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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 3 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 4 | Outcome After Hepatectomy for Multiple (Four or More) Colorectal Metastases in the Era of Effective Chemotherapy显示文摘 | Peter Kornprat MD William R. Jarnagin MD FACS Mithat Gonen PhD Ronald P. DeMatteo MD FACS Yuman Fong MD FACS Leslie H. Blumgart MD FACS FRCS Michael D'Angelica MD FACS | 2007 | Annals of Surgical Oncology2007，，3： | 3 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | CRISPR-Cas9基因编辑用于镰状细胞病和β地中海贫血的治疗显示文摘输血依赖性β地中海贫血(transfusion-dependent β-thalassemia,TDT)和镰状细胞病(sickle cell disease,SCD)是全球最常见的单基因疾病。SCD是血红蛋白的遗传缺陷,会导致红细胞变成月牙形。这些细胞可以溶解并阻塞小血管,从而剥夺人体组织中的氧气。该疾病可引起极度疼痛并损害肺、心脏、肾脏和肝脏。β地中海贫血是一种血液疾病,可减少血红蛋白的产生。 | 张四维(编译) Frangoul H Altshuler D Cappellini MD | 2021 | 国际老年医学杂志2021，42，5： | 3 |
| 7 | Hepatic and Extrahepatic Colorectal Metastases: When Resectable, Their Localization Does Not Matter, But Their Total Number Has a Prognostic Effect显示文摘 | Dominique Elias MD PhD Gabriel Liberale MD Déwi Vernerey MSc Marc Pocard MD PhD Michel Ducreux MD PhD Valérie Boige MD David Malka MD PhD Jean-Pierre Pignon MD PhD Philippe Lasser MD | 2005 | Annals of Surgical Oncology2005，，11： | 2 |
| 8 | The Use of Preoperative Endoscopic Tattooing in Laparoscopic Colorectal Cancer Surgery for Endoscopically Advanced Tumors: A Prospective Comparative Clinical Study显示文摘 | Ivan Arteaga-González MD Antonio Martín-Malagón MD Eudaldo M. López-Tomassetti Fernández MD Javier Arranz-Durán MD Adolfo Parra-Blanco MD David Nicolas-Perez MD Enrique Quintero-Carrión MD Hermogenes Díaz Luis MD Angel Carrillo-Pallares MD PhD | 2006 | World Journal of Surgery2006，，4： | 2 |
| 9 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 10 | Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV显示文摘High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion collisions.Redistribution of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic backgrounds.We report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR experiment.The correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5 | L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderón de la Barca Sánchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanád M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Nasim Md K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa S.Oh V.A.Okorokov B.S.Page R.Pak A.Pandav Y.Panebratsev B.Pawlik D.Pawlowska H.Pei C.Perkins L.Pinsky R.L.Pintér J.Pluta J.Porter M.Posik N.K.Pruthi M.Przybycien J.Putschke H.Qiu A.Quintero S.K.Radhakrishnan S.Ramachandran R.L.Ray R.Reed H.G.Ritter O.V.Rogachevskiy J.L.Romero L.Ruan J.Rusnak N.R.Sahoo H.Sako S.Salur J.Sandweiss S.Sato W.B.Schmidke N.Schmitz B.R.Schweid F.Seck J.Seger M.Sergeeva R.Seto P.Seyboth N.Shah E.Shahaliev P.V.Shanmuganathan M.Shao A.I.Sheikh F.Shen W.Q.Shen S.S.Shi Q.Y.Shou E.P.Sichtermann R.Sikora M.Simko J.Singh S.Singha N.Smirnov W.Solyst P.Sorensen H.M.Spinka B.Srivastava T.D.S.Stanislaus M.Stefaniak D.J.Stewart M.Strikhanov B.Stringfellow A.A.P.Suaide M.Sumbera B.Summa X.M.Sun X.Sun Y.Sun Y.Sun B.Surrow D.N.Svirida P.Szymanski A.H.Tang Z.Tang A.Taranenko T.Tarnowsky J.H.Thomas A.R.Timmins D.Tlusty M.Tokarev C.A.Tomkiel S.Trentalange R.E.Tribble P.Tribedy S.K.Tripathy O.D.Tsai Z.Tu T.Ullrich D.G.Underwood I.Upsal G.Van Buren J.Vanek A.N.Vasiliev I.Vassiliev F.Videbæk S.Vokal S.A.Voloshin F.Wang G.Wang J.S.Wang P.Wang Y.Wang Y.Wang Z.Wang J.C.Webb P.C.Weidenkaff L.Wen G.D.Westfall H.Wieman S.W.Wissink R.Witt Y.Wu Z.G.Xiao G.Xie W.Xie H.Xu N.Xu Q.H.Xu Y.F.Xu Y.Xu Z.Xu Z.Xu C.Yang Q.Yang S.Yang Y.Yang Z.Yang Z.Ye Z.Ye L.Yi K.Yip H.Zbroszczyk W.Zha C.Zhang D.Zhang S.Zhang S.Zhang X.P.Zhang Y.Zhang Y.Zhang Z.J.Zhang Z.Zhang Z.Zhang J.Zhao C.Zhong C.Zhou X.Zhu Z.Zhu M.Zurek M.Zyzak | 2020 | Chinese Physics C2020，44，10： | 2 |
| 11 | Liver Resection for Metastatic Colorectal Cancer in Patients with Concurrent Extrahepatic Disease: Results in 127 Patients Treated at a Single Center显示文摘 | Darren R. Carpizo PhD Chandrakanth Are MD William Jarnagin MD Ronald DeMatteo MD Yuman Fong MD Mithat G?nen PhD Leslie Blumgart MD Michael D'Angelica MD | 2009 | Annals of Surgical Oncology2009，，8： | 2 |
| 12 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 13 | Tramadol:pain relief by an opioid without depression of respiration显示文摘 | Vickers MD O'Flaherty D Szekely SM | 1992 | Anaesthesia1992，47，2： | 2 |
| 14 | Perihepatic Lymph Node Micrometastases Impact Outcome after Partial Hepatectomy for Colorectal Metastases显示文摘 | Joseph J. Bennett MD Carl R. Schmidt MD David S. Klimstra MD Stephen R. Grobmyer MD Nicole M. Ishill MS Michael D'Angelica MD Ronald P. DeMatteo MD Yuman Fong MD Leslie H. Blumgart MD William R. Jarnagin MD | 2008 | Annals of Surgical Oncology2008，，4： | 2 |
| 15 | Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘 | Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG | 2000 | JAMA2000，283，： | 1 |
| 16 | The management of acute thoracolumbar burst fractures with anterior corpectomy and Z - plate fixation 显示文摘 | Paul W McDonough MD Rick D | 2004 | Spine2004，29，： | 1 |
| 17 | Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome显示文摘 | Michael D Gershon MD | 2005 | J Clin Gastroenterol2005，39，53： | 1 |
| 18 | The use of a blade plate autogenous cancellous bone graft in the treatment of ununited fractures of the proximal humerus显示文摘 | Ring D McKee MD Perey BH | 2001 | Shoulder Elbow Surg2001，10，6： | 1 |
| 19 | Seven novel point mulations in the uroporphyrinogen decarboxylase (UROD) gene in patients with familial porphyria cutanea larda (f-PCT) 显示文摘 | Cappellini MD Martinez di Montemuros F Tavazzi D | 2001 | Hum Murat2001，17，4： | 1 |
| 20 | Systematic review of the impact of beta blockers on mortality and hospital admission in heart failure 显示文摘 | Shibata MC Flather MD Wang D | 2001 | Eur J Heart Fail2001，3，3： | 1 |
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