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| 1 | Role of liver transplantation in the management of hepatoblastoma in the pediatric population显示文摘Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional 'exception' points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras. | Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana John A Goss | 2014 | World Journal of Transplantation2014,4,4: | 23 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008,14,28: | 7 |
| 3 | Percutaneous vertebroplasty for osteolytic metastases and myeloma:effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up显示文摘 | Cotton A Dewatre F Cortet B | 1996 | Radiology1996,200,2: | 2 |
| 4 | Percutaneous vertebroplasty for osteolytic metastases and myloma; effects the percentage of lesion filling and leakage of methyl methacrylate at clinical follow-up显示文摘 | Dewate F Cortet b | 1996 | Radiology1996,200,: | 1 |
| 5 | RAMS 2001 : Current status and future directions 显示文摘 | Cotton W R R A Pielke R L Qalko | 2002 | Meteor Atmos Phys2002,82,: | 1 |
| 6 | Musculoskeletal System 显示文摘 | Cotton A Sauer B Blum-Moyse A | 2008 | Imag Proc Radiol Med Radiol2008,35,2: | 1 |
| 7 | Prehospital Intravenous Fluid Administration Is Associated With Higher Mortality in Trauma Patients: A National Trauma Data Bank Analysis显示文摘 | Haut E R Kalish B T Cotton B A | 2011 | Annals of Surgery2011,253,2: | 1 |
| 8 | Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow - up显示文摘 | Dewatre F Cortet B | 1996 | Radiology1996,200,: | 1 |
| 9 | Further Study of the Linear Trinickel(II)Complex of Dipyridylamide显示文摘 | CLERAC R COTTON F A DUNBAR K R | 1999 | Inorg Chem1999,38,: | 1 |
| 10 | Lin- ear trichromium complexes with direct Cr to Cr contacts: 2 : Compounds with Cr3 (dipyridylamide) 4^3+cores 显示文摘 | CLERAC R COTTON F A DANIELS L M | 2000 | Inorg Chem2000,39,: | 1 |
| 11 | Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients显示文摘 | Cottone S Vadalà A Vella MC | 1998 | J Hum Hypertens1998,12,6: | 1 |
| 12 | Acta Crystallogr显示文摘 | Bennett MJ Cotton F A Weaver D L | 1967 | 23: 788-7961967,23,: | 1 |
| 13 | Regulation of synaptic strength and AMPA receptor subunit composition by PICK1 显示文摘 | Terashima A Cotton L Dev KK | 2004 | J Neurosci2004,24,: | 1 |
| 14 | Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease显示文摘 | Cottone M Kohn A Daperno M | 2011 | Clin Gastroenterol Hepatol2011,9,1: | 1 |
| 15 | Mononuelear and Polynuclear Chemistry of Rhenium (liD:Its Pronounced Homophilieity 显示文摘 | COTTON F A CURTIS N F HARRIS C B et a l | 1964 | Science1964,145,: | 1 |
| 16 | Experimental and theoretical studies of the copper(I) and silver(I) dinuclear N,N'-di-p-tolylformamidinato complexes显示文摘 | Cotton F A Feng X Matusz M | 1988 | J Am Chem Soc1988,110,21: | 1 |
| 17 | A Variant of the Low-Renolds-Number Two-Equation Turbulence Model Applied to Variable Property Mixed Convection Flows显示文摘 | Cotton M A Kirwin P J | 1995 | Heat and Fluid Flow1995,16,6: | 1 |
| 18 | Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model 显示文摘 | Jagannath S B Kantsevoy S V Vaughn C A Chung S S Cotton P B Gostout C J | 2005 | Gastrointest Endosc2005,61,: | 1 |
| 19 | Changes of Plasma endothelin and growth factor levels and of left ventricular mass, after chronic ATl-receptor blockade in human hypertension显示文摘 | Cottone S Vadala A Vella ML | 1998 | Am J Hypertens1998,11,: | 1 |
| 20 | Percutaneous vertebroplasty in the treatment of osteoporotic verte- bral compression fractures :an open prospective study 显示文摘 | Cortet B Cotton A Boutry R | 1999 | J Rheum1999,26,12: | 1 |