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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | 急性缺血性卒中低剂量组织型纤溶酶原激活物静脉溶栓:备选还是新标准?显示文摘组织型纤溶酶原激活物(tissue plasminogen activator,t PA)静脉溶栓是目前唯一被证实对急性缺血性卒中(acute ischemic stroke,AIS)有效的内科治疗手段,但tPA最佳剂量问题一直存在争议,国际脑血管病指南推荐采用标准剂量(0.9 mg/kg)治疗。由于种族差异等因素,有人认为亚洲AIS患者选择低剂量tPA可能更为合适。 | dong y cao w cheng x 张玉生 | 2018 | 中国卒中杂志2018，13，2： | 2 |
| 3 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 4 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 5 | Effects of biological soil crusts on emergence of desert vascular plants in North China显示文摘 | Su Y G Li X R Cheng Y W | 2007 | Plant ecology2007，191，： | 1 |
| 6 | Thermite reactions of Al/Cu core-shell nanocom posites with WO3 显示文摘 | Wang Y Jiang W Cheng Z P | 2007 | Thermoe-im Acta2007，463，1： | 1 |
| 7 | Expression of VGLUTs contributes to degeneration and acquisition of learning and memory 显示文摘 | Cheng X R Yang Y Zhou W X | 2011 | Neurobiol Learn Mem2011，95，： | 1 |
| 8 | High corrosion resistance of electroless composite plating coatings on AZ91D magnesium alloys显示文摘 | SONG Y W SHAN D Y CHENG R S | 2008 | Electrochimica Acta2008，53，5： | 1 |
| 9 | A DNA vaccineagainst Foot-and-mouth disease elicits an immune response in swine which is enhanced by co-admlnistration with interleukln-2显示文摘 | Wong HT Cheng SC S Sin F W Y | 2002 | Vaccine2002，20，： | 1 |
| 10 | Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity 显示文摘 | Cheng Y L Chang W L Lee S C | 2003 | Life Sci2003，73，18： | 1 |
| 11 | Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of herpes simplex virus type 1VP22 protein to antigen显示文摘 | Cheng W F Hung C F Chai C Y | 2001 | J Virol2001，75，5： | 1 |
| 12 | A study in Htro on differ- entiation of bone marrow mesenchymal stem cells into endometrial epi- thelial ceils in mice显示文摘 | Zhang W B Cheng M J Huang Y T | 2012 | Eur J Obstet Gynecol Reprod Binl2012，160，2： | 1 |
| 13 | Family Ownership and the Interna- tional Involvement of Taiwan's High -technology Firms: The Moder- ating Effect of High - discretion Organizational Slack 显示文摘 | Liu Y S Lin W T Cheng K Y | 2011 | Manage- ment and Organization Review2011，7，2： | 1 |
| 14 | Direct SERS detection of contaminants in a complex mixture:rapid,single step screening for melamine in liquid infant formula显示文摘 | Betz J F Cheng Y Rubloff G W | 2012 | Analyst2012，137，： | 1 |
| 15 | A multidomain boundary element solution for silencer and muffler performance prediction显示文摘 | Cheng C Y R Seybert A F Wu T W | | 0，，1： | 1 |
| 16 | Ozone-assisted UV254 nm photodegradation of gaseous ethylbenzene and chlorobenzene: effects of process parameters, degradation pathways, and kinetic analysis 显示文摘 | Cheng Z W Sun P F Jiang Y F | 2013 | Chem Eng J2013，228，： | 1 |
| 17 | Detection of reactive oxygen species ( ROS ) generated by TiOz ( R ) , TiO2 ( R/A ) and TiO2 (A) under ultrasonic and solar light irradiation and application in degradation of organic dyes显示文摘 | Guo Y W Cheng C P Wang J | 2011 | J Hazard Mater2011，192，： | 1 |
| 18 | Structural insights into the substrate specificity of Streptococcus pneumoniae β(1,3) galac- tosidase BgaC显示文摘 | Cheng W Wang L Jiang Y L | 2012 | Biol Chem J2012，287，22： | 1 |
| 19 | Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride显示文摘 | Lee C Y Peng W H Cheng H Y Chen F N Lai M T | 2006 | The American Journal of Chinese Medicine2006，34，3： | 1 |
| 20 | An efficient protocol for genomic DNA extraction from Citrus species显示文摘 | Cheng Y J Guo W W Yi H L Pang X M Deng X X | 2003 | Plant Molecular Biology Report2003，21，： | 1 |
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