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| 1 | Relationship between the temporal-spatial distribution of archaeological sites and natural environment from the Paleolithic Age to the Tang and Song Dynasties in the Three Gorges Reservoir of Chongqing area显示文摘The temporal-spatial distribution features including time distribution,horizontal and vertical spatial distribution of archaeological sites from the Paleolithic Age to the Tang and Song Dynasties in the Three Gorges Reservoir of Chongqing area are analyzed based on GIS spatial analysis.The successive pollen record of deposited peat stratum since the Paleolithic Age in the Dajiuhu Basin of Shennongjia is used in combination with the research of the historical environmental evolution to reconstruct the Paleoenvironment in the Three Gorges Reservoir of Chongqing area.Through the comparison of the temporal-spatial distribution of the archaeological sites and the natural environment,the relation between the distribution of the archaeological sites and the natural environment evolution and disaster changes from the Neolithic Age to the Tang and Song Dynasties has been discussed.Study shows that 677 archaeological sites from the Paleolithic Age to the Tang and Song Dynasties in the Three Gorges Reservoir of Chongqing area increase gradually from west to east and from high land to low land.Most of the sites are distributed along the river and aggregated at the confluence.Obviously,the altitudes of archaeological sites in the Paleolithic Age and the Neolithic Age are much higher than those of historical sites.The analysis suggests:(1)the human beings of every times would like to choose the first or the second river terrace as living sites which are nearer to the water source and are easier to with- stand flood.The pre-historical sites of earlier ages are often located at the higher altitude place because of the tectonic uplift and downcutting of rivers since Holocene.(2)Due to the rugged terrain in Chongqing area,most of the sites are located along the river sides,for example,the wide river valley and terrace,which could provide wider living space caused by the lateral erosion and deposition of the river course.(3)The early residents mainly relied on fishing,hunting and agriculture,and the rugged terrain of the mountainous area restricted the development of farming.However,in the confluence region,the fertilized plain provided an ideal location for farming and fishing.(4)The temporal-spatial distribution of archeological sites in this area is significantly affected by the climate condition. | ChaoGui Zheng Cheng Zhu YiShun Zhong PengLian Yin JiuJiang Bai ZhiBin Sun | 2008 | Chinese Science Bulletin2008，53，S1： | 11 |
| 2 | Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese显示文摘Apoptosis plays a key role in inhibiting tumor growth, progression and resistance to anti-tumor therapy. We hypothesized that genetic variants in apoptotic genes may affect the prognosis of lung cancer. To test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (SNPs) from 12 genes (BAX, BCL2, BID, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, FAS, FASLG and MCL1) involved in apoptosis to assess their prognostic significance in lung cancer in a Chinese case cohort with 568 non-small cell lung cancer (NSCLC) patients. Thirty-five SNPs passing quality control underwent association analyses, 11 of which were shown to be significantly associated with NSCLC survival (P<0.05). After Cox stepwise regression analyses, 3 SNPs were independently associated with the outcome of NSCLC (BID rs8190315: P=0.003; CASP9 rs4645981: P=0.007 and FAS rs1800682: P=0.016). A favorable survival of NSCLC was significantly associated with the genotypes of BID rs8190315 AG/GG (adjusted HR=0.65, 95% CI: 0.49-0.88), CASP9 rs4645981 AA (HR=0.22, 95% CI: 0.07-0.69) and FAS rs1800682 GG (adjusted HR=0.67, 95% CI: 0.46-0.97). Time-dependent receptor operation curve (ROC) analysis revealed that the area under curve (AUC) at year 5 was significantly increased from 0.762 to 0.819 after adding the risk score of these 3 SNPs to the clinical risk score. The remaining 32 SNPs were not significantly associated with NSCLC prognosis after adjustment for these 3 SNPs. These findings indicate that BID rs8190315, CASP9 rs4645981 and FAS rs1800682 polymorphisms in the apoptotic pathway may be involved in the prognosis of NSCLC in the Chinese population. | Songyu Cao Cheng Wang Xinen Huang Juncheng Dai Lingmin Hu Yao Liu Jiaping Chen Hongxia Ma Guangfu Jin Zhibin Hu Lin Xu Hongbing Shen | 2013 | The Journal of Biomedical Research2013，27，3： | 6 |
