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| 1 | 行为安全“2-4”模型及其在煤矿安全管理中的应用显示文摘通过观察事故统计得知,几乎100%的生产安全事故是责任事故,且是由于事故单位的'管理漏洞'所引起。理论分析得知,应用古典、近代及已有的现代事故致因链不能够精确定位'管理漏洞'的具体位置和内容,事故预防困难。根据组织行为学原理,并研究国内外已有事故致因链发现并提出了行为安全'2-4'模型这个新型现代事故致因链。在该模型中,将事故的原因首先分解为组织行为、组织成员个人行为两个层面,然后再将组织行为继续细化分解为指导行为、运行行为,将个人行为细化分解为习惯性行为、一次性行为4个行为阶段,分别对应事故的根源、根本、间接、直接原因,具体内容分别是安全文化,安全管理体系,安全知识、意识和习惯,不安全动作和不安全状态。煤矿事故案例分析证实,应用该模型,且把'安全管理'表达为'行为控制'之后,可以将导致事故发生的关键原因'管理漏洞'、'管理缺欠'理解为'行为控制缺欠',并可将其精确定位在'2'个层面、'4'个行为阶段的其中一个或几个上面,据此即可制定有效、明确的事故预防措施。 | 傅贵 殷文韬 董继业 Di FAN Cherrie Jiuhua ZHU | 2013 | 煤炭学报2013，38，7： | 271 |
| 2 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 3 | BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘 | Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu | 2009 | Cell Research2009，19，4： | 44 |
| 4 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 5 | Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats显示文摘 | Qi ZHANG Guang-ji WANG Ji-ye A Di WU Ling-ling ZHU Bo MA Yu DU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 28 |
| 6 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 7 | Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine显示文摘Anther cuticle and pollen exine act as protective envelopes for the male gametophyte or pollen grain, but the mechanism underlying the synthesis of these lipidic polymers remains unclear. Previously, a tapetum‐expressed CYP703A3, a putative cytochrome P450 fatty acid hydroxylase, was shown to be essential for male fertility in rice(Oryza sativa L.). However,the biochemical and biological roles of CYP703A3 has not been characterized. Here, we observed that cyp703a3‐2 caused by one base insertion in CYP703A3 displays defective pollen exine and anther epicuticular layer, which differs from Arabidopsis cyp703a2 in which only defective pollen exine occurs. Consistently, chemical composition assay showed that levels of cutin monomers and wax components were dramatically reduced in cyp703a3‐2 anthers. Unlike the wide range of substrates of Arabidopsis CYP703A2, CYP703A3 functions as an in‐chain hydroxylase only for a specific substrate, lauric acid, preferably generating 7‐hydroxylated lauric acid. Moreover, chromatin immunoprecipitation and expression analyses revealed that the expression of CYP703A3 is directly regulated by Tapetum Degeneration Retardation, a known regulator of tapetum PCD and pollen exine formation. Collectively, our results suggest that CYP703A3 represents a conserved and diversified biochemical pathway for in‐chain hydroxylation of lauric acid required for the development of male organ in higher plants. | Xijia Yang Di Wu Jianxin Shi Yi He Franck Pinot Bernard Grausem Changsong Yin Lu Zhu Mingjiao Chen Zhijing Luo Wanqi Liang Dabing Zhang | 2014 | Journal of Integrative Plant Biology2014，56，10： | 21 |
| 8 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 9 | Wire electrochemical machining with axial electrolyte flushing for titanium alloy显示文摘Titanium and its alloys have found very wide application in aerospace due to their excellent characteristics although their processing is still a challenge. Electrochemical machining is an important issue in the fabrication of titanium and titanium alloys. Wire electrochemical machining (WECM) is mainly used for workpiece cutting under the condition of different thickness plates. It has a great advantage over wire electro-discharge machining, which is the absence of heat-affected zone around the cutting area. Moreover, the wire electrode in WECM could be used repetitively because it is not worn out. Thus, much attention has been paid to WECM. The effective way of removing electrolysis products is of importance to WECM. In this paper, the axial electrolyte flushing