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| 1 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 2 | Bone morphogenetic protein 2 promotes transforming growth factor β3-induced chondrogenesis of human osteoarthritic synovium-derived stem cells显示文摘有更高的 chondrogenic 潜力的背景导出 Synovium 的干细胞(SDSC ) 为软骨新生作为房间来源正在吸引可观的注意。我们调查了骨头的效果形态基因的蛋白质(BMP-2 ) 2 在转变生长因素 beta3 (TGF-3 ) 以后导致了在一个小团文化系统从人的 osteoarthritic synovium 孤立的 SDSC 的 chondrogenesis。clonogenicity,干细胞标记表示和孤立的 SDSC 的多区别潜力被殖民地形成统一试金,流动 cytometry 并且包括分别地染色的茜素红 S,油红 O 和 alcian 蓝色的特定的染色决定的方法。SDSC 小团在与或没有 TGF-3 或 / 并且 BMP-2 中等的 chondrogenic 是有教养的。在白天 21 点,直径和小团的重量被测量。SDSC 的 Chondrogenic 区别被藏红染料 O 染色,骨胶原类型染色的 immunohistochemical, sulfated glycosaminoglycan (sGAG ) 合成和骨胶原类型, aggrecan, SOX9,连接蛋白质,骨胶原类型 X 和 BMP 受体的 mRNA 表示评估。在优化 culturing 密度(104/60 cm2 ) 下面孤立的结果房间显示出 clonogenicity 和多区别潜力。这些房间是积极的(99 ) 为 CD44, CD90, CD105 并且否定(10 ) 为 CD34 和 CD71。在包含 TGF-3 与或没有 BMP-2 的 chondrogenic 媒介区分到 chondrocytic 显型的 SDSC。细胞外的矩阵染色的藏红染料 O 是积极的,骨胶原类型的表示被检测。房间小团独自与 TGF-3 对待, BMP-2 在直径和重量是更大的,生产了更多的 sGAGs,并且表示了骨胶原类型和另外的 chondrogenic 标记的高水平,比有 TGF-3 的媒介,除了 COL10A1。结论 SDSC 能从人的 osteoarthritic synovium 被孤立。有 BMP-2 的补充显著地支持了在里面 SDSC 的 vitro TGF-3-induced chondrogenic 区别。 | RUI Yun-feng DU Lin WANG You WANG Yang LUI Pauline po-yee TANG Ting-ting CHAN Kai-ming DAI Ke-rong | 2010 | Chinese Medical Journal2010，，21： | 19 |
| 3 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 4 | Overexpression of the Suaeda salsa SsNHX1 gene confers enhanced salt and drought tolerance to transgenic Zea mays显示文摘Maize is one of the most important crops worldwide, but it suffers from salt stress when grown in saline-alkaline soil. There is therefore an urgent need to improve maize salt tolerance and crop yield. In this study, the SsNHX1 gene of Suaeda salsa, which encodes a vacuolar membrane Na^+/H^+ antiporter, was transformed into the maize inbred line 18-599 by Agrobacterium-mediated transformation. Transgenic maize plants overexpressing the SsNHX1 gene showed less growth retardation when treated with an increasing NaCl gradient of up to 1%, indicating enhanced salt tolerance. The improved salt tolerance of transgenic plants was also demonstrated by a significantly elevated seed germination rate(79%) and a reduction in seminal root length inhibition. Moreover, transgenic plants under salt stress exhibited less physiological damage. SsNHX1-overexpressing transgenic maize accumulated more Na^+ and K^+ than wild-type(WT) plants particularly in the leaves, resulting in a higher ratio of K^+/Na^+ in the leaves under salt stress. This result revealed that the improved salt tolerance of SsNHX1-overexpressing transgenic maize plants was likely attributed to SsNHX1-mediated localization of Na^+ to vacuoles and subsequent maintenance of the cytosolic ionic balance. In addition, SsNHX1 overexpression also improved the drought tolerance of the transgenic maize plants, as rehydrated transgenic plants were restored to normal growth while WT plants did not grow normally after dehydration treatment. Therefore, based on our engineering approach, SsNHX1 represents a promising candidate gene for improving the salt and drought tolerance of maize and other crops. | HUANG Ying ZHANG Xiao-xia LI Yi-hong DING Jian-zhou DU Han-mei ZHAO Zhuo ZHOU Li-na LIU Chan GAO Shi-bin CAO Mo-ju LU Yan-li ZHANG Su-zhi | 2018 | Journal of Integrative Agriculture2018，17，12： | 8 |
