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| 1 | Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question显示文摘Non-alcoholic liver disease(NAFLD) defines liver abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in the absence of significant alcohol consumption, use of teratogenic medication, or hereditary disorders.The association between NAFLD and metabolic syndrome is well documented and widely recognized.Obesity, type 2 diabetes mellitus(T2DM), and dyslipidemia are the most common metabolic risk factors associated with NAFLD.Among the components of metabolic syndrome, current evidence strongly indicates obesity and diabetes as hepatocellular carcinoma(HCC) risk factors.There is also growing evidence that suggests an increased risk of HCC in NAFLD patients, even surpassing other etiologies in some high-income countries.Epidemiologic data demonstrate a parallel rise in prevalence of obesity, diabetes, NAFLD, and HCC.As obesity and its related diseases have steadily afflicted larger populations, HCC incidence is expected to increase in the future.Pathophysiologic mechanisms that underlie NAFLD development and subsequent progression to nonalcoholic steatohepatitis and cirrhosis(insulin resistance and hyperinsulinemia, oxidative stress, hepatic stellate cell activation, cytokine/adipocytokine signaling pathways, and genetic and environmental factors) appear to play a significant role in the development of NAFLD-related HCC.However, a comprehensive view of molecular mechanisms linking obesity, T2 DM, and NAFLD-related HCC, as well as the exact sequence of molecular events, is still not understood in its entirety.Good-quality data are still necessary, and efforts should continue towards better understanding the underlying carcinogenic mechanisms of NAFLD-related HCC.In this paper, we aimed to centralize the most important links supporting these relationships, focusing on obesity, T2 DM, and NAFLD-related HCC, as well as point out the major gaps in knowledge regarding the underlying molecular mechanisms behind them. | Letitia Adela Maria Streba Cristin Constantin Vere Ion Rogoveanu Costin Teodor Streba | 2015 | World Journal of Gastroenterology2015，21，14： | 15 |
| 2 | Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors显示文摘AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver tumors.METHODS:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,Romania.We recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC analysis.The difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver lesion.RESULTS:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive value.The artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive value.The accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase followed by wash-out in the portal and first seconds of the late phases.For the hypovascular metastases did not show significant contrast uptake during the arterial phase,which resulted in negative differences between the maximum intensities.We registered wash-out in the late phase for most of the hypervascular metastases.Liver hemangiomas had contrast uptake in the arterial phase without agent wash-out in the portallate phases.The focal fatty changes did not show any differences from surrounding liver parenchyma,resulting in similar TIC patterns and extracted parameters.CONCLUSION:Neural network analysis of contrastenhanced ultrasonography-obtained TICs seems a promising field of development for future techniques,providing fast and reliable diagnostic aid for the clinician. | Costin Teodor Streba Mihaela Ionescu Dan Ionut Gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Psychosocial stress and liver disease status显示文摘'Psychosocial stress' is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. | Cristin Constantin Vere Costin Teodor Streba Letitia Maria Streba Alin Gabriel Ionescu Felix Sima | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 4 | Numerical simulation of detonation of an explosive atmosphere of liquefied petroleum gas in a confined space显示文摘The detonation of an explosive atmosphere from liquefied petroleum gas disseminated in air in a confined space is studied using numerical modeling with software product ANSYS AUTODYN. | Niculae Serban COSTIN | 2014 | Defence Technology(防务技术)2014，10，3： | 4 |
| 5 | Injecting drug use: A vector for the introduction of new hepatitis C virus genotypes显示文摘Hepatitis C virus(HCV) genotypes' monitoring allows real-time insight into the dynamic changes that occur in the global epidemiological picture of HCV infection. Intravenous drug use is currently the primary driver for HCV transmission in developed and developing countries. The distribution of HCV genotypes/subtypes differs significantly between people who inject drugs(PWID) and the general population. HCV genotypes that previously exhibited a limited geographical distribution(3a,4) are becoming more prevalent in this high-risk group. Immigration from HCV-endemic countries and the evolving networks of HCV transmission in PWID influence HCV genotypes distribution in Europe. Social vulnerabilities(e.g.,unemployment,homelessness,and limited access to social and healthcare insurances systems) are important triggers for illicit drug use,which increases the associated risks of HCV infection and the frequent emergence of less prevalent genotypes. Genotype/subtype determination bears important clinical consequences in the progression of liver disease,susceptibility