrey RB | 1987 | Radiology1987，162，： | 1 |
| 10 | Focused crawling: a new approach to topic-specific Web resource discovery 显示文摘 | Chakrabarti S M van den Berg H Dom B | 1999 | Computer Networks1999，31，1116： | 1 |
| 11 | Enzymaticsaccharification of alkali-treated sunflower hulls显示文摘 | Soto M L Domínguez H Núńez M J | 1994 | Biore-source Technology1994，49，： | 1 |
| 12 | Statistical analysis of wind power forecast error 显示文摘 | Bludszuweit H Domí nguez-Navarro J A Llombart A | 2008 | IEEE transactions on Power Systems2008，23，3： | 1 |
| 13 | Dosimetry-guided radioactive iodine treatment in patients with metstatic differtiatiated thyroid cancer: largest safe dose using a riskadapted approach显示文摘 | Dom R Kopp J Vogt H | 2003 | J NuclMed2003，44，3： | 1 |
| 14 | Xylooligosaccharides:properties and production technologies显示文摘 | Alonso J L Domínguez H Garrote G | 2003 | Electronic Journal of Evironmental Agricultural and Food Chemistry2003，2，1： | 1 |
| 15 | Solvent extraction of hemicellulosic wood hydrolysates:a procedure useful for obtaining both detoxified fermentation media and polyphenols with antioxidant activity显示文摘 | Cruz JM Domínguez JM Domínguez H | 1999 | Food Chemistry1999，67，2： | 1 |
| 16 | Meta - analysis of satisfaction with medical care description of domain and analysis of overall satisfaction levels 显示文摘 | H all JA Dom an MC | 1998 | SocScMed1998，27，6： | 1 |
| 17 | Simple PN Code Sequence Estimation and Synch Ronization Technique Using the Constrained Hebbian Rule 显示文摘 | DOM RNIQUE F REED J H | 1997 | Electronics Letters1997，33，1： | 1 |
| 18 | Antioxidant and antimicrobial effects of extracts from hydrolysates of lignocellulosic materials显示文摘 | Cruz JM Domínguez JM Domínguez H | 2001 | Journal of Agricultural and Food Chemistry2001，49，5： | 1 |
| 19 | Host cell-catalyzed Spalmitoylation mediates Golgi targeting of the legionella ubiquitin ligase Gob X显示文摘 | LIN Y H DOMS A G CHENG E | 2015 | J Biol Chem2015，290，25： | 1 |
| 20 | Production of antioxidants by non-isothermal autohydrolysis of lignocellulosic wastes显示文摘 | Conde E Moure A Domínguez H | 2011 | LWT-Food Science and Technology2011，44，2： | 1 |
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