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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Robust Array Beamforming with Sidelobe Control Using Support Vector Machines 显示文摘 | Cesar C G Ignacio S Javier V | 2007 | IEEE Trans on Signal Processing2007，55，2： | 1 |
| 3 | Robust array beam- forming wit h sidelobe cont rolusing support vector machines 显示文摘 | Cesar C G Ignacio S J avier V | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 4 | maternal and child undemutrition: Consequcnces for adult health and human capital 显示文摘 | CESAR G V LINDA A CAROLINE F | 2008 | The lancet2008，371，9607： | 1 |
| 5 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 6 | Comparatve evaluation of TEE,Conventional MRI and contrast enhance 3D breath-hold MRA in the post-operative follow-up of dissecting aneurysms显示文摘 | CESARE E D GIORDANO A V CERONE G | 2000 | Int J Card Imaging2000，16，： | 1 |
| 7 | Retinal vessel segmentation using the 2-D gabor wavelet and supervised classification显示文摘 | SOARES J V B LEANDRO J J G CESAR R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 8 | Buchwald-Hartwig Amination of(Hetero)Aryl Tosylates Using a Well-Defined NHeterocyclic Carbene/Palladium(11)Precatalyst显示文摘 | Zhang Y Lavigne G Cesar V | 2015 | J Org Chem2015，80，： | 1 |
| 9 | Reti-nal vessel segmentation using the 2-D gabor wavelet and su-pervised classification显示文摘 | SOARES J B V LEANDRO J J G CESAR R M | 2006 | Ieee Transactions on Medical Ima-ging2006，25，9： | 1 |
| 10 | Review:Basic biochemical mech-anisms behind the health benefits of polyphen- ols 显示文摘 | Cesar G Fraga Monica Galleano Sandra V Ve- rstraeten | 2010 | Molecular Aspects of Medicine2010，31，： | 1 |
| 11 | Robust array beamforming with sidelobe control using support vector machines显示文摘 | CESAR C G JAVIER V IGNACIO S | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 12 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar J | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 13 | Robust array beanfforming with side lobe control using support vector machines 显示文摘 | Cesar C G Javier V lgnacio S | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 14 | Retinal vessel segmentation using the 2 -D Gabor wavelet and supervised classification显示文摘 | SoaresJ V B LeandroJ J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 15 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification 显示文摘 | Joao V B Soares Jorge J G Leandro Roberto M Cesar J R | 2006 | IEEE Transactions on Medical Image2006，25，9： | 1 |
| 16 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 17 | Review:Basic biochemical me- chanisms behind the health benefits of polyph- enols 显示文摘 | Cesar G Fraga Monica Galleano Sandra V Ve- rstraeten | 2010 | Molecular Aspects of Medicine2010，31，： | 1 |
| 18 | Retinal vessel seg- mentation using the 2 - D Gabor wavelet and supervised classification显示文摘 | Joao V B S Jorge J G L Roberto M Cesar | 2006 | IEEE Transactions on Medical hnaging2006，25，9： | 1 |
| 19 | Robust Array Beamformingwith Sidelobe Control Using Support Vector Machines显示文摘 | Cesar C G Javier V Ignacio S | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 20 | Comparison of microinjection (Piezo-Electric) and cell fusion for nuclear transfer success with different cell types in cattle显示文摘 | Cesare G Irina L Ivan V | 2002 | Cloning and stem cell2002，4，3： | 1 |
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