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| 1 | A unique clonal JAK2 mutati on leading to constitutive signalling causes poly-cythemia vera显示文摘 | James C Ugo V Le Coué dic J P | | 0，，： | 1 |
| 2 | Neighborhood Filters and PDE's 显示文摘 | A Buades B CoU J Morel | 2005 | Technical Report2005，2005，： | 1 |
| 3 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | Pasternack R F CoUings P J | 1995 | Science1995，269，： | 1 |
| 4 | A unique clonal JAK2 muta- tion leading to constitutive signaling causes polycythemia vera显示文摘 | James C Ugo V Le Cou e dic J P et aI | 2005 | Nature2005，434，7037： | 1 |
| 5 | Triptolide inhibits the growth and metastasis of solid tumors 显示文摘 | Yang S Chen J Cou Z | 2003 | Mol Cancer Therap2003，2，1： | 1 |
| 6 | Analysis of electromag- netic and thermal fields for a bus duct system显示文摘 | Hwang hang cou Chang J J Jiang Y H | 1998 | Electric Power Systems Research1998，45，1： | 1 |
| 7 | Recent advances and new insights in the management of early-stage epidermal growth factor receptor-mutated non-small-cell lung cancer显示文摘Patients with early-stage non-small-cell lung cancer(NSCLC)are candidates for curative surgery;however,despite multiple advances in lung cancer management,recurrence rates remain high.Adjuvant chemotherapy has been demonstrated to significantly prolong overall survival(OS),but this benefit is modest and there is an urgent need for effective new therapies to provide a cure for more patients.The high efficacy of tyrosine kinase inhibitors(TKIs)against epidermal growth factor receptor-mutated(EGFR)in patients with advanced EGFR-mutated NSCLC has led to the evaluation of these agents in early stages of the disease.Multiple clinical trials have evaluated the safety and efficacy of EGFR TKIs as an adjuvant treatment,in patients with resected EGFR-mutated NSCLC,and shown that they significantly prolong disease-free survival(DFS),but this benefit does not translate to OS.Recently,an interim analysis of the ADAURA trial demonstrated that,surprisingly,osimertinib improved DFS.This led to the study being stopped early,leaving many unanswered questions about its potential effect on OS and its incorporation as a standard adjuvant treatment in this patient subgroup.These targeted agents are also being evaluated in locally-advanced disease,with promising results,although prospective studies with larger sample sizes are needed to confirm these results.In this article,we review the most relevant studies on the role of EGFR TKIs in the management of early-stage EGFR-mutated NSCLC. | Miguel J Sotelo Jose Luis García Cesar Torres-Mattos Héctor Milián Carlos Carracedo María Angeles González-Ruiz Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，10： | 1 |
| 8 | Metabolic engineering of Saccharomyces cerevisiae to minimize the production of ethyl carbamate in wine显示文摘 | Cou J Husink JI Inglis DL | 2006 | Am J Enol Vitic2006，57，2： | 1 |
| 9 | A nonlocal algorithm for image denoising显示文摘 | Buades A CoU B and Morel J M | 2005 | IEEE Computer Society Conference on Computer Vision and Pattem Regcognition2005，2，： | 1 |
| 10 | Endothe Lia L cells and VEGF in vascu Lar deve Lopment显示文摘 | Cou Ltas L Chawengsaksophak K Rossant J | 2005 | Nature2005，438，7070： | 1 |
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