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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Organ cheminescence:Noninvasive assay for oxidation radical reactions显示文摘 | Boveris A Cadenas D Reiter R | 1980 | Proc Natl Acad Sci USA1980，77，1： | 1 |
| 3 | Direct analysis of abscisic acid in crude plant extracts by liquid spray/tandem mass spectrometry 显示文摘 | GOMEZ- CADENAS A POZO O J GARCIA - AU- GUSTIN P | 2002 | Phytochem Anal2002，13，4： | 1 |
| 4 | The impact of disease activity on the quality of life,mental health status,and family dysfunction in colombian patients with rheumatoid arthritis显示文摘 | CADENA J VINACCIA S P(E)REZ A | 2003 | J Clin Rheumatol2003，9，3： | 1 |
| 5 | The Impact of Dis- ease Activity on the Quality of Life, Mental Health Status, And Family Dysfunction in Colombian Patients with Rheumatoid Arthriti显示文摘 | Cadena J Vinaccia S P6rez A | 2003 | J Clin Rheuma- tol2003，9，3： | 1 |
| 6 | Production of superoxide radicals and hydrogen peroxide by NADP-ubiquinone redutase and ubiquinolcytochrome reductase from beef-heart mitochodria显示文摘 | Cadenas E Boveris A Ragan C | 1977 | Arch Biochem Biophy1977，180，： | 1 |
| 7 | Redox and additon chemistry of quinoid compounds and its biological implications显示文摘 | Brunmark A Cadenas E | 1989 | Free Radic Biol Med1989，7，： | 1 |
| 8 | Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices 显示文摘 | Cadenas A Moro MA Hurtado O | 2000 | J Neurochem2000，74，5： | 1 |
| 9 | Treatment of shaft fractures in children with elastic titanium nails 显示文摘 | Mendoza-Balta R J Bello-Gonz lez A Rosas Cadena JL | 2009 | Acta Ortop Mex2009，23，5： | 1 |
| 10 | Biofuels as sustainable technologies:perspectives for less developed countries显示文摘 | Cadenas A Cabezudo S | 1998 | Technol Forecast SocialChange1998，58，1： | 1 |
| 11 | A methodology todetermine gaseous emissions in a composting plant 显示文摘 | CADENA E COLON J SANCHEZ A | 2009 | WasteManage2009，29，11： | 1 |
| 12 | 显示文摘 | Cadenas A F Perez Hbdar F J Maldonado Castilla C Moreno | 2005 | Langmuir2005，21，10： | 1 |
| 13 | Sensory analysis: relevance for prebiotic, probiotic, and synbiot- ic product development 显示文摘 | Cruz A G Cadena R S Walter E H M | 2010 | Comprehensive Reviews in Food Science and Food Safety2010，9，4： | 1 |
| 14 | A methodology to determine gaseous emissions in a composting plant显示文摘 | Cadena E Col6n J S6nchez A | 2009 | Waste Management2009，，29： | 1 |
| 15 | Environmental impact oftwo aerobic composting technologies using life cycle assessment显示文摘 | CADENA E C0L(3N J ARTOLA A | 2009 | International Journal of Life Cycle Assessment2009，14，5： | 1 |
| 16 | The impact of disease activity on the quality of life, mental health status, and family dysfunction in colombian patients with rheumatoid arthritis 显示文摘 | Cadena J Vinaccia S P6rez A | 2003 | J Clin Rheumatol2003，9，3： | 1 |
| 17 | Consumer perception of probiotic yogurt: performance of check all that apply (CATA), projective mapping, sorting and intensity scale 显示文摘 | A G Cruz R S Cadena W F Castro | 2013 | Food Research International2013，1，54： | 1 |
| 18 | Hormonal regulation of a cysteine proteinase gene, EPB- 1, in barley aleurone layers: cis- and trans- acting elements involved in the co-ordinated gene expression regulated by gibberellins and abscisic acid 显示文摘 | Cercos M Gomez- Cadenas A | 1999 | Plant J1999，19，： | 1 |
| 19 | Manufacture of low-sodium Minas fresh cheese: effect of the partial replacement of sodium chloride with potassium chloride 显示文摘 | Gomes A Cruz A Cadena R | 2011 | Journal of Dairy Science2011，94，6： | 1 |
| 20 | Tribological behavior of laser-textured NiCrBSi coatings显示文摘 | GARRIDO A H GONZALEZ R CADENAS M | 2011 | Wear2011，271，56： | 1 |
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