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| 1 | 一项中断时间序列研究与集群随机试验:减少耐药细菌在重症监护室中定植和传播的干预措施显示文摘背景 重症监护室(ICU)是耐药细菌传播的高危科室,在设置标准预防措施时缺乏对"全面筛查和隔离携带或感染耐药细菌者"效果评估的对照研究,本研究评估此干预措施对减少ICU中耐药细菌的定植与传播的效果. | 曾翠 吴安华 Derde L P G Cooper B S Goossens H | 2014 | 中国感染控制杂志2014，13，1： | 23 |
| 2 | 半嵌套式PCR检测转几丁质酶基因烟草研究显示文摘用含卡那霉素的培养基首先对转几丁质酶基因烟草种子和烟苗进行初步筛选鉴定 ,再用 Western Blot进一步证实抗卡那霉素的转基因烟苗中外源转几丁质酶基因的表达。然后研究半嵌套式 PCR(Semi- nested PCR)检测转几丁质酶基因烟草植株及其烤后烟叶中的所转目的基因 ;利用限制性内切酶 H ind 对半嵌套式 PCR产物进行酶切 ,从而验证半嵌套式 PCR产物是否为真正的目的基因。研究结果表明 ,半嵌套式 PCR是一种快速。 | 时焦 M Naylor M L Edwards J I Cooper 韩锦峰 | 2002 | 中国烟草学报2002，8，2： | 8 |
| 3 | 视网膜微血管异常与MRI确诊的亚临床脑梗死:动脉粥样硬化风险的社区研究显示文摘Background and Purpose-Retinal microvascular abnormalities reflect cumulative small vessel damage from elevated blood pressure and may reflect subclinical cerebral microvascular changes.We examined their associations with MRI-defined cerebral infarcts.Methods-Population-based,cross-sectional study of 1684 persons 55 to 74 years of age without a history of clinical stroke,sampled from 2 US southeastern communities.Retinal photographs were obtained and graded for presence of retinal microvascular abnormalities,including arteriovenous nicking,focal arteriolar narrowing,retinal hemorrhages,soft exudates and microaneurysms.Photographs were also digitized,and retinal vessel diameters were measured and summarized as the arteriole-to-venule ratio(AVR).Cerebral MRI scans were graded for presence of cerebral infarct,defined as a lesion ≥ 3 mm diameter in a vascular distribution with typical imaging characteristics.Results-There were a total of 183 MRI cerebral infarcts.After adjustment for age,gender,race,6-year mean arterial blood pressure,diabetes,and other stroke risk factors,cerebral infarcts were associated with retinal microvascular abnormalities,with odds ratios 1.90(95% CI,1.25 to 2.88)for arteriovenous nicking,1.89(95% CI,1.22 to 2.92)for focal arteriolar narrowing,2.95(95% CI,1.30 to 6.71)for blot hemorrhages,2.08(95% CI,0.69,6.31)for soft exudates,3.17(95% CI,1.05 to 9.64)-for microaneurysms,and 1.74(95% CI,0.95 to 3.21)for smallest compared with largest AVR.In stratified analyses,these associations were only present in persons with hypertension.Conclusions-Retinal microvascular abnormalities are associated with MRI-defined subclinical cerebral infarcts independent of stroke risk factors.These data suggest that retinal photography may be useful for studying subclinical cerebrovascular disease in population-based studies. | Cooper L S. Wong T. Y. Klein R. 王文军(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，9： | 6 |
| 4 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 5 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 6 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 7 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 8 | Load regulation of the properties of adult feline cardiocytes: growth induction by cellular deformation显示文摘 | Mann D L Kent R L Cooper G | 1989 | Circ Res1989，64，6： | 2 |
| 9 | Asymptotic behavior of an allocation policy for revenue management 显示文摘 | COOPER W L | 2002 | Operations Research2002，50，4： | 1 |
| 10 | Response of soybean cultivars to narrow row sand,planting rates under Weed-free conditions显示文摘 | Cooper R L | 1977 | Agronomy Journal1977，69，1： | 1 |
| 11 | Choosing weights from alternative optimal solutions of dual multiplier models in DEA显示文摘 | Cooper W W Ruiz J L | 2007 | European Journal of Operational Research2007，180，1： | 1 |
| 12 | Attenuation,persistence,and vaccine potential of an Edwardsiella ictaluri purA mutant显示文摘 | Lawrence M L Cooper R K Thune R L | 1997 | Infection and Immunity1997，65，11： | 1 |
| 13 | Manipulation of the n-3 PUFA content of muscle and adipose tissue in lambs显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | J Animal Sci2004，82，： | 1 |
| 14 | Postpartum depression and the mother - infant relationship in a South African peri - urban settlement 显示文摘 | Cooper PJ Tomlinson M Swartz L | 1999 | British Journal of Psychiatry1999，175，： | 1 |
| 15 | Further assess- ment of a three-component model of occupational commitment: generalize ability and differences across occupations显示文摘 | IRVING P G COLEMAN D F COOPER C L | 1997 | J Ap- plied Psychol1997，82，3： | 1 |
| 16 | Carbon deposition from propylene on polycrystalline and single crystal iron显示文摘 | COOPER B J TRIMM D L | 1980 | J Catal1980，62，1： | 1 |
| 17 | Spectroscopic ellipsometry study of the diluted magnetic semiconductor system Zn(Mn,Fe, Co)Se 显示文摘 | Kim Y D Cooper S L Klein M V | 1994 | Phys Rev B1994，49，3： | 1 |
| 18 | Researchin stress, coping and health Theoretical and methedologicalissues显示文摘 | Edwards J R Cooper C L | 1988 | Psychological Medicine1988，18，： | 1 |
| 19 | Real-time CORBA显示文摘 | Victor F W Dipippo L C Cooper G | 2000 | IEEE Transactions on Parallel and Distributed Systems2000，11，10： | 1 |
| 20 | Measures of Perrow's work unit technology : An empirical assessment and a new scale 显示文摘 | Withey M J Daft R L Cooper W H | 1983 | Academy of Management Journal1983，26，4： | 1 |
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