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| 1 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 2 | Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps显示文摘AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P < 0.001). However,there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC. | Ali Karaman Dogan Nas■r Binici Mehmet E■ref Kabalar Züleyha ■al■ku■u | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Laparoscopic surgery in veterinary medicine显示文摘 | Yanmaz L E Okumus Z Dogan E | 2007 | Vet Res2007，1，1： | 1 |
| 4 | Determining attribute weights in a CBR model for early cost prediction of structural systems 显示文摘 | Dogan S Z Arditi D Giinaydyn H M | 2006 | Journal of Construction Engineering and Management ASCE2006，，10： | 1 |
| 5 | Identification and mapping of submerged plants in a shallow lake using quick bird satellite data显示文摘 | Dogan O K Akyu rek Z Bek lioglu M | 2008 | Environmental Management2008，，： | 1 |
| 6 | Effect of dexmedeto-midine on bleeding during tympanoplastyor septorhinoplasty显示文摘 | Durmus M But A K Dogan Z Yucel A | | 0，，05： | 1 |
| 7 | Small bowel volvulus secondary to post appendectomy adhesion band显示文摘 | Karabulut Z Dogan P | 2013 | Turk J Gas troenterol2013，24，3： | 1 |
| 8 | Factors affecting the shape of lactation curves of Holstein cows from the Balikesir province of Turkey显示文摘 | TEKERLI M AKINCI Z DOGAN I | 2000 | J Dairy Sci2000，83，： | 1 |
| 9 | E-cadherin expression in intestinal epithelium显示文摘 | DOGAN A WANG Z D SPENCER J | 1995 | J Clin Pathol1995，48，： | 1 |
| 10 | The effect of VEGF on survival of random flap in the rat:examination of various routes of administration显示文摘 | Kryger Z Zhang F Dogan T | 2000 | Br J Plast Surg2000，53，： | 1 |
| 11 | Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy显示文摘 | Atilgan S Ekmekci Z Dogan A L | 2006 | Chem Commun2006，42，： | 1 |
| 12 | The effects of VEGF on survivalof a random flap in the rat:examination of various routes of administration显示文摘 | Kryger Z Zhang F Dogan T | 2000 | BrJ Plast Surg2000，53，： | 1 |
| 13 | Forms of adjustment: sociocultural impacts of tourism显示文摘 | DOGAN H Z | 1989 | Annals of Tourism Research1989，16，2： | 1 |
| 14 | Identification and mapping of submerged plants in a shallow lake using quickbird satellite data显示文摘 | Dogan O K Akyurek Z Beklioglu M | 2009 | Environmental Magagement2009，90，7： | 1 |
| 15 | Effects of VEGF administration following ischemia on survival of the gracilis muscle flap in the rat 显示文摘 | Kryger Z Dogan T Zhang F | 1999 | Ann Plast Surg1999，43，： | 1 |
| 16 | Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy显示文摘 | Atilgan S Ekmekci Z Dogan A L | | 0，，： | 1 |
| 17 | The effect of vegf on survival of a random flap in the rat:examination of various routes of administration显示文摘 | Kryger Z Zhang F Dogan T | 2000 | Briti Plast Surg2000，6，： | 1 |
| 18 | Retrospective evalua- tion of the cases prediagnosed as viral encephalitis in Trace University Hospital between the period of 2000--2005 显示文摘 | Yulugkural Z Dogan Celik A Celik Y | 2008 | Mikrobiyol Bul2008，42，2： | 1 |
| 19 | The in vitro effects of isoflurane,sevoflurane, and propofol on platelet aggregation 显示文摘 | Dogan IV Ovali E Eti Z | 1999 | Anesth Analg1999，88，2： | 1 |
| 20 | In vivo and in vitro effects of a HIF-1alpha inhibitor,RX-0047显示文摘 | Dikmen Z G Gellert G C Dogan P | 2008 | J Cell Biochem2008，104，3： | 1 |
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