to antiviral therapies and the emergence of resistance-associated variants. An estimated half of the chronically HCV-infected PWID are unaware of their infection,and only one in ten of those diagnosed enter treatment. Nevertheless,PWID exhibit high response rates to new antiviral regimens,and the level of HCV reinfection is unexpectedly low. The focus of the healthcare system must be on the early detection and treatment of infection,to avoid late presentations that are associated with high levels of viremia and liver fibrosis,which may diminish the therapeutic success rate. | Simona Ruta Costin Cernescu | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 6 | Novel eco-efficient reactive distillation process for dimethyl carbonate production by indirect alcoholysis of urea显示文摘Dimethyl carbonate is an eco-friendly essential chemical that can be sustainably produced from CO_(2),which is available from carbon capture activities or can even be captured from the air.The rapid increase in dimethyl carbonate demand is driven by the fast growth of polycarbonates,solvent,pharmaceutical,and lithium-ion battery industries.Dimethyl carbonate can be produced from CO_(2)through various chemical pathways,but the most convenient route reported is the indirect alcoholysis of urea.Previous research used techniques such as heat integration and reactive distillation to reduce the energy use and costs,but the use of an excess of methanol in the trans-esterification step led to an energy intensive extractive distillation required to break the dimethyl carbonate-methanol azeotrope.This work shows that the production of dimethyl carbonate by indirect alcoholysis of urea can be improved by using an excess of propylene carbonate(instead of an excess of methanol),a neat feat that we showed it requires only 2.64 kW·h·kg^(-1) dimethyl carbonate in a reaction-separation-recycle process,and a reactive distillation column that effectively replaces two conventional distillation columns and the reactor for dimethyl carbonate synthesis.Therefore,less equipment is required,the methanol-dimethyl carbonate azeotrope does not need to be recycled,and the overall savings are higher.Moreover,we propose the use of a reactive distillation column in a heat integrated process to obtain high purity dimethyl carbonate(>99.8 wt-%).The energy requirement is reduced by heat integration to just 1.25 kW·h·kg^(-1) dimethyl carbonate,which is about 52%lower than the reaction-separation-recycle process.To benefit from the energy savings,the dynamics and control of the process are provided for10%changes in the nominal rate of 32 ktpy dimethyl carbonate,and for uncertainties in reaction kinetics. | Iulian Patrașcu Costin S.Bîldea Anton A.Kiss | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 2 |
| 7 | Techniques for bonding rubber to metal:Using metallic coagents显示文摘 | COSTIN R NAGEL W | 1999 | Kautschuk und Gummi Kunststoffe1999，52，3： | 1 |
| 8 | Monitoring the total phenolic/antioxidant levels in wine using flow injection analysis with acidic potassium permanganate chemiluminescence detection 显示文摘 | COSTIN J W BARNETT N W LEWIS S W | 2003 | AnalChimActa2003，499，： | 1 |
| 9 | A micro crack model for the deformation and failure of brittle rock显示文摘 | COSTIN L S | 1983 | Journal of Geophysical Research1983，88，11： | 1 |
| 10 | Neu- ron specific enolase, but not S100B or myelin basic pro- tein, ,increases in peripheral blood corresponding to lesion volume after cortical impact in piglets显示文摘 | Costine BA Quebeda-Clerkin PB Dodge CP | 2012 | J Neurotrauma2012，29，17： | 1 |
| 11 | Using neural networks and LPCC to improve speech recognition signals 显示文摘 | Zbaneioc M Costin M | 2003 | Proceedings of the International Symposium on Circuits and Systems2003，2，1： | 1 |
| 12 | Evolution of weld metal microstructure in shielded metal arc welding of XT0 HSLA steel with cellulosic electrodes: A case study 显示文摘 | GHOMASHCHI R COSTIN W KURJI R | 2015 | Materials Characterization2015，，107： | 1 |
| 13 | Geographic information systems in malaria surveillance:mosquito breeding and imported cases in Israel, 1992显示文摘 | Kitron U Penter H Costin C | 1994 | Am J Trop Med Hyg1994，50，1： | 1 |
| 14 | Human skin pigmentation: Melanocytes modulate skin color in response to stress显示文摘 | Costin G E Hearing V J | 2007 | The Journal of Federation of American Societies for Experimental Biology2007，21，4： | 1 |
| 15 | Human skin pigmentation:me|anocytes modulate skin color in response to stress 显示文摘 | Costin GE Hearing VJ | 2007 | FASEB J2007，21，4： | 1 |
| 16 | HELLP syndrome - a multi- systemic disorder显示文摘 | Mihu D Costin N Mihu CM | 2007 | J Gastrointestin Liver Dis2007，16，4： | 1 |
| 17 | Effect of melatonin on intra- abdominal fat in correlation with endometrial proliferation in ovariectomized rats显示文摘 | Giortea R Costin N Bracicu I | 2011 | Anticancer Res2011，31，8： | 1 |
| 18 | Neuron-specific eno- lase,but not S100B or myelin basic protein,increases in peripheral blood corresponding to lesion volume after cortical impact in piglets 显示文摘 | Costine BA Quebeda-Clerkin PB Dodge CP | 2012 | JNeurotrauma2012，29，17： | 1 |
| 19 | On the dynamics and control of a platicating extruder显示文摘 | Costin M H Taylor P A Wright J D | 1982 | Polymer Engineering and Science1982，22，17： | 1 |
| 20 | New metallic coagents for curing elastomers显示文摘 | Costin R Nagel W Ekwall R | 1991 | RubbChemTech1991，54，2： | 1 |
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