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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 3 | Transient liquid phase diffusion bonding A1-6061 using nano-dispersed Ni coatings 显示文摘 | COOKE K O KHAN T I OLIVER G D | 2011 | Materials and Design2011，33，： | 1 |
| 4 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 5 | The long term proghostic significance of oestrogen receptor analysis in early carcinoma of the breast显示文摘 | Winstanley J Cooke T George W D | 1991 | Br J Cancer1991，64，1： | 1 |
| 6 | Chromosome 17aneu- somy is associated with poor prognostic factors in invasive breast carcinomal 显示文摘 | Watters A D Going J J Cooke T G | 2003 | Breast Cancer Res Treat2003，77，2： | 1 |
| 7 | Effect of clot removal on cerebrovascular contraction after subarachnoid hemorrhage in the monkey: pharmacological study显示文摘 | TSUJI T COOK D A | 1996 | Heart Vessels1996，11，2： | 1 |
| 8 | Water balance of a tropical woodland ecosystem, Northern Australia: a combination of micro-meteorological, soil physical and groundwater chemical approaches 显示文摘 | COOK P G HATrON T J PIDSLEY D etal | 1998 | J Hydrol1998，，210： | 1 |
| 9 | Production of the alkaloid swainsonine by a fungal endosymbiont of the ascomycete order chaetothyriales in the host Ipomoea carnea显示文摘 | COOK D BEAULIEU W T MOTT I W | 2013 | Journal of Agricultural and Food Chemistry2013，61，16： | 1 |
| 10 | Problem-based learning: its role in undergraduate surgical education 显示文摘 | Chang G Cook D Maguire T | 1995 | Can J Surg1995，38，1： | 1 |
| 11 | Effects of chronic inhibition of GABA synthesis on attention and impulse control显示文摘 | PAINE T A COOKE E K LOWES D C | 2015 | Pharmacol Biochem Behav2015，135，： | 1 |
| 12 | The Oxford classification of IgA nephropathy : rationale, clinicopathologieal correlations, and classification显示文摘 | Cattran D C Coppo R Cook H T | 2009 | Kidney Int2009，76，5： | 1 |
| 13 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 14 | Improving results of open arch replacement 显示文摘 | SUNDT T M 3rd ORSZULAK T A COOK D J | 2008 | Ann Thorac Surg2008，86，8： | 1 |
| 15 | A preliminary investigation and evaluation of the thallium environmental impacts of the unmined Xiangquan thallium-only deposit in Hexian, China显示文摘 | Zhou T F Fan Y Yuan F Cooke D Zhang X Li L J | 2008 | Environ Geol2008，54，1： | 1 |
| 16 | Weathering of the balustrade on St Paul's Cathedral, London显示文摘 | SHARP A D TRUDGILL S T COOKE R U | 1982 | Earth Surface Processes and Landforms1982，7，4： | 1 |
| 17 | Detection of turkey rhinotracheitis virus in turkeys using the polymerase chain reac tion显示文摘 | Jing L Cook J K A Brown T D K | 1993 | Avian Pathol1993，22，4： | 1 |
| 18 | Solid Elements with Rotational Degrees of Freedom显示文摘 | YUNUS S M PAWLAK T P COOK R D | 1991 | International Journal for Numerical Methods in Engineering1991，31，： | 1 |
| 19 | Requirement of MIP - 1 alpha for an inflammatory response to viral infection 显示文摘 | COOK D N BECK M A COFFMAN T M | 1995 | Science1995，269，5230： | 1 |
| 20 | Problem-based learning: its role in undergraduate surgical education显示文摘 | Chang G Cook D Maguire T | 1995 | Can J Surg1995，38，1： | 1 |
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