| 5 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 6 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 7 | Study on the adoption of Schwann Cell Phenotype by Bone Marrow Stromal Cells in vitro and in vivo显示文摘Objective To explore the possibilities of bone marrow stromal cells (MSCs) to adopt Schwann cell phenotype in vitro and in vivo in SD rats. Methods MSCs were obtained from tibia and femur bone marrow and cultured in culture flasks. Beta-mercaptoethanol followed by retinoic acid, forskolin, basic-FGF, PDGF and heregulin were added to induce differentiation of MSCs’. Schwann cell markers, p75, S-100 and GFAP were used to discriminate induced properties of MSCs’ by immunofluorescent staining. PKH-67-labelled MSCs were transplanted into the mechanically injured rat sciatic nerve, and laser confocal microscopy was performed to localize the PKH67 labelled MSCs in the injured sciatic nerve two weeks after the operation. Fluorescence PKH67 attenuation rule was evaluated by flow cytometry in vitro. Results MSCs changed morphologically into cells resembling primary cultured Schwann cells after their induction in vitro. In vivo, a large number of MSCs were cumulated within the layer of epineurium around the injured nerve and expressed Schwann cell markers, p75, S-100, and GFAP. Conclusion MSCs are able to support nerve fiber regeneration and re-myelination by taking on Schwann cell function, and can be potentially used as possible substitutable cells for artificial nerve conduits to promote nerve regeneration. | FU-QIANG ZHAO PEI-XUN ZHANG XIANG-JUN HE CHAN DU ZHONG-GUO FU DIAN-YING ZHANG BAO-GUO JIANG | 2005 | Biomedical and Environmental Sciences2005，18，5： | 4 |
| 8 | Tuneable red,green,and blue single-mode lasing in heterogeneously coupled organic spherical microcavities显示文摘Tuneable microlasers that span the full visible spectrum,particularly red,green,and blue(RGB)colors,are of crucial importance for various optical devices.However,RGB microlasers usually operate in multimode because the mode selection strategy cannot be applied to the entire visible spectrum simultaneously,which has severely restricted their applications in on-chip optical processing and communication.Here,an approach for the generation of tuneable multicolor single-mode lasers in heterogeneously coupled microresonators composed of distinct spherical microcavities is proposed.With each microcavity serving as both a whispering-gallery-mode(WGM)resonator and a modulator for the other microcavities,a single-mode laser has been achieved.The colors of the single-mode lasers can be freely designed by changing the optical gain in coupled cavities owing to the flexibility of the organic materials.Benefiting from the excellent compatibility,distinct color-emissive microspheres can be integrated to form a heterogeneously coupled system,where tuneable RGB single-mode lasing is realized owing to the capability for optical coupling between multiple resonators.Our findings provide a comprehensive understanding of the lasing modulation that might lead to innovation in structure designs for photonic integration. | Yuxiang Du Chang-Ling Zou Chunhuan Zhang Kang Wang Chan Qiao Jiannian Yao Yong Sheng Zhao | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 9 | Altered small-world,functional brain networks in patients with lower back pain显示文摘In this study, we aimed to investigate the functional network changes that occur in patients with lower back pain(LBP). We also investigated the link between LBP and the small-world properties of functional networks within the brain. Functional MRI(fMRI) was performed on 20 individuals with LBP and 17 age and gender-matched normal controls during the resting state. The severity of the pain in the individuals with LBP ranged from 5 to 8 on a 0–10 scale, with 0 indicating no pain. Network-based statistics were performed to investigate the differences between the brain networks of individuals with LBP and those of normal controls. Several small-world parameters of brain networks were calculated, including the clustering coefficient, characteristic path length, local efficiency, and global efficiency. These criteria reflect the