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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701显示文摘 | Rosita Cottone Mathias Büttner Berthilde Bauer Marco Henkel Eduard Hettich Hanns-Joachim Rziha | 1998 | Virus Research1998，，1： | 3 |
| 3 | Percutaneous vertebroplasty for osteolytic metastases and myeloma:effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up显示文摘 | Cotton A Dewatre F Cortet B | 1996 | Radiology1996，200，2： | 2 |
| 4 | Percutaneous vertebroplasty for osteolytic metastases and myloma; effects the percentage of lesion filling and leakage of methyl methacrylate at clinical follow-up显示文摘 | Dewate F Cortet b | 1996 | Radiology1996，200，： | 1 |
| 5 | Musculoskeletal System 显示文摘 | Cotton A Sauer B Blum-Moyse A | 2008 | Imag Proc Radiol Med Radiol2008，35，2： | 1 |
| 6 | Prehospital Intravenous Fluid Administration Is Associated With Higher Mortality in Trauma Patients: A National Trauma Data Bank Analysis显示文摘 | Haut E R Kalish B T Cotton B A | 2011 | Annals of Surgery2011，253，2： | 1 |
| 7 | Endoscopic sphincterotomy complications and their management: an attempt at consensus显示文摘 | COTTON P B LEHMAN G VENNES J | 1991 | Gastrointest Endosc1991，37，3： | 1 |
| 8 | Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical followup显示文摘 | Cotton h Dewatre F Cortet B | 1996 | Radiology1996，2000，： | 1 |
| 9 | Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow - up显示文摘 | Dewatre F Cortet B | 1996 | Radiology1996，200，： | 1 |
| 10 | Endoscopic sphincterotomy complications and their management:an attempt at consensus显示文摘 | Cotton P B Lehman G Vennes J | 1991 | Gastrointest Endosc1991，37，3： | 1 |
| 11 | Pernicious anemia,intragastric bacterial overgrowth, and possible consequences显示文摘 | Stockbruegger R W Cotton P B Menon G G | 1984 | Scand J Gastroenterol1984，19，3： | 1 |
| 12 | Mononuelear and Polynuclear Chemistry of Rhenium (liD:Its Pronounced Homophilieity 显示文摘 | COTTON F A CURTIS N F HARRIS C B et a l | 1964 | Science1964，145，： | 1 |
| 13 | Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model 显示文摘 | Jagannath S B Kantsevoy S V Vaughn C A Chung S S Cotton P B Gostout C J | 2005 | Gastrointest Endosc2005，61，： | 1 |
| 14 | Percutaneous vertebroplasty in the treatment of osteoporotic verte- bral compression fractures :an open prospective study 显示文摘 | Cortet B Cotton A Boutry R | 1999 | J Rheum1999，26，12： | 1 |
| 15 | Analytical Expressions of Capsize Boundary for a Ship with Roll Bias in Beam Waves 显示文摘 | Spyrou K J Cotton B Gurd B | 2002 | Journal of Ship Research2002，，46： | 1 |
| 16 | Endoscopic sphincterotomy complication and their management : an attempt at consensus 显示文摘 | Cotton P B Lehman G Vennes J | 1991 | Gastrointest Endosc1991，37，： | 1 |
| 17 | Placenta accreta:changing clinical aspects and outcome显示文摘 | Read J A Cotton D B Miler F C | 1980 | Obstet Gyuecol1980，56，1： | 1 |
| 18 | Percutaneous vertebroplasty:state of the art显示文摘 | Cotton A Boutry N Cortet B | 1998 | Radiographics1998，2，： | 1 |
| 19 | Percutaneous vertebroplasty state of the art显示文摘 | Cotton A Boutry N Cortet B | 1998 | Radiographics1998，18，： | 1 |
| 20 | Massive transfusion protocols for patients with substantial hemorrhage显示文摘 | YOUNG P P COTTON B A GOODNOUGH L T | 2011 | Transfus Med Rev2011，25，： | 1 |
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