is presented to WECM for removing electrolysis products and renewing electrolyte. The Taguchi experiment is conducted to optimize the machining parameters, such as wire feedrate, machining voltage, electrolyte concentration, etc. Experimental results show that WECM with axial electrolyte flushing is a promising issue in the fabrication of titanium alloy (TC1). The feasibility of multi-wire electrochemical machining is also demonstrated to improve the machining productivity of WECM. | Qu Ningsong Fang Xiaolong Li Wei Zeng Yongbin Zhu Di | 2013 | Chinese Journal of Aeronautics2013，26，1： | 19 |
| 10 | Experimental research on electrochemical machining of titanium alloy Ti60 for a blisk显示文摘Ti60(Ti–5.6Al–4.8Sn–2Zr–1Mo–0.35Si–0.7Nd) is a high-temperature titanium alloy that is now used for important components of aircraft engines. Electrochemical machining(ECM) is a promising technique that has several advantages, such as a high machining rate, and can be used on a wide range of difficult-to-process materials. In this paper, orthogonal experiments are conducted to investigate ECM of Ti60, with the aim of determining the influences of some electrochemical process parameters on the surface roughness. The most important parameter is found to be the frequency of the pulsed power supply. It is found that using suitably optimized parameters for ECM can greatly decrease the surface roughness of a workpiece. A surface roughness of approximately 0.912 lm can be obtained with the following optimal parameters: Na Cl electrolyte concentration 13wt%, voltage20 V, pulse frequency 0.4 k Hz, duty cycle 0.3, temperature 23 °C, and anode feed rate 0.5 mm/min.Furthermore, blisk blades have been successfully processed using these optimized parameters. | Chen Xuezhen Xu Zhengyang Zhu Dong Fang Zhongdong Zhu Di | 2016 | Chinese Journal of Aeronautics2016，29，1： | 17 |
| 11 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 12 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 13 | Dihydromyricetin improves type 2 diabetes- induced cognitive impairment via suppressing oxidative stress and enhancing brain-derived neurotrophic factor-mediated neuroprotection in mice显示文摘类型 2 糖尿病 mellitus (T2DM ) 导致认知缺陷(CI ) ,但是为在 T2DM 的认知机能障碍没有有效 pharmacotherapies 或药。Dihydromyricetin (DHM ) 是从白蔹属 grossedentata 的叶子提取的自然 flavonoid 混合物并且包括抗氧化剂和反糖尿病有各种各样的药理学效果。因此,我们在 T2DM 老鼠模型和它的可能的机制在 CI 上调查了 DHM 的效果。导致 T2DM,老鼠用高糖、高脂肪的饮食被喂 8 个星期,由低剂量 streptozotocin (STZ ) 列在后面管理。在 T2DM 鼠标模型的成功的正式就职以后,鼠标与相等的体积分别地被对待盐(T2DM 组) , 125 mg/kg/d DHM (L-DHM 组) ,或 250 mg/kg/d DHM (H-DHM 组) 。在 16 星期 DHM 管理以后,身体重量(BW ) , fasting 血葡萄糖,血类脂化合物, intraperitoneal 葡萄糖忍耐(IPGT ) ,和认知功能是坚定的。然后,在在马头鱼尾的怪兽的氧化压力标记和导出大脑的神经营养的因素(BDNF ) 的表情的改变被调查。我们的调查结果证明 DHM 能显著地改善在 T2DM 老鼠的 CI 和反向的异常葡萄糖和类脂化合物新陈代谢,通过调停 BDNF 的 neuroprotection 的氧化应力和改进的抑制可能。在结论,我们的结果建议 DHM 是导致 T2DM 的认知机能障碍的处理的一个有希望的候选人。 | Hongyan Ling Zemei Zhu Jihua Yang Jianqin He Sisi Yang Di Wu Shuidong Feng Duanfang Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 14 |
| 14 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 15 | Trajectory control strategy of cathodes in blisk electrochemical machining显示文摘A turbine blisk, which combines blades and a disk together, is one of the most important components of an aero engine. In the process of blisk electrochemical machining (ECM), the sheet cathode, which is usually used as a tool electrode, has a complicated structure. In addition to that, the channel between the adjacent blades is narrow and twisted, so interference is apt to happen when the sheet cathode feeds into the channel. Therefore, it is important to choose suitable trajectory control strategy. In this paper, a new trajectory control strategy of the sheet cathode is presented and corresponding