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| 1 | Gastric cancer patients at high-risk of having synchronous cancer显示文摘瞄准:识别病人与一在胃的癌症病人之中有同步癌症高风险。方法:我们回顾地在国家癌症中心分析了未来的胃的癌症数据库,从 2000 年 12 月的朝鲜到 2004 年 12 月。有没有同步癌症的病人的同步癌症和那些的病人的 clinicopathological 特征被比较。Multivariate 分析被执行在胃的癌症病人为同步癌症的存在识别风险因素。结果:在数据库登记的 3291 个胃的癌症病人(3.4%) 中的 111 个有同步癌症。在这 111 个病人之中, 109 有单个同步癌症, 2 个病人有二同步癌症。同步癌症的最普通的形式是颜色表面的癌症(42 个病人, 37.2%) 由肺癌症列在后面(21 个病人, 18.6%) 。Multivariate 分析表明有区分的早胃的癌症的老病人有同步癌症的更高的可能性。结论:在胃的癌症病人的同步癌症不是很少发生的。医生应该试着在胃的癌症病人发现同步癌症,在特别与区分的早胃的癌症老。 | Jun Ho Lee Ja Seong Bae Keun Won Ryu Jong Seok Lee Sook Ryun Park Chan Gyoo Kim Myoung Cheorl Kook Il Ju Choi Young Woo Kim Jae-Gahb Park Jae-Moon Bae | 2006 | World Journal of Gastroenterology2006，12，16： | 15 |
| 2 | Comparison of hydrocolonic sonograpy accuracy in preoperative staging between colon and rectal cancer显示文摘To compare the accuracy of hydrocolonic sonography(HUS) in determining the depth of invasion (T stage) in colonand rectal cancer. | HyeWonChung JaeBockChung SeungWooPark SiYoungSong JinKyungKang Chan Il Park | 2004 | World Journal of Gastroenterology2004，10，8： | 9 |
| 3 | Individual having a parent with early-onset gastric cancer may need screening at younger age显示文摘AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with GC.METHODS: A total of 4282 patients diagnosed with GC at National Cancer Center Hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by questionnaire.RESULTS: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P < 0.001). However, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(< 50 years old), mean age at diagnosis was 47.7 ± 10.3 years for those with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier. | Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-Jeong Cho Bang Wool Eom Hong Man Yoon Jungnam Joo Keun Won Ryu Young-Woo Kim | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 4 | Effect of Nucleases on the Cellular Internalization of Fluorescent Labeled DNA-Functionalized Single-Walled Carbon Nanotubes显示文摘Nuclease effects on the cell internalization of single-walled carbon nanotubes(SWNTs)functionalized with fluorescent-labeled DNA in serum containing cell growth media were examined.When Cy3-labeled DNA-functionalized SWNT conjugates(Cy3DNA-SWNTs)were incubated with HeLa cells in a fatal bovine serum(FBS)medium,a high fl uorescence intensity was obtained from the cells,indicative for the high level inclusion of Cy3DNA-SWNTs.However,the fluorescence intensity was remarkably reduced if Cy3DNA-SWNTs were incubated with cells in the FBS-free medium.Further systematic control experiments revealed that Cy3 dye molecules were released from Cy3DNA-SWNT conjugates by nuclease,and the free Cy3 dyes penetrate into HeLa cell with high efficiency.Although the actual amounts of SWNTs internalized in the cells were almost identical for both cells incubated in the FBS-present and FBS-absent media according to the Raman measurements,one should be cautious to determine the degree of SWNT internalization based on the fl uorescence intensities especially when the coloring dye molecules were linked to oligonucleotides in nuclease containing media. | Hye Kyung Moon Chan Il Chang Dong-Ki Lee Hee Cheul Choi | 2008 | Nano Research2008，1，4： | 7 |
