维普期刊资源整合服务平台（V6.5）

178篇 您的检索式：作者名="DIETEL"

选中清除导出查看参考文献查看引证文献引用追踪共9页首页上一页第1页下一页末页 /9 跳转

	题名	作者	年代	出处	被引量
1	Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity.	Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert	2005	World Journal of Gastroenterology2005，11，36：	16
2	Mucosal flora in inflammatory bowel disease显示文摘	Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs	2002	Gastroenterology2002，，1：	2
3	Histopathological regression grading matches excellently with local and regional spread after neoadjuvant therapy of rectal cancer显示文摘	Sefer Elezkurtaj Lutz Moser Jan Budczies Alice Josephine Müller Hendrik Bl?ker Heinz Johannes Buhr Manfred Dietel Martin Kruschewski	2013	Pathology - Research and Practice2013，，7：	2
4	Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells显示文摘	Lage H Dietel M	2002	J Cancer Res Clin Oncol2002，128，7：	1
5	Laparoscopic surgery in urology:Taining and education显示文摘	Rabenalt R Minh D Dietel A		0，，09：	1
6	Decreased numbers of reg- ulatory T cells are associated with human atherosclerotic le- sion vulnerability and inversely correlate with infiltrated ma- ture dendritic cells显示文摘	Dietel B Cicha I Voskens CJ	2013	Atherosclerosis2013，230，1：	1
7	HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘	Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe	2010	Virchows Archiv2010，，3：	1
8	Predictive molecular pathology and its role in targeted cancer therapy:a review focussing on clinical relevance显示文摘	Dietel M Johrens K Laffert M		0，，04：	1
9	MCS-18, a natural product isolated from Helleborus purpurascens, inhibits matu- ration of dendritic cells in ApoE-deficient mice and prevents early atherosclerosis progression 显示文摘	Dietel B Mueneh R Kuehn C	2014	Atherosclerosis2014，235，2：	1
10	Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells显示文摘	Lage H Dietel M	2002	J Cancer Res Clin Oncol2002，128，7：	1
11	Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5显示文摘	Lage H Dietel M	1997	Gene1997，188，2：	1
12	Modulation of DNA topoisomerase Ⅰ activity and expression in melanoma cell with acquired drug resistance显示文摘	Lage H Helmbach H Dietel M	2000	Br J Cancer2000，82，2：	1
13	Expression of thyroid transcription factor - 1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of varous primary sites 显示文摘	Kanfmann O Dietel M	2000	Histopathology2000，36，5：	1
14	GOLPH2 expression in renal cell cancer显示文摘	Fritzsche FR Riener MO Dietel M	2008	BMC Urol2008，8，：	1
15	Immunohistochemical differentiation of metastases of renal carcinoma versus other carcinoma with anti-gamma GT monocleonal antibody 138H11 显示文摘	Kaufmann O Dietel M Scherberich JE	1997	Histopathology1997，31，：	1
16	Thyroid transcription factor-1 is the superior immunohistochemical maker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B 显示文摘	Kaufmann O Dietel M	2000	Histopathology2000，36，1：	1
17	显示文摘	Bruma M Mercer F W Schulz B Dietel R Fitch J Cassidy P	1994	High Perf Polym1994，6，：	1
18	HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘	Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe	2010	Virchows Archiv2010，，3：	1
19	Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257显示文摘	Dietel M Arps H Lage H	1990	Cancer Res1990，50，18：	1
20	Selection of a high activity c-erbB-2 ribozyme using a fusion gene of c-erbB-2 and the enhanced green fluorescent protein显示文摘	Zimmer C Dietel M	1998	Cancer Gene Ther1998，5，1：	1

返回顶部每页显示：

共9页首页上一页第1页下一页末页 /9 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示