overall network efficiency. The brain networks in the individuals with LBP due to herniation of a lumbar disc demonstrated a significantly longer characteristic path length as well as a lower clustering coefficient, global efficiency, and local efficiency compared to those in control subjects. We found that LBP patients tended to have unstable and inefficient brain networks when compared with healthy controls. In addition, LBP individuals showed significantly decreased functional connectivity in the anterior cingulate cortex, middle cingulate cortex, post cingulate cortex, inferior frontal gyrus, middle temporal gyrus, occipital gyrus, postcentral gyrus, precentral gyrus, supplementary motor area, thalamus, fusiform, caudate, and cerebellum. We believe that these regions may be involved in the pathophysiology of lower back pain. | Jing Liu Feng zhang Xiufen Liu Zhizheng Zhuo Juan Wei Minyi Du Queenie Chan Xiaoying Wang Dongxin Wang | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 10 | Building metallurgical bonding interfaces in an immiscible Mo/Cu system by irradiation damage alloying (IDA)显示文摘For the immiscible Mo/Cu system with a positive heat of mixing(△H_m > 0), building metallurgical bonding interfaces directly between immiscible Mo and Cu and preparing Mo/Cu laminar metal matrix composites(LMMCs) are very difficult. To solve the problem, a new alloying method for immiscible systems, which is named as irradiation damage alloying(IDA), is presented in this paper. The IDA primarily consists of three steps. Firstly, Mo is damaged by irradiation with multi-energy(186, 62 keV) Cu ion beams at a dose of 2 × 10^(17) ions/cm^2. Secondly, Cu layers are superimposed on the surfaces of the irradiation-damaged Mo to obtain Mo/Cu laminated specimens. Thirdly, the irradiation damage induces the diffusion alloying between Mo and Cu when the laminated specimens are annealed at 950℃ in a protective atmosphere.Through IDA, Mo/Cu LMMCs are prepared in this paper. The tensile tests carried out for the Mo/Cu LMMCs specimens show that the Mo/Cu interfaces constructed via IDA have high normal and shear strengths.Additionally, the microstructure of the Mo/Cu interface is characterized by High Resolution Transmission Electron Microscopy(HRTEM), X-ray diffraction(XRD) and Energy Dispersive X-ray(EDX) attached in HRTEM. The microscopic characterization results show that the expectant diffusion between Mo and Cu occurs through the irradiation damage during the process of IDA. Thus a Mo/Cu metallurgical bonding interface successfully forms. Moreover, the microscopic test results show that the Mo/Cu metallurgical interface is mainly constituted of crystalline phases with twisted and tangled lattices, and amorphous phase is not observed. Finally, based on the positron annihilation spectroscopy(PAS) and HRTEM results,the diffusion mechanism of IDA is discussed and determined to be vacancy assisted diffusion. | Jinlong Du Yuan Huang Chan Xiao Yongchang Liu | 2018 | Journal of Materials Science & Technology2018，34，4： | 4 |
| 11 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 12 | Hydrogel-based flexible materials for diabetes diagnosis,treatment,and management显示文摘Diabetes is a chronic metabolic disease characterized by high glucose concentration in blood.Conventional management of diabetes requires skin pricking and subcutaneous injection,causing physical pain and physiological issues to diabetic individuals.Hydrogels possess unique advantages such as lightweight,stretchability,biocompatibility,and biodegradability,offering the opportunities to be integrated as flexible devices for diabetes management.This review highlights the development of hydrogels as flexible materials for diabetes applications in glucose monitoring,insulin delivery,wound care,and cell transplantation in recent years.Challenges and prospects in the development of hydrogel-based flexible devices for personalized management of diabetes are discussed as well. | Jiang Song Yanni Zhang Siew Yin Chan Zhaoyi Du Yinjia Yan Tengjiao Wang Peng Li Wei Huang | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 13 | Neuronal differentiation of PC12 cells induced by sciatic nerve and optic nerve conditioned medium显示文摘以前的工作显示出的背景那根眼的神经和臀部的神经神经原上的有条件的中等举办神经营养的活动。