simulation analysis is conducted on the basis of an actual blisk model. The simulation results demonstrate that the sheet cathode can feed into the channel by a spatial line trajectory without interference. Moreover, the verification experiments are carried out according to the simulation. The experimental results show that the cathode can move into the channel without interference. It is verified that the new trajectory control strategy is correct and can be used in the blisk ECM process successfully. | Zhu Dong Zhu Di Xu Zhengyang Zhou Laishui | 2013 | Chinese Journal of Aeronautics2013，26，4： | 14 |
| 16 | Protective effect of recombinant human IL-1Ra on CCl_4-induced acute liver injury in mice显示文摘AIM: To evaluate the effects of positive regulation of recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury in mice induced by carbon tetrachloride (CCl 4 ). METHODS: Acute liver damage was induced by injecting 8-wk-old mice with CCl 4 1 mL/kg (1:3 dilution in corn oil) intraperitoneally (ip). Survival after liver failure was assessed by injecting 8-wk-old mice with a lethal dose of CCl 4 2.6 mL/kg (1:1 dilution in corn oil) ip. Mice were subcutaneously injected with 1 mg/kg recombinant human IL-1Ra twice a day after CCl 4 treatment for 5 d. Serum alanine amino transferase (ALT) and aspartate aminotransferase (AST) levels were determined with a commercial assay kit. Serum IL-1β, IL-1Ra levels were measured by enzyme-linked immunosorbent assay kit. Quantitative real-time polymerase chain reaction was used to determine liver IL-1β, IL-1Ra and IL-6 expression during CCl 4-induced acute liver injury. Liver sections were stained with hematoxylin-eosin. A histology-injury grading system was used to evaluate the degree of necrosis after acute liver injury. Proliferating cell nuclear antigen (PCNA) staining was used to evaluate the role of rhIL-1Ra in promoting hepatocyte proliferation. RESULTS: Quantitative analysis showed a higher level of IL-6 mRNA expression and reduced serum AST and ALT levels in the livers of the rhIL-1Ra-treated group at the early phase of CCl 4-induced acute liver injury. Histological examination indicated a decrease in centrilobular necrotic areas in mice treated with rhIL-1Ra, and a novel role of rhIL-1Ra in promoting hepatocyte proliferation was also supported by an increase of PCNA staining. All these results, accompanied by a strong survival benefit in rhIL-1Ra-treated vs PBS-treated groups, demonstrated that rhIL-1Ra administration ameliorated the histological damage and accelerated the regeneration and recovery process of the liver. CONCLUSION: rhIL-1Ra could be further developed as a novel therapeutic agent for the treatment of acute liver injury because of its ability to reduce hepatocellular damage and facilitate liver regeneration. | Zhu, Run-Zhi Xiang, Di Xie, Chao Li, Jing-Jing Hu, Jian-Jun He, Hong-Lin Yuan, Yun-Sheng Gao, Jin Han, Wei Yu, Yan | 2010 | World Journal of Gastroenterology2010，16，22： | 13 |
| 17 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 18 | Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling显示文摘Cellular metabolism has been shown to regulate differentiation and function of immune cells.Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments.NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials.However,the influences of tumor microenvironments on NKT cell functions remain unclear.In our studies,lactic acid in tumor microenvironments inhibited IFNγ and IL4 productions from NKT cells,and more profound influence on IFNγ was observed.By adjusting the pH of culture medium we further showed that,dysfunction of NKT cells could simply be induced by low extracellular pH.Moreover,low extracellular pH inhibited NKT cell functions by inhibiting mammalian target of rapamycin(mTOR) signaling and nuclear translocation of promyelocytic leukemia zinc-finger(PLZF).Together,our results suggest that tumor acidic microenvironments could interfere with NKT cell functions through metabolic controls. | Di Xie Shasha Zhu Li Bai | 2016 | Science China(Life Sciences)2016，59，12： | 13 |
