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| 1 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 2 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 3 | Selective transport of COa, ell4, and N2 in coals : Insights from modeling of experimental gas adsorption data显示文摘 | Cui X Bustin R M Dipple G | 2004 | Fuel2004，83，3： | 1 |
| 4 | Effective environmental interpretation at Chinese natural attractions: The need for an aesthetic approach显示文摘 | XU H G CUI Q M BALLANTYNE R PACKER J | 2012 | Journal of Sustainable Tourism2012，21，1： | 1 |
| 5 | The cytotoxic activity of ursolic acid derivatives 显示文摘 | Ma C M Cai S Q Cui J R | 2005 | Eur J Med Chem2005，40，： | 1 |
| 6 | Further comments on CIEDE2000显示文摘 | Luo M R Cui G Rigg B | 2002 | Color Res2002，27，2： | 1 |
| 7 | Impacts of volumetric strain on CO2 sequestration in coals and enhanced CH4 recovery 显示文摘 | Bustin R M Cui X J Chikatamarla L | 2008 | AAPG Bulletin2008，92，1： | 1 |
| 8 | Transgenic rice with a synthetic crylAb gene from Bacillus thuringiensis is highly resistant to eight lepidopteran insects显示文摘 | Shu Q Y Ye G Y Cui H R Cheng X Xiang Y Wu D Gao M Xia Y Hu C Sardana R Altosaar I | 2000 | Mol Breed2000，，6： | 1 |
| 9 | Semisynthesis and antifeedant ac- tivity of new acylated derivatives of Tutin,a sesquiterpene lac- tone from Coriaria sinica 显示文摘 | Li M L Cui J Qin R H | 2007 | Heterocycles2007，71，： | 1 |
| 10 | Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator- activated receptor-gamma 显示文摘 | Miksa M Wu R Cui X | 2007 | J Immunol2007，179，9： | 1 |
| 11 | Colour-difference evaluation using CRT colours ( part I) : data gathering 显示文摘 | CUI G LUO M R RIGG B | 2001 | Color Research & Application2001，26，5： | 1 |
| 12 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 13 | Compact finite difference method for the fractional diffusion equation显示文摘 | CUI M R | 2009 | J Comput Phys2009，228，： | 1 |
| 14 | New insight into the mechanism of cellulose and callose biosynthesis: Proteases may regulate callose biosynthesis upon wounding 显示文摘 | Nakashima J Laosinchai W Cui X J Brown R M | 2003 | Cellulose2003，10，： | 1 |
| 15 | Uniform Colour Spaces Based on CIECAM02 Colour Appearance Model 显示文摘 | LUO M R CUI G LI C | 2006 | Color Research and Application2006，31，4： | 1 |
| 16 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 17 | The Development of the CIE 2000 Colour-difference Formula: CIEDE2000 显示文摘 | LUO M R CUI G RIGG B | 2001 | Color Re- search and Application2001，26，5： | 1 |
| 18 | Cell-free DNA: Character- istics, Detection and its Applications in Myocardial Infarc- tion 显示文摘 | Jing R Cui M Wang H | 2013 | Curr Pharm Des2013，19，： | 1 |
| 19 | Multirate interacting multiple model particle filter for terrain based ground target tracking显示文摘 | HONG L CUI N BAKICH M LAYNE J R | 2006 | Control Theory and Applications IEE Proceedings2006，153，6： | 1 |
| 20 | In vivo cancer targeting and imaging with semiconductor quantum dots显示文摘 | Gao Xiaohu Cui Yuanyuan Levenson R M | 2004 | Nature Biotechnology2004，22，8： | 1 |
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