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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 3 | 颈动脉硬化进展与病程≥10年的高血压治疗之间的关系:多种族动脉粥样硬化研究显示文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg(1mm Hg=0.133kPa)或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访(9.4±0.5)年后测定右颈总动脉的杨氏弹性模量和扩张系数。 | Gepner AD Tedla Y Colangelo LA Tattersall MC Korcarz CE Kaufman JD Liu K Burke GL Shea S Greenland P Stein JH 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | 无心血管病者尿钠排泄、血压与未来心血管病及死亡风险显示文摘高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄56.3岁,44.7%为男性)尿电解质与血压的数据。采用Kawasaki公式估算每日尿钠排泄量。研究者分析基线无心血管病、治疗的高血压或糖尿病者(n=322624)钠排泄与血压的关系,并评估钠排泄与致死性及非致死性心血管病、心力衰竭及死亡发生率的关系。 | Welsh CE Welsh P Jhund P Delles C Celis-Morales C Lewsey JD Gray S Lyall D Iliodromiti S Gill JMR Sattar N Mark PB 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 5 | Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold 显示文摘 | Semino CE Kasahara J Hayashi Y Zhang S | 2004 | Tissue Eng2004，10，： | 1 |
| 6 | Cutaneous head anti neck squamous celt carcinoma metastatic to parotid and cervical lymph nodes 显示文摘 | Veness M J Porceddu S Pahne CE | 2007 | Head Neck2007，29，7： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Regulatory T cells inhibit stable contacts between CD4^+ T cells and dendritic cells in vivo 显示文摘 | Tadokoro CE Shakhar G Shen S | 2006 | J Exp Med2006，203，3： | 1 |
| 9 | Inhibition of vascular endotheli- al growth factor/vascular permeability factor action blocks estrogen - in- duced uterine edema and implantation in rodents 显示文摘 | Rockwell LC Pillai S Olson CE | 2002 | Biology of Re- production2002，67，： | 1 |
| 10 | Case report: isolated neurofibrosarcoma of the liver: US,CT and MR findings显示文摘 | Neumaier CE Onetto F Delucchi S | 1997 | Clin Radiol1997，52，4： | 1 |
| 11 | Usefulness of echocardiographic evidence of pericardial effusion and mitral regurgitation during the acute stage in predicting development of coronary arterial aneurysms in the late stage of Kawasaki disease显示文摘 | Gidding SS Duffy CE Pajcic S | 1987 | Am J Cardiol1987，60，1： | 1 |
| 12 | Age-dependent changes in heparan sulfate in human Bruch' s membrane: implications for age- related macular degeneration 显示文摘 | KEENAN TD PICKFORD CE HOLLEY R J CLARK S J LIN W DOWSEY AW | 2014 | Invest Ophthalmol Vis Sci2014，55，8： | 1 |
| 13 | Carbohydrateinduced memory impairment in adults with type 2 diabetes显示文摘 | Greenwood CE Kaplan RJ Hebblethwaite S | 2003 | Diabetes Care2003，26，7： | 1 |
| 14 | Functional differentiation of hepatocyteqike spheroid structures from putative liver progenitor cells in three dimensional peptide scaffolds 显示文摘 | Semino CE Merok JR Crane GG Panagiotakos G Zhang S | 2003 | Differentiation2003，71，： | 1 |
| 15 | Evidence for a susceptibility locus for schizophrenia on 6pter-p22 显示文摘 | Wang S Sun CE Walczak CA | 1995 | Nature Genet1995，10，1： | 1 |
| 16 | Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy显示文摘 | Bandtlow CE Dlaska M Pirker S Czech T Baumgartner C Sperk G | 2004 | Eur J Neurosci2004，20，1： | 1 |
| 17 | Is magnetic resonance imaging useful in guiding the operative approach to large pituitary tumors 显示文摘 | Snow RB Johnson CE Morgello S | 1990 | Neurosurgery1990，26，： | 1 |
| 18 | Subtypes of progressive aphasia:application of the international consensus criteria and validation using B-amyloid imaging显示文摘 | Leyton CE Villemagne VL Savage S | 2011 | Brain2011，134，10： | 1 |
| 19 | Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B显示文摘 | Tacon CE Wiehler S Holden NS | | 0，，： | 1 |
| 20 | Population Pharmacokinetics of Tobramycin in Patients With and Without Cystic Fibrosis显示文摘 | Hennig S Standing JF Staatz CE | | 0，，04： | 1 |
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