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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 3 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 4 | Biogenic hydrogen sulfide emissions from selected Florida wetlands显示文摘 | CASTRO M A DIERBERG F E | 1987 | Water Air Soil Pollution1987，33，： | 1 |
| 5 | Experimental con- strains on Hercynian anatexis in the Iberian massif, Spain 显示文摘 | Castro A Corretg L G EI-Biad M | 2000 | Journal of Petrology2000，41，： | 1 |
| 6 | Electroelastic analysis of piezoelectric laminated structures显示文摘 | Sosa A Castro M A | 1993 | Applied Mechanics Review1993，46，： | 1 |
| 7 | Anhydrobiotic engineering of bacterial and mammalian cells: is intracellular trehalose sufficient显示文摘 | Tunnacliffe A Garcia de Castro A Manzanera M | 2001 | Cryobiology2001，43，2： | 1 |
| 8 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 9 | Synthesis and cytotoxicity of new aminoterpenylquinones显示文摘 | JOSE M DEL CORRAL M CASTRO M A | 2005 | Bioorganic & Medicinal Chemis- try2005，13，3： | 1 |
| 10 | Geometric morphometric analysis of the crown morphology of the lower first premolar of hominins, with special attention to Pleistocene Homo显示文摘 | G6mez-Robles A Martin6n-Torres M Bermfidez de Castro JM | 2008 | Journal of Human Evolution2008，55，： | 1 |
| 11 | A novel muta-tion in the growth and differentiation factor 9 (GDF9)gene is associated, in homozygosis, with increased ovula-tion rate in Santa Ines sheep 显示文摘 | Melo E O Silva B D M Castro E A | 2008 | Biology of Reproduction2008，78，141： | 1 |
| 12 | Mechanical properties of polyester mooring cables 显示文摘 | FERNANDES A C DEL VECCI-IIO C J M CASTRO G A V | 1999 | International Journal of Offshoreand Polar Engineering1999，9，3： | 1 |
| 13 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 14 | Reversible peripatum liver failure:a new per-epective on ahe diagnosis on 28 consecutive cases显示文摘 | Castro M A Fassett M J | 1999 | AmJ Obs-Gyn1999，181，2： | 1 |
| 15 | Pathogenic variation a- mong isolates of Pyrlcularia grisea infecting rice,wheat and grasses in Brazil显示文摘 | Prabhu A S Filippi M C Castro N | 1992 | Trop Pest Manage1992，38，： | 1 |
| 16 | Role of nitric oxide and bcl-2 fanily genes in the regulation of human endometrial apoptosis显示文摘 | CASTRO A JOHNSON MC ANIDO M | 2002 | Fertil Steril2002，78，3： | 1 |
| 17 | Scribe: a large-scale and decentralized application-level multicast infrastructure显示文摘 | CASTRO M DRUSHEL P KERMARREC A M | 2002 | Selected Areas in Communications2002，20，8： | 1 |
| 18 | Similar cell sur- face expression of beta2-microglobulin-free heavy chains by HLA-B27 subtypes differentially associated with ankylosing spondylitis 显示文摘 | VAZQUEZ M N LOPEZ D E CASTRO J A | 2005 | Arthritis Rheum2005，52，： | 1 |
| 19 | Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives 显示文摘 | Gordaliza M Garcia P A Castro M A | 2004 | Toxicon2004，44，4： | 1 |
| 20 | The electronic properties of graphene 显示文摘 | Castro Neto A H Guinea F Peres N M R | 2009 | Review of Mod- ern Physics2009，81，1： | 1 |
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