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| 1 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma显示文摘 | O. Farges J. M. Regimbeau D. Fuks Y. P. Le Treut D. Cherqui P. Bachellier J. Y. Mabrut M. Adham F. R. Pruvot J. F. Gigot | 2012 | Br J Surg2012，，2： | 2 |
| 4 | Liver Resection for Transplantable Hepatocellular Carcinoma: Long-Term Survival and Role of Secondary Liver Transplantation显示文摘 | Daniel Cherqui Alexis Laurent Nicolas Mocellin Claude Tayar Alain Luciani Jeanne Tran Van Nhieu Thomas Decaens Monika Hurtova Riccardo Memeo Ariane Mallat Christophe Duvoux | 2009 | Annals of Surgery2009，，5： | 2 |
| 5 | Hepatic resection for hepatocellular carcinoma in patients with C hild– P ugh’s A cirrhosis: is clinical evidence of portal hypertension a contraindication?显示文摘 | Roberto Santambrogio Michael D. Kluger Mara Costa Andrea Belli Matteo Barabino Alexis Laurent Enrico Opocher Daniel Azoulay Daniel Cherqui | 2012 | HPB2012，，1： | 2 |
| 6 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O’Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 7 | Hepatic Artery Ligation for Arterial Rupture Following Liver Transplantation: A Reasonable Option显示文摘 | E. Boleslawski A. F. Bouras S. Truant G. Liddo A. Herrero B. Badic M. Audet M. Altieri A. Laurent N. Declerck F. Navarro C. Létoublon P. Wolf L. Chiche D. Cherqui F. R. Pruvot | 2013 | American Journal of Transplantation2013，，4： | 2 |
| 8 | Laparoscopic liver resection: a systematic review显示文摘 | Luca Viganò Claude Tayar Alexis Laurent Daniel Cherqui | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
| 9 | Laparoscopic resection of hepatocellular carcinoma: a F rench survey in 351 patients显示文摘 | Olivier Soubrane Claire Goumard Alexis Laurent Hadrien Tranchart Stéphanie Truant Brice Gayet Chadi Salloum Guillaume Luc Safi Dokmak Tullio Piardi Daniel Cherqui Ibrahim Dagher Emmanuel Boleslawski Eric Vibert Antonio Sa Cunha Jacques Belghiti Patrick Pe | 2014 | HPB2014，，4： | 2 |
| 10 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O'Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 11 | The international position on Laparoscopic liver surgery : the Louisville Statement,2008 显示文摘 | Buell JF Cherqui D Geller DA | 2009 | Ann Surg2009，250，5： | 1 |
| 12 | Randomized trial of choledochocholedochostomy with or without a T tube in orthotopic liver transplantation显示文摘 | Scatton O Meunier B Cherqui D | 2001 | Ann Surg2001，233，： | 1 |
| 13 | Major liver resection for carcinoma in jaundiced patients without biliary drainage显示文摘 | Cherqui D Benoist S Malassagne B | 2000 | Arch Surg2000，1350，： | 1 |
| 14 | Laparoscopic living donor hepatectomy for liver transplantation in children 显示文摘 | Cherqui D Soubranc O Husson E | 2002 | Lancet2002，359，9304： | 1 |
| 15 | Laparoscopic Liver Resection for Peripheral Hepatocellular Carcinoma in Patients With Chronic Liver Disease: Midterm Results and Perspectives显示文摘 | Daniel Cherqui Alexis Laurent Claude Tayar Stephen Chang Jeanne Tran Van Nhieu Jér?me Loriau Mehdi Karoui Christophe Duvoux Daniel Dhumeaux Pierre-Louis Fagniez | 2006 | Annals of Surgery2006，，4： | 1 |
| 16 | Laparoscopic versus open left lateral hepatic lobectomy:a case-control study显示文摘 | Lesurtel M Cherqui D Laurent A | 2003 | J Am Coil Surg2003，196，2： | 1 |
| 17 | Laparoscopic living donor hepatectomy for liver transplantation in children显示文摘 | Cherqui D Soubrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
| 18 | Randomized trial of choledochostomy with or without a T tube in orthotopic liver transplantation显示文摘 | Scatton O Meunier B Cherqui D | 2001 | Ann Surg2001，233，3： | 1 |
| 19 | Laparoscopic living donor hepatectomy for liver transplantation in children显示文摘 | Sonbrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
| 20 | Laparoscopic living donor hepatectomy for liver transplantation in children 显示文摘 | Cherqui D Soubrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
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