| 19 | Effectiveness of Auricular Acupressure for Acute Postoperative Pain after Surgery: A Systematic Review and Meta-Analysis显示文摘Objective: To identify the effectiveness of auricular acupressure(AA) in patients with acute postoperative pain after surgery by systematic review. Methods: A search of randomized controlled trials was conducted in 5 English medical electronic databases and 4 Chinese databases. Two reviewers independently retrieved related studies, assessed the methodological quality, and extracted data with a standardized data form. Meta-analyses were performed using all time-points meta-analysis. Results: A total of 26 studies with 1,682 participants were included. Results showed that compared with conventional therapy, AA significantly improved the total effective rate [risk ratio=1.25, 95% confidence interval(CI), 1.13 to 1.37, P<0.0001; heterogeneity: P<0.0001, I^2=85%]. In the subgroup analysis, the results changed in different follow-up time and surgery categories. The pain relief in the AA group might be the most significant at 72 h after surgery(mean difference=–0.85, 95% CI, –1.20 to –0.50, P<0.0001) and in abdominal surgery(mean difference=–1.15, 95% CI, –1.41 to –0.90, P<0.0001). Sensitivity analysis demonstrated that the results of this meta-analysis were stable. No serious adverse effects were recorded. Conclusions: It was recommended to provide AA to patients with acute postoperative pain. However, a more accurate estimate of the effect requires further rigorously designed large-scale and high-quality RCTs for improving acute postoperative pain after surgery. | ZHONG Qin WANG Di BAI Ya-mei DU Shi-zheng SONG Yu-lei ZHU Jing | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 12 |
| 20 | Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury:a prospective,single-center and double-blind study显示文摘Cardiac troponin-I(cTnI) and-T(cTnT) are sensitive and specific markers of myocardial injury.However,the role of increased cTnI and cTnT in percutaneous coronary intervention(PCI)-related myocardial injury remains controversial.In this prospective,single-center and double-blind study,we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT(cTns) in PCI-related myocardial injury in a Chinese population.A total of 1,008 patients with stable angina pectoris and non-ST-segment elevation acute coronary syndrome were recruited.The levels of cTnI and cTnT were examined before and after PCI.All patients were followed up for26±9 months to observe the incidence of major adverse cardiac events(MACEs).Our results showed that postPCI cTnI and/or cTnT levels were increased to more than the 99^(th) percentile upper reference limit(URL) in 133(13.2%) patients,among which 22(2.2%) were more than 5×99^(th) percentile URL.By univariate analysis,an elevation in cTns after PCI was not an independent predictor of increased MACEs,HR 1.35(P = 0.33,95%CI:0.74-2.46).In conclusion,our data demonstrate that the incidence of PCI-related myocardial injury is not common in a Chinese population and minor elevated cTns levels may not be a sensitive prognostic marker for MACEs. | Min Zhang Huiwei He Ze-Mu Wang Zhihui Xu Ningtian Zhou Zhengxian Tao Bo Chen Chunjian Li Tiebing Zhu Di Yang Liansheng Wang Zhijian Yang | 2014 | The Journal of Biomedical Research2014，28，2： | 12 |
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