| 5 | Endoscopic submucosal dissection for metachronous tumor in the remnant stomach after distal gastrectomy显示文摘 | Jong Yeul Lee Il Ju Choi Soo-Jeong Cho Chan Gyoo Kim Myeong-Cherl Kook Jun Ho Lee Keun Won Ryu Young-Woo Kim | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 6 | Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study显示文摘AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients. | Eun Kyung Lee So Young Kim You Jin Lee Mi Hyang Kwak Hak Jin Kim Il Ju Choi Soo-Jeong Cho Young Woo Kim Jong Yeul Lee Chan Gyoo Kim Hong Man Yoon Bang Wool Eom Sun-Young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 7 | Robot-assisted total gastrectomy is comparable with laparoscopically assisted total gastrectomy for early gastric cancer显示文摘 | Hong Yoon Young-Woo Kim Jun Lee Keun Ryu Bang Eom Ji Park Il Choi Chan Kim Jong Lee Soo Cho Ji Rho | 2012 | Surgical Endoscopy2012，，5： | 2 |
| 8 | Endoscopic ultrasound and computed tomography in restaging and predicting prognosis after neoadjuvant chemotherapy in patients with locally advanced gastric cancer显示文摘 | Sook RyunPark Jong SeokLee Chan GyooKim Hark KyunKim Myeong‐CherlKook Young‐WooKim Keun WonRyu Jun HoLee Jae‐MoonBae Il JuChoi | 2008 | Cancer2008，，11： | 2 |
| 9 | Surgical Indication for Non-curative Endoscopic Resection in Early Gastric Cancer显示文摘 | Keun Won Ryu MD Il Ju Choi MD Young Woo Doh MD Myeong-Cherl Kook MD Chan Gyoo Kim MD Hyun-Jung Park RN Jun Ho Lee MD Jong-Seok Lee MD Jong Yeul Lee MD Young Woo Kim MD Jae-Moon Bae MD | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 10 | Clinical Application of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Progressive Hemifacial Atrophy (Parry-Romberg Disease) With Microfat Grafting Techniques Using 3-Dimensional Computed Tomography and 3-Dimensional Camera显示文摘 | Kyung Suk Koh Tae Suk Oh Hoon Kim In Wook Chung Kang Woo Lee Hyo Bo Lee Eun Jung Park Jae Seob Jung Il Seob Shin Jeong Chan Ra Jong Woo Choi | 2012 | Annals of Plastic Surgery2012，，3： | 2 |
| 11 | Covered versus uncovered self-expandable metallic stents for palliation of malignant pyloric obstruction in gastric cancer patients: a randomized, prospective study显示文摘 | Chan Gyoo Kim Il Ju Choi Jong Yeul Lee Soo-Jeong Cho Sook Ryun Park Jun Ho Lee Keun Won Ryu Young-Woo Kim Young Iee Park | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 12 | Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer显示文摘 | Hong-Gyun Wu Yung-Jue Bang Eun Kyung Choi Yong Chan Ahn Young Whan Kim Tae-Hwan Lim Cheolwon Suh Keunchil Park Charn Il Park | 2002 | International Journal of Radiation Oncology Biology Physics2002，，1： | 1 |
| 13 | Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hy- persensitivity to excitotoxicity显示文摘 | Kruman IL Culmsee C Chan SL | 2000 | J Neurosci2000，20，18： | 1 |
| 14 | Saccular damage in patients with idiopathic sudden sensorineural hearing loss without vertigo显示文摘 | Seok Min Hong Jae Yong Byun Chan Hum Park Jun Ho Lee Moon Suh Park Chang Il Cha | 2008 | Otolaryngology - Head and Neck Surgery2008，，4： | 1 |
| 15 | estimated prevalence of orthopaedic fractures in taiwan:cross-estimated study based on nation-wide insurance data显示文摘 | Yang NP Chan CL Yu IL | | 0，，12： | 1 |
| 16 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 17 | A New Suggestion for the Radiation Target Volume After a Subtotal Gastrectomy in Patients With Stomach Cancer显示文摘 | Heerim Nam Do Hoon Lim Sung Kim Won Ki Kang Tae Sung Sohn Jae Hyung Noh Yong Il Kim Chan Hyung Park Chul Keun Park Yong Chan Ahn Seung Jae Huh | 2008 | International Journal of Radiation Oncology Biology Physics2008，，2： | 1 |
| 18 | Risk Factors Associated with Gastric Cancer in Patients with a Duodenal Ulcer显示文摘 | Soo‐JeongCho Il JuChoi Chan GyooKim Myeong‐CherlKook Jong YeulLee Byung ChangKim Kum HeiRyu Su YounNam Young‐WooKim | 2010 | Helicobacter2010，，6： | 1 |
| 19 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 20 | Estimated prevalence of ortho- paedic fractures in Taiwan: a cross-sectional study based on nation- wide insurance data显示文摘 | Yang NP Chan CL Yu IL | 2010 | Injury2010，41，12： | 1 |
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