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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 3 | Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis显示文摘 | Zhou JX Jia LW Liu WM Miao CL Liu S Cao YJ Duan EK | 2006 | 中国生物学文摘2006，20，5： | 8 |
| 4 | Electrochemical ageing study of mixed lanthanum/praseodymium nickelates La2-xPrxNiO4+δ as oxygen electrodes for solid oxide fuel or electrolysis cells显示文摘The chemical and electrochemical stability of lanthanide nickelates La2 NiO4+δ(LNO),Pr2 NiO4+δ(PNO)and their mixed compounds La(2-x)PrxNiO4+δ(LPNOs)with x=0.5,1 or 1.5 is reported.The aim is to promote these materials as efficient electrodes for solid oxide fuel cell(SOFC)and/or solid oxide electrolysis cell(SOEC).La2 NiO4+δand La1.5Pr0.5NiO4+δcompounds are chemically very stable as powders over one month in the temperature range 600-800℃,while the other materials rich in praseodymium progressively decompose into various perovskite-deriving components with additional Pr6 O11.Despite their uneven properties,all these materials are quite efficient and sustainable as electrodes on top of gadolinium doped ceria(GDCBL)//yttrium doped zirconia(8 YSZ)electrolyte,for one month at 700℃without polarization.Under polarization(300 mA·cm-2),the electrochemical performances of LNO,PNO and La1.5Pr0.5NiO4+δ(LP5 NO)quickly degrade in SOFC mode,i.e.for the oxygen reduction reaction,while they show durability in SOEC mode,i.e.for the oxide oxidation reaction. | Vaibhav Vibhu Aurélien Flura Aline Rougier Clément Nicollet Sébastien Fourcade Teresa Hungria Jean-Claude Grenier Jean-Marc Bassat | 2020 | Journal of Energy Chemistry2020，29，7： | 6 |
| 5 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 6 | 树突状细胞自然杀伤细胞凝集素群受体1促进小鼠动脉粥样硬化的发展显示文摘动脉粥样硬化发展过程中的坏死核心形成与慢性炎症反应有关,其促进斑块发展加快和不稳定。然而,坏死与动脉粥样硬化发展之间的分子生物学联系机制尚未完全清楚。 | 刘莉 叶鹏 Haddad Y Lahoute C Clément M Laurans L Metghalchi S Lynda Z Giraud A Loyer X Vandestienne M Wain-Hobson J Esposito B Potteaux S Ait-Oufella H Tedgui A Mallat Z Taleb S | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 7 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 8 | Framingham研究中年轻成人缺血性脑卒中发病的时间趋势显示文摘中年脑卒中对残疾造成的相关生活质量损失影响极大。在这个年龄段,缺血性脑卒中发病率可能会增加。该研究调查了按照中年和老年发病的脑卒中进行分层的社区样本中,缺血性脑卒中发病率和脑卒中危险因素变化的长期趋势。Framingham研究自1948年开始对脑卒中事件进行监测,研究人员对年龄35.<55和>55岁的患者开始进行随访观察,使用Cox模型检查经年龄和性别调整后的10年缺血性脑卒中发病率。在4个时期内进行线性趋势检验,并控制各期之间的时间距离。 | 刘莉(译) 叶鹏(审校) Aparicio HJ Himali JJ Satizabal CL Pase MP Romero JR Kase CS Beiser A S Seshadri S | 2019 | 中华高血压杂志2019，27，8： | 2 |
| 9 | 载脂蛋白E及脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病、死亡风险的关系显示文摘膳食脂肪对心血管健康和死亡率的作用仍然存在争议。由于载脂蛋白E(apolipoprotein E,APOE)是脂质运输和代谢的核心,研究者通过检测APOE—ε4基因型,评估了血浆脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病(冠心病)、死亡风险之间的关系。 | 刘青 叶鹏 Satizabal CL Samieri C Davis-Plourde KL Voetsch B Aparicio HJ Pase MP Romero JR Helmer C Vasan RS Kase CS Debette S Beiser AS Seshadr Sudhai | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 10 | Endogenous cannabinoids: A new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat显示文摘 | Josefa Ros Joan Clària Jordi To-Figueras Anna Planagumà Pilar Cejudo-Martin Guillermo Fernandez-Varo Raul Martín-Ruiz Vicente Arroyo Francisca Rivera Juan Rodés Wladimiro Jimenez | 2002 | Gastroenterology2002，，1： | 2 |
| 11 | Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells显示文摘 | Ryter SW Xi S Hartsfield CL | 2002 | Antioxid Redox Signal2002，4，4： | 1 |
| 12 | Predicting mortality in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention(PAMI risk soore)显示文摘 | Addala S Grines CL Dixon SB | 2004 | Am J Cardiol2004，93，5： | 1 |
| 13 | Differentiating human multipotent mesenchymal stromal cells regulate microRNAs:Prediction of microRNA regulation by PDGF during osteogenesis显示文摘 | Goff LA Boucher S Ricupero CL | 2008 | Exp Hematol2008，36，： | 1 |
| 14 | Nurses implementation of guidelines for ventilator-associated from the centers for disease control and prevention显示文摘 | Cason Cl Tyner T Saunders S | 2007 | Am J Crit Care2007，16，1： | 1 |
| 15 | DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells 显示文摘 | Arlander S J Greene BT Innes CL | 2008 | Cancer Research2008，68，1： | 1 |
| 16 | dl-3 n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP 显示文摘 | Liu CL Liao S J Zeng JS | 2007 | J Neurol Sei2007，260，12： | 1 |
| 17 | Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment显示文摘 | Mukherjee S Partch CL Lehotzky RE | 2009 | J Biol Chem2009，284，48： | 1 |
| 18 | A new portal for gynecologic laparoscopy显示文摘 | Lee CL Jain S Wang CJ | 2001 | J Am Assoc Gynecol Laparosc2001，18，1： | 1 |
| 19 | Locally administered anfiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery显示文摘 | Kennedy S Wadsworth RM and Wainwright CL | 2006 | Vascul Pharmacol2006，44，5： | 1 |
| 20 | Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre-and post-liver transplantation patients显示文摘 | Schiff ER Lai CL Hadziyannis S | 2003 | Hepatology2003，38，： | 1 |
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