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| 1 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Efficient Bayesian inference for Gaussian copula regression models 显示文摘 | Pitt M Chan D Kohn R | 2006 | Biometrika2006，93，3： | 1 |
| 4 | A role for the scaffolding adapter Gab2 in breast cancer 显示文摘 | Bentires-Alj M Gil SG Chan R | 2006 | Nat Med2006，12，1： | 1 |
| 5 | Quantitative determination of sulfonamide in meat by liquid chromatography- electrospray mass spectrometry显示文摘 | FUH M R CHAN S A | 2001 | Talanta2001，55，6： | 1 |
| 6 | A multicenter trial of photorefractive keratectomy for residual myopia after previous ocular surgery显示文摘 | Maloney RK chan WK Steinert R Hersh P O' Connell M | 1995 | Ophthalmology1995，102，7： | 1 |
| 7 | Facies architecture and sequence stratigraphy of fine-grained lacustrine deltas along the eastern margin of Late Pleistocene Lake Bormevillie, northern Utah and southern Idaho 显示文摘 | Lemons D R Chan M A | 1999 | AAPG1999，83，4： | 1 |
| 8 | Replication ofavian and seasonal influenza viruses in human bronchus andlung显示文摘 | Chan R W Y Yuen K M Yu W C L | 2011 | Influenza Other Resp Viruses2011，5，： | 1 |
| 9 | RE-Tree:an efficient index structure for regular expressions显示文摘 | GAROFALAKIS M RASTOGI R | 2003 | International Journal on Very Large Data Bases2003，12，2： | 1 |
| 10 | Strang-type precondltloners for systems of LMF-based ODE codes显示文摘 | CHAN R NG M JIN Xiao-qing | 2001 | IMA J Numer Anal2001，21，2： | 1 |
| 11 | Determination of antibacterial reagents by liquid chromatography-elec- trospray-mass spectrometry显示文摘 | Fuh M R S Chan S A Wang H L | 2000 | Talanta2000，52，1： | 1 |
| 12 | Investigation of crystallinity effects on the surface of oxygen plasma treated low density polyethylene using X-ray photoelectron spectroscopy显示文摘 | Kwang S K Chang M R Chan S P | 2003 | Polymer2003，，44： | 1 |
| 13 | Group LAS~9 for Structural Break Time Series显示文摘 | Chan N H Yau C Y Zhang R M | 2014 | Journal of the American Statistical Association2014，109，506： | 1 |
| 14 | Preoperative ketamine improves postoperative analgesia after gynecologic laparoscopic surgery 显示文摘 | Kwok R F Lim J Chan M T | 2004 | Anesth Analg2004，98，4： | 1 |
| 15 | Terahertz imaging with compressed sensing and phase retrieval显示文摘 | W L Chan M Moravec R Baraniuk | 2008 | Optics Letters2008，33，9： | 1 |
| 16 | The role of Hex in heman- gioblast and hematopoietic development显示文摘 | Chan R J Hromas R Yoder M C | 2006 | Meth Mol Biol2006，330，： | 1 |
| 17 | Signaling by the TNF receptor superfamily and T cell homeostasis显示文摘 | Chan F K Siegel R M Lenardo M J | 2000 | Immunity2000，13，： | 1 |
| 18 | Diagenetic hematite and manganese oxides and fault-related fluid flow in Jurassic sandstones, southeastern Utah 显示文摘 | Chan M A Parry W T Bowman J R | 2000 | AAPG Bull2000，84，9： | 1 |
| 19 | A fast algorithm for deblurring models with neumann boundary conditions显示文摘 | Ng M K Chan R H Tang W | 1999 | SIAM Journal on Scientific Computing1999，21，3： | 1 |
| 20 | Sequential extraction and quantitative recovery of gliadins,glutenins,and other proteins from small samples of wheat flour显示文摘 | DUPONT F M CHAN R LOPEZ R | 2005 | J Agric Food Chem2005，53，5： | 1 |
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