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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Controlling culture dynamics for the expansion of hematopoietic stem cells 显示文摘 | Madlambayan G J Rogers I Casper RF | 2001 | J Hematother Stem Cell Res2001，10，： | 1 |
| 3 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 4 | Human-robot interactions during the ro- bot-assisted urban search and rescue response at the World Trade Center 显示文摘 | Casper J Murphy RR | 2003 | Systems Man and Cybernetics Part B: Cybernet- ics IEEE Transactions on2003，33，3： | 1 |
| 5 | Transvaginal ultrasound in selective embryo reduction for muhiple pregnancy 显示文摘 | Gonen Y Blankier J Casper RP | 1990 | Obstet Gy necol1990，75，4： | 1 |
| 6 | HLA-G expression during preimplantation human embryo development 显示文摘 | Jurisicova A Casper RF MacLusky N J | 1996 | Proc Natl Acad Sci USA1996，93，1： | 1 |
| 7 | Deficiencies of antithrombin, protein C and protein S-practical experience in genetic analysis of a large patient cohort显示文摘 | Caspers M Pavlova A Driesen J | 2012 | Thromb Haemost2012，108，2： | 1 |
| 8 | Clinical implications of variations in anti‐infliximab antibody levels in patients with inflammatory bowel disease显示文摘 | Casper Steenholdt Magid Al‐khalaf J?rn Brynskov Klaus Bendtzen Ole ?. Thomsen Mark A. Ainsworth | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 9 | Characterization of abnormal one pronuclear human oocytes by morphology cytogenetics and in-situ hybridization显示文摘 | Balakier H Squire J Casper RF | 1993 | Hum Reprod1993，8，： | 1 |
| 10 | Work and family research in IO/OB : content analysis and review of the literature ( 1980-2002 ) 显示文摘 | Eby L T Casper W J Lockwood A | 2005 | Journal of Vocational Behavior2005，，66： | 1 |
| 11 | Combined in vivo confocal Raman spectroscopy and confoeal microscopy of human skin显示文摘 | CASPERS P J LUCASSEN G W PUPPELS G J | 2003 | Biophys J2003，85，1： | 1 |
| 12 | Experimental study of CFRP-prestressed high-strength concrete bridge beams 显示文摘 | Stoll F Saliba J E Casper L E | 2000 | Composite Structures2000，49，2： | 1 |
| 13 | Human-robot interactions during the ro- bot-assisted urban search and rescue response at the World Trade Center 显示文摘 | Casper J Murphy RR | 2003 | Systems Man and Cybernetics Part B: Cybernet- ics IEEE Transactions on2003，33，3： | 1 |
| 14 | Characterization of the first cell cycle in human zygotes:Implication for cryopreservation显示文摘 | Balakier H MacLusky N J Casper RF | 1993 | Fertil Steril1993，59，2： | 1 |
| 15 | Reso- nance Raman spectroscopy of red blood cells using near- infrared laser excitation显示文摘 | WOOD B R CASPERS P PUPPELS G J | 2007 | Analytical and Bioanalytical Chemistry2007，387，5： | 1 |
| 16 | Work-life benefits and job pursuitintentions : The role of anticipated organizational support 显示文摘 | Casper W J Buffardi L C | 2004 | Journal of Vocational Behavior2004，65，3： | 1 |
| 17 | The prognostic significance of acute phase proteins in patients with inoperable squamous cell carcinoma of the bronchus 显示文摘 | Caspers R J Pidcock N B Cooper E H | 1984 | Radiotherapy Oncology1984，2，2： | 1 |
| 18 | Evaluation of urea and dried whey in diets of cows during early lactation显示文摘 | CASPER D P SCHINGOETHE D J | 1986 | Journal of Dairy Science1986，69，： | 1 |
| 19 | Work and family research in IO/OB:Con- tent analysis and review of the literature (1980-2002) 显示文摘 | Eby L T Casper W J Lockwood A Bordeaux C BrinleyA | 2005 | Journal of vocational behavior2005，66，1： | 1 |
| 20 | Deficiencies of antithrombin, protein C and protein S-practical experience in genetic analysis of a large patient cohort 显示文摘 | Caspers M Pavlova A Driesen J | 2012 | Thromb Haemost2012，108，2： | 1 |
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