| 3 | Animal diversities and characteristics of environmental change revealed by skeletons unearthed at Zhongba Site of Chongqing City,China显示文摘Nearly 200000 animal skeletons are unearthed in the Unit T0202 from Zhongba Site of Zhongxian County.According to the analysis of 129165 specimens,these skeletons may be classified into 5 kinds, namely,Mammalia,Osteichthys,Aves,Amphibian and Reptilia,which belong to 13 orders,28 families and 42 genera.In this paper,based on archeological dating and AMS 14 C data,through statistically analyzing the unearthed skeletons and studying the change of the smallest individual numbers,these research results detected the following:1)In almost all the time of 2370―200 BC,in Zhongba region, some animals distributed widely,such as Muntiacus sp,Elaphodus cephalophus and Muntiacus sp. inhabiting in glade and grassland,Scrofa sp.and Canis familiaris raised by the ancient people,rodentia rabbit and Rattus rattus,which suggested that a fairly good ecological environment of forest and grassland was preserved at that period and the predecessors began to raise domestic animals from 1750 to 1000 BC,which has lasted until today.2)Rhinoceros only lived during 2000―1750 BC,1000― 700 BC and 700―500 BC,which indicates that the ecological environment of grassland and wetland might be better in these phases.3)Macaca sp.and Ursus arctos appeared only after 1750―1000 BC, which may show that the forest condition is better for animals to live during 1750―200 BC.4)The smallest individual numbers of Bublus sp.,bos sp.and otters emerged during about 2370―1750 BC, which perhaps infers that water area during the early period was wider than that of the late period.5) Since skeletons of rhinoceros are discovered in strata of Zhongba Site during 2000―1750 BC and 1000―500 BC,according to the climate and ecology environment which rhinoceros live in now,the average annual temperature and precipitation during 2000―1750 BC and 1000―500 BC are supposed to be probably higher than that of today.Although Zhu Kezhen considered that the first low temperature period in the past 5000 years of China was between 1100 BC and 850 BC,massive pollen of Morus, Ulmus,Fagus,Quercus,Castanea,etc.were found in Dajiuhu peat at that time,which should indicate that the climate was still moderate for living things to live at least in Dajiuhu basin and Zhongba Site.6) Because skeletons of Gervus albirostris were unearthed during 310―200 BC at Zhongba Site,based onthe climate and the ecological environment those animals live in now,the average annual temperature and the average annual precipitation in Zhongba area between 310 BC and 200 BC should be lower than those of today,which is confirmed by the TOC research of Zhongba Site strata. | ZHU Cheng MA ChunMei OUYANG Jie LI ZhongXuan YIN Qian SUN ZhiBin HUANG YunPing R.K.FLAD LI Lan LI YuMei | 2008 | Chinese Science Bulletin2008，53，S1： | 4 |
| 4 | Reconstructing past subsistence patterns on Zhongba Site using stable carbon and oxygen isotopes of fossil tooth enamel显示文摘The oxygen and carbon isotopic ratios in human and animal tooth enamel were measured to reconstruct the subsistence patterns on Zhongba Site between 2400 and 4200 aBP.The results indicate that human consumed chiefly C4 resources,such as millet,and the C3 plants,such as rice and wheat,constituted only a small fraction of the human diets,normally no more than 15%.There are significant differences in food sources between human and pig,and the percentages of C3 plants in pig diets were higher than those in human diets.But theδ13C values of pig partially overlap those of human,demonstrating some similarities in their food sources.The differences in water sources between human and pig are