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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Dynamics of a multimodule variable geometry manipulator显示文摘 | CARON M MODI V J MISRA A K | 2002 | Acta Astronautica2002，50，10： | 2 |
| 3 | Combined models for glaze ice accretion and de-icing of current-carrying electrical eonduetors显示文摘 | Huneault M Langheit C Caron J | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 4 | Acromegaly and pregnancy: aretrospective multicenter study of 59 pregnancies in 46 women显示文摘 | Caron P Broussaud S Bertherat J | 2010 | JClin Endocrinol Metab2010，95，10： | 1 |
| 5 | Analysis of bacterial function by multi - colour fluorescence flow cytometry and single cell sorting 显示文摘 | Nebe V Caron G Stephens P J | 2000 | J Microbiol Methods2000，42，1： | 1 |
| 6 | Near wins prolong gambling on a video lottery terminal显示文摘 | Cote D Caron A Aubert J | 2003 | Journal of Gambling Studies2003，19，4： | 1 |
| 7 | Estimating Carbon Leakage and the Efficiency of Border Adjustments in General Equilibrium-DoesEctoral Aggregation Matter? 显示文摘 | Caron J | 2012 | Energy Economics2012，，34： | 1 |
| 8 | Beta-adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes 显示文摘 | Caron M G Lefkowitz R J | 1976 | Biochem Biophys Res Commun1976，68，2： | 1 |
| 9 | Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad显示文摘 | Nicand E Armstrong G L Enouf V Guthmann J P Guerin J P Caron M Nizou J Y Andraghetti R | 2005 | Med Virol2005，，7： | 1 |
| 10 | How to pack the genome for a safe trip显示文摘 | GOVIN J ROUSSEAUX S | 2005 | Prog Mol Subcell Biol2005，38，： | 1 |
| 11 | Charaterization of protistan assemblages in the Ross Sea, Antarctic by denaturing gradient gel electrophoresis显示文摘 | Gast R J Dennett M R Caron D A | 2004 | Applied and Environmental Mi crobiology2004，4，20： | 1 |
| 12 | Plant-induced changes in soil structure: processes and feedbacks显示文摘 | ANGERS D A CARON J | 1998 | Biogeochemistry1998，45，： | 1 |
| 13 | Establishment of male-specific epigenetic information显示文摘 | CARON C GOVIN J | 2005 | Gene2005，345，2： | 1 |
| 14 | Effect of the northern quahog Mercenaria mercenaria on the development of blooms of the brown tide alga Aureococcus anophagefferens 显示文摘 | CERRATO R CARON A LONSDALE J | 2004 | Mar Ecol Prog Ser2004，281，： | 1 |
| 15 | Transdifferentiation: a new concept in renal fibrogenesis显示文摘 | Strutz F Caron R Tomaszewski J | 1994 | J Am Soc N ephrol1994，5，： | 1 |
| 16 | Neuroblastoma:biology,prognosis,and treatment显示文摘 | Park J R Eggert A Caron H | 2008 | Pediatr Clin N Am2008，55，1： | 1 |
| 17 | Combined models for glaze ice accretion and de-icing of current-carrying electrical conductors显示文摘 | Huneault M Langheit C Caron J | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 18 | The role of histones in chromatin remodelling during mammalian spermiogenesis显示文摘 | Govin J Caron C Lestrat C | 2004 | Eur J Biochem2004，271，： | 1 |
| 19 | Nutrient Ac- quisition and Population Growth of a Mixotrophic Alga in Axenic and Bacterized Cultures 显示文摘 | SANDERS R W CARON D A DAVIDSON J M | 2001 | Microbial Ecology2001，42，4： | 1 |
| 20 | Catecholamine- induced subsensitivity of adelnylate cyclase associated with loss of beta-adrenergic receptor binding sites显示文摘 | Mukherjee C Caron M G Lefkowitz R J | 1975 | Proc Natl Acad Sci USA1975，72，5： | 1 |
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