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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Self-cleaning test of doped TiO2-coated glass plates under solar exposure显示文摘 | Jorge M V Claudio F R Jorge R O | 2009 | Industrial & Engineering Chemistry Research2009，48，： | 1 |
| 3 | Global attractors for a semilinear hyperbolic equation in viscoelasticity显示文摘 | Claudio G Munoz J E Pata V | 2001 | J Math Anal Appl2001，260，1： | 1 |
| 4 | An application of a multi-objective tabu search algorithm to a bicriteria flowshop problem 显示文摘 | Armentano V A Claudio J E | 2004 | Journal of Heuristics2004，10，5： | 1 |
| 5 | Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells显示文摘 | Frncesco V Stefano M Claudio C Claudio G | 1998 | Alcolol1998，15，： | 1 |
| 6 | Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil 显示文摘 | Paola B Claudio G Marco V | 2007 | Atherosclerosis2007，190，： | 1 |
| 7 | Procalcitonin in acute car- diac patients显示文摘 | Claudio P Chiara L Serafina V | 2011 | Intern Emerg Med2011，6，3： | 1 |
| 8 | High prevalence of Activatied Intraepithelial Cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinoma with microsatellite instability显示文摘 | Riccardo D Alessandra V Claudio D | 1999 | Am J Path1999，154，： | 1 |
| 9 | Genetics and electrophoretic karyotyping of wild-type and astaxanthin mutant strains of Phaffia rhodozyma显示文摘 | Víctor Cifuentes Germán Hermosilla Claudio Martínez Ruben León Guido Pincheira Antonio Jiménez | 1997 | Antonie van Leeuwenhoek1997，，2： | 1 |
| 10 | Plasticizers infant nutrition and reproductive health 显示文摘 | Giuseppe L Claudio D F Alberto V | 2004 | Reproductive Toxicology2004，19，1： | 1 |
| 11 | Polyamines effect on i homeostasis and contractility in isolated rat ventricular cardiomyocytes显示文摘 | Carlo V Claudio F Flavio F | 1994 | Am J Physiol1994，267，36： | 1 |
| 12 | Antioxidant capacities,carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio D V Giulia G Luigi M Annunziata C Alberto R | | 0，，： | 1 |
| 13 | Streamwise-travelling waves of spanwise wall velocity for turbulent drag reduction显示文摘 | Maurizio Q Pierre R Claudio V | 2009 | Journal of Fluid Mechanics2009，627，： | 1 |
| 14 | High prevalence of activatied intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinoma with microsatellite instability显示文摘 | Riccardo D Alessandra V Claudio D | 1999 | Am J Pathol1999，154，： | 1 |
| 15 | Free radical-scavenging properties of olive oil polyphenols显示文摘 | FRANCESCO V GIORGIO B CLAUDIO G | 1998 | Biochemical and Biophysical Research Communications1998，24，1： | 1 |
| 16 | Heterogeneous and homogeneous catalytic ozonation of benzothiazole promoted by activated carbon:Kinetic approach显示文摘 | Héctor V Claudio A Z | 2006 | Chemosphere2006，65，： | 1 |
| 17 | The Effects of Innovation on Vertical Structure: Perspectives on Transaction Costs and Competences 显示文摘 | CLAUDIO W FRANCISCO M V | 2008 | The Academy of Management Review Archive2008，7，3： | 1 |
| 18 | Soil Conditioning of Sand for EPB Applications: A Laboratory Research显示文摘 | RAFFAELE V CLAUDIO O DANIELE P | 2007 | Tunneling and Underground Space Technology2007，23，3： | 1 |
| 19 | 显示文摘 | Jorge M V Claudio F R Sergio C | 2007 | Material Characterization2007，58，： | 1 |
| 20 | Vitamins and organic minerals supplementation and its effect upon the immunocompetence of broilers submitted to heat stress显示文摘 | Lilian K V Claudio W C Christine L | 2008 | Rev Bras Zool2008，37，4： | 1 |
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