significant.There are significant differences in food and water sources between cattle and deer. This indicates that the two kinds of mammals subsisted in different niches.But theirδ13C values also partially overlap each other,suggesting some similarities in their food sources.There are both signifi- cant differences in meanδ13C andδ18O values between the omnivores,human and pig and the herbi- vores,cattle and deer,implying significant differences in food and water sources between the two categories.During the period the dietary habits of human had not changed,but the pig breeding strategies had changed,from breeding in house to breeding in confinement,and the proportion of C3 plants in pig food increased with time.The scope of human migration had been considerably large by the Warring States because of the development of productive forces. | XiaoSi Tian Cheng Zhu XinWang Xu ChunMei Ma ZhiBin Sun Qian Yin Qing Zhu Wei Shi | 2008 | Chinese Science Bulletin2008，53，S1： | 4 |
| 5 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 6 | Rise and decline of ancient salt industry revealed by Na and Ca concentrations in sediments at Zhongba site, Chongqing显示文摘基于皇朝的时期分割和 AMS 14 标明日期的 C 在 Zhongba 和 Yuxi 地点表现在沉积的层上,并且另外从 Zhongba 地点和的 201 件沉积样品的 Na, Ca 和 Mg 的分析在 47 沉积 sampl 的 Ca 和 | ZHU Cheng JIANG Fengqing MA Chunmei XU Weifeng HUANG Linyan ZHENG Chaogui LI Lan SUN Zhibin | 2008 | Journal of Geographical Sciences2008，18，3： | 4 |
| 7 | RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer显示文摘Triple negative breast cancer(TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC. Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas(TCGA). Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes. Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis. In this report, we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways, suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types. Further survival analysis revealed that nine genes(FSIP1, ADCY5, FSD1, HMSD, CMTM5, AFF3, CYP2 A7, ATP1 A2,and C11 orf86) were significantly associated with the prognosis of TNBC patients, while three of them(ADCY5,CYP2 A7, and ATP1 A2) were involved in the hormone-related pathways. These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC. | Fei Chen Yuancheng Li Na Qin Fengliang Wang Jiangbo Du Cheng Wang Fangzhi Du Tao Jiang Yue Jiang Juncheng Dai Zhibin Hu Cheng Lu Hongbing Shen | 2020 | The Journal of Biomedical Research2020，34，2： | 4 |
| 8 | Composite Sinusoidal Nanograting With Long-Range SERS Effect for Label-Free TNT Detection显示文摘一合成一个维(1D ) 瞄准没有标签的表面的 Ag 正弦曲线 nanograting 提高了散布的拉曼(重量的单位) 有柔韧、可再现的改进的 TNT 的察觉被讨论。周期的正弦曲线 SiO 2 栅栏由 Ag 蒸发跟随了的 1D 基于表面电浆子电磁声子(SPP ) 为可再现、有效的重量的单位底层的创造被建议。1D 正弦曲线 nanograting 和它的远程的重量的单位效果的最佳的结构被使用有限差别时间领域(FDTD ) 分析。模拟重量的单位改进因素(EF ) 能是同样可能的 5 个数量级。这重量的单位底层被干扰影印石版术技术准备,它的重量的单位表演被 Rh6G 察觉实验测试,并且实际测试 EF 是大约 10 4 。TNT 的没有标签的重量的单位察觉能力在实验被表明。 | Cheng XIAO Zhibin CHEN Mengze QIN Dongxiao ZHANG Lei FAN | 2018 | Photonic Sensors2018，8，3： | 4 |
| 9 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 10 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 3 |
| 11 | Marine Mobile Wireless Channel Modeling Based on Improved Spatial Partitioning Ray Tracing显示文摘In 5G era,it is expected to achieve wireless network coverage including offshore areas.Modeling of marine wireless channels is the basis of constructing a marine communication system.In this paper,a communication scene between an unmanned aerial vehicle(UAV)and a boat is simulated to study the marine wireless channel.Firstly,an improved spatial partitioning ray tracing algorithm is proposed to track the propagation path of electromagnetic waves at sea surface.Secondly,a mobile channel is simulated and modeled based on the track results.Finally,a loss measurement is carried out in the coastal waters based on the simple wireless channel loss measuring platform,and a path loss propagation model is built.Then we compare the actual measurement data with the simulation results and find that the two are have good consistency,which further verifies the reliability of the simulation. | Zhibin Gao Bang Liu Zhipeng Cheng Canbin Chen Lianfen Huang | 2020 | China Communications2020，17，3： | 3 |
