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| 1 | Microstructure and mechanical properties of Ti-6Al-4V-5% hydroxyapatite composite fabricated using electron beam powder bed fusion显示文摘A novel, Ti-6 Al-4 V(Ti64)/Hydroxyapatite(HA at 5% by weight concentration) metal/ceramic composite has been fabricated using electron beam powder bed fusion(EPBF) additive manufacturing(AM): specifically, the commercial electron beam melting(EBM?) process. In addition to solid Ti64 and Ti64/5% HA samples, four different unit cell(model) open-cellular mesh structures for the Ti64/5% HA composite were fabricated having densities ranging from 0.68 to 1.12 g/cm^3, and corresponding Young's moduli ranging from 2.9 to 8.0 GPa, and compressive strengths ranging from ~3 to 11 MPa. The solid Ti64/5%HA composite exhibited an optimal tensile strength of 123 MPa, and elongation of 5.5% in contrast to a maximum compressive strength of 875 MPa. Both the solid composite and mesh samples deformed primarily by brittle deformation, with the mesh samples exhibiting erratic, brittle crushing. Solid, EPBF-fabricated Ti64 samples had a Vickers microindentation hardness of 4.1 GPa while the Ti64/5%HA solid composite exhibited a Vickers microindentation hardness of 6.8 GPa. The lowest density Ti64/5%HA composite mesh strut sections had a Vickers microindentation hardness of 7.1 GPa. Optical metallography(OM) and scanning electron microscopy(SEM) analysis showed the HA dispersoids to be highly segregated along domain or grain boundaries, but homogeneously distributed along alpha(hcp) platelet boundaries within these domains in the Ti64 matrix for both the solid and mesh composites. The alpha platelet width varied from ~5 μm in the EPBF-fabricated Ti64 to ~1.1 m for the Ti64/5%HA mesh strut. The precursor HA powder diameter averaged 5 μm, in contrast to the dispersed HA particle diameters in the Ti64/5%HA composite which averaged 0.5 m. This work highlights the use of EPBF AM as a novel process for fabrication of a true composite structure, consisting of a Ti64 matrix and interspersed and exposed HA domains, which to the authors' knowledge has not been reported before. The results also illustrate the prospects not only for fabricating specialized, novel composite bone replacement scaffolds and implants, through the combination of Ti64 and HA, but also prospects for producing a variety of related metal/ceramic composites using EPBF AM. | César A.Terrazas Lawrence E.Murr Diego Bermudez Edel Arrieta David A.Roberson Ryan B.Wicker | 2019 | Journal of Materials Science & Technology2019，35，2： | 4 |
| 2 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 3 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 4 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 5 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 6 | Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine 显示文摘 | BURASHNIKOV A DI DIEGO J M ZYGMUNT A C | 2007 | Circulation2007，116，13： | 1 |
| 7 | Functional modulation of the transient outward current Ito by KCNE β-subunits and regional distribution in human non-failing and failing hearts显示文摘 | Susanne R Diego C Eva MG | | 0，，： | 1 |
| 8 | Solid waste management of a chemical-looping combustion plant using Cu-based oxygen carriers显示文摘 | Labiano F G Gayan P Adanez de Diego L Forero C R | 2007 | Environment Science Technology2007，41，6： | 1 |
| 9 | Structural properties of XPath fragment显示文摘 | Michael B Diego C Wenfei F | 2003 | ICDE heidelberg springer2003，12，4： | 1 |
| 10 | Ischemic ventriculararrhythmias: experimental models and their clinicalrelevance显示文摘 | Di Diego JM Antzelevitch C | 2011 | Heart Rhythm2011，8，12： | 1 |
| 11 | Physical ageing studies in polyetherimide ULTEM 1000 显示文摘 | Belana J Canadas J C Diego J A | 1998 | Polym Int1998，46，1： | 1 |
| 12 | The relationship of in-ternet use to depression and social isolation among adoles-cents显示文摘 | Sanders C Field T Diego M | 2000 | Adolescence2000，，： | 1 |
| 13 | A neuro-immune mode for discriminating and visualizing anomalies显示文摘 | Fabio A.G Juan C G Diego A R | | 0，，03： | 1 |
| 14 | Anthocyanin extraction from Jabuticaba (Myrciariacauliflora)skins by different techniques:economic evaluation显示文摘 | Priscilla C Veggi Diego T Santos M Angela | | 0，，01： | 1 |
| 15 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 16 | Mapping wound-response genes involved in post-harvest physiological deterio-ration(PPD)of cassava(Manihot esculenta Crantz)显示文摘 | DIEGO F C KIM R EMMANUEL O | 2002 | Euphytica2002，128，： | 1 |
| 17 | Influence of operating parameters on NOx and N2O axial profiles in a circulating fluidized bed combustor显示文摘 | Diego L F Londono C A Wang X S | 1996 | Fuel1996，，8： | 1 |
| 18 | Cisapride-inducedtransmural dispersion of repolarization and torsade de pointes in thecanine left ventricular wedge preparation during epicardial stimula-tion显示文摘 | Di Diego JM Belardinelli L Antzelevitch C | 2003 | Circulation2003，108，8： | 1 |
| 19 | Influence of Operating Parameters on NOx and N2O Axial Profiles in a Circulating Fluidized Bed Combustor显示文摘 | De Diego L F Londono C A Wang X S | 1996 | Fuel1996，75，8： | 1 |
| 20 | Stress-strain relationship in axial compression for concrete using recycledsaturated coarse aggregate显示文摘 | BELEN G F FERNANDO M A DIEGO C L | 2011 | Construction and Building materials2011，25，5： | 1 |
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