为了如果眼的神经调节了媒介(厘米),发现,有一项类似的活动让 PC12 细胞区分同样臀部的神经厘米,我们在 vitro 系统在一样在眼的神经厘米探索了神经营养的活动并且在两个 conditions.Methods PC12 房间下面在眼、臀部的神经比较了 neurotrophin 表示层次被用来检验臀部的神经和眼的神经分泌的 neurotrophins 的效果。 RT-PCR 和即时 QPCR 证明臀部的神经和眼的神经包括神经生长因素( NGF )生产了 neurotrophins 的一个范围,大脑导出神经营养的因素( BDNF )和 neurotrophin-3 ( NT-3 ) .Results 神经突长出上的臀部的神经和眼的神经厘米的效果对 neurotrophins 的一个范围被测试,并且他们举办了不同 neuritogenic 活动。仅仅 NGF 和臀部的神经厘米举办了明显的 neuritogenic 活动,尽管在臀部的神经厘米的 NGF 的集中是很我们的实验显示出的 low.Conclusions 那臀部的神经厘米比眼的神经厘米在 PC12 房间上举办了一项更高神经营养的活动。这些结果建议那个外部神经系统(PNS ) 和中央神经系统(CNS ) 有 neurotrophin 的不同表示层次,它可以部分地解释改革 CNS 的能力的缺乏。 | DU Chan YANG De-mei ZHANG Pei-xun DENG Lei JIANG Bao-guo | 2010 | Chinese Medical Journal2010，，3： | 2 |
| 14 | S6B-2 Matrine Inhibits Itching by Lowering the Activity of Calcium Channel显示文摘Sophorae Flavescentis Radix(SFR)is a medicinal herb with many functions that are involved in anti-inflammation,antinociception,and anticancer.SFR is also used to treat a variety of itching diseases.Matrine(MT)is one of the main constituents in SFR and also has the effect of relieving itching,but the antipruritic mechanism is still unclear.Here,we investigated the effect of MT on antipruritus.In acute and chronic itch models,MT significantly inhibited the scratching behavior not only in acute itching induced by histamine(His),chloroquine(CQ)and compound 48/80 with a dose-depended manner,but also in the chronic pruritus models of Atopic dermatitis(AD)and Acetone-ether-water(AEW)in mice.Furthermore,MT can be detected in the blood after intraperitoneal injection(i.p.)and subcutaneous injection(s.c.).Finally,electrophysiological and calcium image results show that MT inhibits the excitatory synaptic transmission from dorsal root ganglion(DRG)to the dorsal horn of the spinal cord by suppressing presynaptic N-type calcium channels.Taken together,we believe that MT is a novel drug candidate in treating pruritus diseases,especially for histamine-independent and chronic pruritus,which might be attributed to inhibition of presynaptic N-type calcium channels. | GENG Xiao SHI Hao YE Fan DU Han QIAN Lin-nan GU Le-ying WU Guan-yi ZHU Chan YANG Yan WANG Chang-ming ZHOU Yuan YU Guang LIU Qin DONG Xin-zhong YU Lei 唐宗湘 | 2018 | 神经药理学报2018，8，4： | 2 |
| 15 | Analysis of a New Chaotic System显示文摘 | Qi Guoyan Chan Guanrong Du Shengzhi | 2005 | Physica A: Statistical Mechanics and Its Applications2005，352，24： | 1 |
| 16 | Enhanced space-time block coded systems by concatenating turbo product codes显示文摘 | DU Y G CHAN K T | 2004 | IEEE Communications Letters2004，8，6： | 1 |
| 17 | Comparison of Personal and Area Sampling Strategies in AssessingWorkers' Exposure to Vinyl Chloride Monomer 显示文摘 | Du CL Chan CC Wang JD | 1996 | Bull Environ Contam Toxicol1996，56，： | 1 |
| 18 | An empirical study on the critical success factors of small-to medium-sized projects in a South African mining company显示文摘 | Du Randt F J Van Waweran C C Chan K Y | 2014 | South African Journal of Industrial Engineering2014，25，2： | 1 |
| 19 | Residual capacity of corroded reinforcing bars 显示文摘 | Du Y G Clark L A Chan A H C | 2005 | Magazine of Concrete Research2005，57，3： | 1 |
| 20 | Residual capacity of corroded reinforcing bars 显示文摘 | Du Y G Clark L A Chan A H C | 2005 | Magazine of Concrete Research2005，57，3： | 1 |
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