| 12 | PNAS:科学家发现新的精子运动调节器显示文摘南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院MartinM.Matzuk课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1,结果发表于《美国科学院院刊》(PNAs)。 | Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 13 | Labeled box-particle CPHD filter for multiple extended targets tracking显示文摘In multiple extended targets tracking, replacing traditional multiple measurements with a rectangular region of the nonzero volume in the state space inspired by the box-particle idea is exactly suitable to deal with extended targets, without distinguishing the measurements originating from the true targets or clutter.Based on our recent work on extended box-particle probability hypothesis density(ET-BP-PHD) filter, we propose the extended labeled box-particle cardinalized probability hypothesis density(ET-LBP-CPHD) filter, which relaxes the Poisson assumptions of the extended target probability hypothesis density(PHD) filter in target numbers, and propagates not only the intensity function but also cardinality distribution. Moreover, it provides the identity of individual target by adding labels to box-particles. The proposed filter can improve the precision of estimating target number meanwhile achieve targets' tracks. The effectiveness and reliability of the proposed algorithm are verified by the simulation results. | ZOU Zhibin SONG Liping CHENG Xuan | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 3 |
| 14 | Subcellular chemical imaging of structurally similar acridine drugs by near-field laser desorption/laser postionization mass spectrometry显示文摘Insights into the pharmacologic effect on cellular processes and the potential toxicological effects are vital to new drug development and evaluation,yet research on these subjects remains a great challenge due to the lack of information regarding the spatiotemporal distribution of drugs and metabolites within a single cell.Mass spectrometry imaging(MSI)has proven to be a label-free and high-throughput approach for visualizing drug distribution in spatial and temporal domains.However,single-cell drug imaging has been limited so far by detection sensitivity and microscale lateral resolution.Herein,we report near-field laser desorption/laser postionization mass spectrometry(NDPI-MS)for single-cell imaging of two structurally similar drugs,proflavine and ethacridine,and subcellular distributions of proflavine at different drug concentrations were investigated.The NDPI-MS imaging results indicate that proflavine was accumulated in lysosomes,which was verified by laser scanning confocal microscopy(LSCM).Additionally,a distinguished subcellular distribution pattern of ethacridine from proflavine could be visualized,highlighting the complexity of the interaction between the drugs and biological environment even though these two drugs possess similar structures.Taken together,the present results demonstrate the great potential of the integrated single-cell MSI platform for characterizing the drug distribution and its phenotype changes within individual cells,expediting the identification and evaluation of newly developed drugs. | Xiaoling Cheng Zhibin Yin Liu Rong Wei Hang | 2020 | Nano Research2020，13，3： | 3 |
| 15 | Potential of cellulose-based materials for lithium-ion batteries(LIB)separator membranes显示文摘Lithium-ion batteries(LIB)are the dominant power sources for many consumer electronics,and they can also be large-scale power sources/energy storage devices,which can be credited to their advantages:high efficiency,high energy density,long cycling life.The separator membrane is a critical component of LIB.It is an electron insulator between the cathode and anode electrodes in order to prevent electrical short circuits,and it also functions as an ionic conductor to let ions pass freely in the charging and discharging cycles.The critical parameters to meet high quality separator membranes include:high dimensional/thermal/chemical stability,good wettability towards electrolyte,high mechanical strength,appropriate porosity and pore size distribution.Conventionally,plastic materials,such as polyolefin,are the main