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| 1 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 2 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 3 | Effect of hypo-thyroidism and its treatment on the IGF system in infants andchildren显示文摘 | Purandare A Co Ng L Godil M | 2003 | J Pediatr Endocrinol Metab2003，16，1： | 1 |
| 4 | Improving detection limits for organotin compounds in several matrix water samples by derivatization-headspace-solid- phase microextraction and GC-MS 显示文摘 | SEGOVIA-MARTINEZ L BOUZAS-BLANCO A CAMPINS-FAL- CO P | 2010 | Talanta2010，80，5： | 1 |
| 5 | Risks associated with statin therapy: a systematic overview of randomized clinical trials显示文摘 | Kashani A Phillips CO Foody JM | 2006 | Circula- tion2006，114，25： | 1 |
| 6 | Prediction of arterial blood gas values from venous blood gas values in patients with acute exacer bation of cbronic obstructive pulmonary disease显示文摘 | Ak A Ogun CO Bayir A | 2006 | Tohoku J Exp Med2006，210，4： | 1 |
| 7 | Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis显示文摘 | Rajp A Adu D Savage CO | 2007 | Clin Exp Immunol2007，149，2： | 1 |
| 8 | Chronic hepatitis C and type Ⅱ diabetes mellitus: a prospective cross-sectional study显示文摘 | Zein CO Levy C Basu A | 2005 | Am J Gastroenterol2005，100，1： | 1 |
| 9 | Risk associated with statins therapy:a systematic overview of randomized clinical trial显示文摘 | Kashani A Phillips CO Foody JM | | 0，，25： | 1 |
| 10 | Racial differences in bone mineral density and bone loss among end-stage renal disease patients显示文摘 | Stehman-Breen CO Sherrard D Walker A | 1999 | Am J Kidney Dis1999，33，5： | 1 |
| 11 | Is radical lobectomy required in congenital cystic adenomatoid malformation显示文摘 | Muller CO Berrebi D Kheniche A | | 0，，04： | 1 |
| 12 | Chronic hepatitis C and type Ⅱ diabetes mellitus: a prospective cross-sectional study 显示文摘 | Zein CO Levy C Basu A | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 13 | Losses in high speed permanent magnet machines used in microturbine applications显示文摘 | Co H Zheng Liping Dipjyoti A | 2009 | Journal of Engineering for Gas Turbines and Power2009，，131： | 1 |
| 14 | The Robustness of CAN-Q in Modeling Automated Manufacturing Systems 显示文摘 | Co H C Wysk R A | 1986 | International Journal of production Research1986，，10： | 1 |
| 15 | New Fast GPS Code - Acquisition Technique Using FFT显示文摘 | Van Nee D J R Co - enen A J R M | 1991 | Electronic Letters1991，27，2： | 1 |
| 16 | Effect of nerve degeneration by 6-hydroxydopamine on catecholamine-stimulated adenosine 3',5'-monophosphate formation in rat cerebral cortex 显示文摘 | Kalisker A Rutledge CO Perkins JP | 1973 | Molecular Pharmacology1973，9，5： | 1 |
| 17 | Caries, periodontal and prosthet finding in patients with removable partial den- tures: a tenyear longitudinal study显示文摘 | Bergman B Hugoson A Olssion CO | 1982 | Prosthet Dent1982，48，1： | 1 |
| 18 | 5-Fluorouracil versus mito- mycin C as adjuncts to conjunctival autograft inpreventinN pterygium recurrence显示文摘 | Ekible CO Ashaye A Olusanye B | 2012 | Int Ophthalmol2012，32，1： | 1 |
| 19 | Toxoplasmosis in Mexico:epidemiological situation in humans and animals显示文摘 | Hernandez-Cortazar I Acosta-Viana KY Ortega-Pache- co A | 2015 | Rev Inst Med Trop Sao Paulo2015，57，2： | 1 |
| 20 | 基于家系的多学科综合干预的心血管疾病预防计划(EUROACTION):一项针对冠心病患者与心血管疾病高风险的无症状个体的配对、整群随机对照试验显示文摘背景:作者旨在研究一项基于家系的多学科综合干预的心脏学预防计划能否改善常规临床实践中的预防性护理标准。方法:在该项配对、整群随机对照试验中,8个欧洲国家的12家(6对)综合医院与12家(6对)全科诊疗中心被随机分配对冠心病患者或有心血管疾病高风险个体进行综合计划干预(INT)或常规护理(UC)。主要终点(干预1年后检测)为基于家系的生活方式改变,血压、血脂及血糖水平达到目标值,心脏保护药物的处方应用。 | D A Wood K Kotseva Co nnolly 李豪刚(译) | 2008 | 世界临床医学2008，2，5： | 1 |
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