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| 1 | Cancer-related inflammation and treatment effectiveness显示文摘 | Connie I Diakos Kellie A Charles Donald C McMillan Stephen J Clarke | 2014 | Lancet Oncology2014，，： | 3 |
| 2 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 3 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 4 | Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer显示文摘 | Connie PM Duong Jennifer A Westwood Linda J Berry Phillip K Darcy Michael H Kershaw | 2011 | Immunotherapy2011，，1： | 1 |
| 5 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 6 | Reservoir imaging using low frequencies of seismic reflections显示文摘 | GOLOSHUBIN G M CONNIE V A KORNEEV V A | 2006 | The Leading Edge2006，25，5： | 1 |
| 7 | Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy☆显示文摘 | Robert L Giuntoli Daniel S Metzinger Connie S DiMarco Stephen S Cha Jeff A Sloan Gary L Keeney Bobbie S Gostout | 2003 | Gynecologic Oncology2003，，： | 1 |
| 8 | Touch-less palm print biometrics: Novel design and implementation 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2008 | Image and Vision Computing2008，26，12： | 1 |
| 9 | Oral car in the adult intensive care unit显示文摘 | Julie A Fitch Cindy L Munro Connie A Glass | 1999 | Am J Crit Care1999，8，5： | 1 |
| 10 | The emergence of West Nile virus during a large outbreak in Illinois in2002显示文摘 | Gregory DH Connie A Cart L | 2005 | Am J Trop Med Hyg2005，72，： | 1 |
| 11 | Monitoring temporary immunodepression by flow cy- tometric measurement of monocytic HLA-DR expres- sion: a multicenter standardized study显示文摘 | Wolf-Dietrich DScke Conny HSflich Kenneth A et aI | 2005 | Clinical Chem- istry2005，51，： | 1 |
| 12 | Decreased hypothalamic gonadotropin-releasing hormone secreation in malemara runners显示文摘 | connie M Barkan A Lanpanan R M | | 0，，： | 1 |
| 13 | Personal recognition using multi-angles gait sequences显示文摘 | TEE Connie KAH O G M BENG J T A | 2011 | Communications in Computer and Information Science2011，189，2： | 1 |
| 14 | Food packaging and bisphenol A and bis (2-Ethyhexyl) phthalate exposure:findings from a dietary intervention显示文摘 | Rudel Ruthann A Gray Janet M Engel Connie L | | 0，，07： | 1 |
| 15 | Nondigestible oligo- saecharides inereaseealcium absorption and supperess bone re- sorption in ovariectomizedrata显示文摘 | Tasleem A Z Connie M W Yong D Z | 2004 | Nutr2004，134，： | 1 |
| 16 | An automated palmprint recognition system显示文摘 | Connie T Jin A T B Ong M G K | 2005 | Image and Vision Computing2005，23，5： | 1 |
| 17 | A contact- less biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representa- tion2012，23，7： | 1 |
| 18 | The isotopic characterization of methane, non-methane hydrocarbons and formaldehyde in the troposphere 显示文摘 | CONNY J M CURRIE L A | 1996 | Atmos Environ1996，30，4： | 1 |
| 19 | Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo显示文摘AIM:To generate an adenoviral vector specifically targeting the EphA2 receptor(EphA2R) highly expressed on pancreatic cancer cells in vivo.METHODS:YSA,a small peptide ligand that binds the EphA2R with high affinity,was inserted into the HI loop of the adenovirus serotype 5 fiber knob.To further increase the specificity of this vector,binding sites for native adenoviral receptors,the coxsackie and adenovirus receptor(CAR) and integrin,were ablated from the viral capsid.The ablated retargeted adenoviral vector was produced on 293T cells.Specifi c targeting of this novel adenoviral vector to pancreatic cancer was investigated on established human pancreatic cancer cell lines.Upon demonstrating specifi c in vitro targeting,in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.RESULTS:Ablation of native cellular binding sites reduced adenoviral transduction at least 100-fold.Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor.YSA-mediated transduction was inhibited by addition of synthetic YSA peptide.The transduction specificity of the ablated retargeted vector towards human pancreatic cancer cells was enhanced almost 10-fold in vitro.In a subsequent in vivo study in a nude(nu/nu) mouse model however,no increased adenoviral targeting to subcutaneously growing human pancreas cancer nodules was seen upon injection into the tail vein,nor upon injection into the peritoneum.CONCLUSION:Targeting the EphA2 receptor increases specificity of adenoviral transduction of human pancreatic cancer cells in vitro but fails to enhance pancreatic cancer transduction in vivo. | Michael A van Geer Conny T Bakker Naoya Koizumi Hiroyuki Mizuguchi John G Wesseling Ronald PJ Oude Elferink Piter J Bosma | 2009 | World Journal of Gastroenterology2009，15，22： | 1 |
| 20 | Hybridization and genetic variation in Danish populations of European crabapple ( Malus sylvestris ) 显示文摘 | Anders S L Conny B A Ditte C O | 2006 | Tree Genetics & Ge- nomes2006，2，： | 1 |
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