materials for manufacturing LIB separator membrane.However,polyolefin separator s have a number of drawbacks such as poor thermal stability and wettability.Cellulosic materials have unique properties,and can meet the quality specifications of LIB separator membranes;in addition,they are abundant,low cost,biodegradable,renewable and sustainable.Therefore,cellulose and its related materials can be promising alternatives to replace polyolefin for LIB separator membranes.In this short review,relevant literature on the topic was reviewed and further development/improvement of cellulose-based LIB separator membrane will be discussed. | Dong Cheng Xue Yang Zhibin He Yonghao Ni | 2016 | Journal of Bioresources and Bioproducts2016，1，1： | 2 |
| 16 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 17 | Boosting Lean Electrolyte Lithium-Sulfur Battery Performance with Transition Metals: A Comprehensive Review显示文摘Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyzes the effect of the electrolyte-to-sulfur(E/S) ratios on battery energy density and the challenges for sulfur reduction reactions(SRR) under lean electrolyte conditions. Accordingly, we review the use of various polar transition metal sulfur hosts as corresponding solutions to facilitate SRR kinetics at low E/S ratios(< 10 μL mg~(-1)), and the strengths and limitations of different transition metal compounds are presented and discussed from a fundamental perspective. Subsequently, three promising strategies for sulfur hosts that act as anchors and catalysts are proposed to boost lean electrolyte Li–S battery performance. Finally, an outlook is provided to guide future research on high energy density Li–S batteries. | Hui Pan Zhibin Cheng Zhenyu Zhou Sijie Xie Wei Zhang Ning Han Wei Guo Jan Fransaer Jiangshui Luo Andreu Cabot Michael Wübbenhorst | 2023 | Nano-Micro Letters2023，15，10： | 2 |
| 18 | Relations between man and nature reflected by the evolution of the Neolithic production tools in the Three Gorges region of Yangtze River,China显示文摘The relations between man and nature reflected by evolution of Neolithic production tools in the Three Gorges region of Yangtze River is discussed in this paper.Our results show that there is a good correlation between the percentage vibration of cutting tool types and the environmental evolution indicated by the natural profile nearby.It is possible for ancestors from the Three Gorges region to learn the advantage of mortise and tenon in the early Neolithic Age because they used the stones as vital tools for processing woods.The hunting method in the early Neolithic is throwing,which was inherited in the mid-Neolithic Age when hunting with arrow and bow was developed.Fishing tools are found at the same period.Numbers of net sinkers and spinning wheels unearthed from the strata of the Western Zhou Dynasty from Zhongba Site reveal the fact of fishing with net,while a mass of fishbone pits indi- cate the powerful productivity brought by new production tools.Quantity of stone spades and stone hoes proves that cultivation agriculture by hoe is extremely attached importance by the ancestors in the Three Gorges region.Moreover,the developed agriculture in Daxi Culture at Zhongbao Island benefits from the landform,climate,traffic location,etc.Otherwise,the reason that the farming tools declined in the late Neolithic Age is related to the extreme flood during the early Xia Dynasty and the fishing hunting preference of some ancient settlements.This research shows that ancestors of the Three Gorges region during the Neolithic Age attached importance to fish hunting and cultivation, fought against the natural environment by production tools,constantly created and improved them, then comprehensively utilized them to evolve the relations between man and nature. | GuangYao Zhu Cheng Zhu GuangYue Shi ZhiBin Sun | 2008 | Chinese Science Bulletin2008，53，S1： | 2 |
| 19 | Carbon and nitrogen stable isotope analyses of mammal bone fossils from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River,China显示文摘Based on AMS 14 C dating data,carbon and nitrogen isotope analyses were conducted on mammal bone collagen of deer,cattle and pigs from the Zhongba site in the Three Gorges Reservoir region of the Yangtze River.These analyses were conducted to reconstruct palaeodiets of mammals,palaeoecology,palaeoenviroment and previous human activities in the study area.Results show that the collagen loss of bone did not change the in vivo isotopic composition of carbon and nitrogen stable isotopes,and most of the bone fossils were well preserved.The bone collagen of samples from deer had a mean δ 13 C of-23.1‰ and a mean δ 15 N of 4.7‰,suggesting that deer subsisted in a closed habitat and fed on branches and leaves.The bone collagen of cattle had a mean δ 13 C of-19.6‰ and a mean δ 15 N of 5.2‰,which indicates that cattle subsisted in an open habitat and fed on grasses and stems.The δ 13 C values show that both deer and cattle fed on C 3 plants and lived in the same ecosystem,but the t-test results show that deer δ 13 C and δ 15 N values were both more negative than those of cattle,indicating that they inhabited different niches.The δ 13 C and δ 15 N values of cattle partially overlapped those of deer,suggesting some competition in diets between them.The t-tests show that the δ 13 C and δ 15 N values of pigs were more positive than those of cattle and deer,which signifies that pigs occupied a higher trophic level compared to cattle and deer.The wide range of pig δ 13 C values demonstrates that pig trading had been taking place from early Neolithic Age to late Bronze Age.There were no significant differences in deer δ 13 C and δ 15 N values among different archaeological periods,making it clear that climatic,ecological and environmental conditions were kept relatively stable from 2200 to 4200 a BP.This stability may have been responsible for the extensive and complete cultural layers at the Zhongba site.The minimum number of samples required to estimate the mean δ 13 C values of deer,pigs and cattle are 8,73 and 16,respectively,and for mean δ 15 N values of deer,pigs and cattle,the minimum numbers are 4,5 and 6,respectively. | TIAN XiaoSi ZHU Cheng SUN ZhiBin SHUI Tao HUANG YunPing FLAD Rowan Kimon LI YuMei | 2011 | Chinese Science Bulletin2011，56，2： | 2 |
| 20 | The cancer-testis gene,MEIOB,sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency显示文摘Objective:The newly defined cancer-testis(CT)gene,MEIOB,was previously found to play key roles in DNA double-strand break(DSB)repair.In this study,we aimed to investigate the effects and mechanisms of MEIOB in the carcinogenesis of triple-negative breast cancers(TNBCs).Methods:The Cancer Genome Atlas database was used to quantify the expression of MEIOB.Cox regression analysis was used to evaluate the association between MEIOB expression and the prognosis of human TNBC.The effects of MEIOB on cell proliferation and migration in TNBCs were also assessed in vitro.Patient-derived xenograft(PDX)models were used to assess the sensitivity of breast cancers with active MEIOB to PARP1 inhibitors.Results:We confirmed MEIOB as a CT gene whose expression was restricted to the testes and breast tumors,especially TNBCs.Its activation was significantly associated with poor survival in breast cancer patients[overall,hazard ratio(HR)=1.90(1.16–2.06);TNBCs:HR=7.05(1.16–41.80)].In addition,we found that MEIOB was oncogenic and significantly promoted the proliferation of TNBC cells.Further analysis showed that MEIOB participated in DSB repair in TNBCs.However,in contrast to its function in meiosis,it mediated homologous recombination deficiency(HRD)through the activation of poly ADP-ribose polymerase(PARP)1 by interacting with YBX1.Furthermore,activated MEIOB was shown to confer sensitivity to PARP inhibitors,which was confirmed in PDX models.Conclusions:MEIOB played an oncogenic role in TNBC through its involvement in HRD.In addition,dysregulation of MEIOB sensitized TNBC cells to PARP inhibitors,so MEIOB may be a therapeutic target of PARP1 inhibitors in TNBC. | Yayun Gu Cheng Wang Rongxuan Zhu Jianshui Yang Wenwen Yuan Yanhui Zhu Yan Zhou Na Qin Hongbing Shen Hongxia Ma Hongxia Wang Xiaoan Liu Zhibin Hu | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
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