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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Failure analysis of low velocity impact on thin composite laminates: ex- perirnental and numerical approaches 显示文摘 | Tia V Carvalho J D Vandepitte D | 2008 | Composite Structures2008，83，： | 1 |
| 3 | Using interpretive structural modelling to identify and rank performance measures: an application supply chain显示文摘 | AZEVEDO S CARVALHO H CRUZ-MACHADO V | 2013 | Baltic Journal of Management2013，8，2： | 1 |
| 4 | Reproductive biology of crocodile shark Pseudocarcharias kamoharai 显示文摘 | OLIVEIRA P HAZIN F H V CARVALHO F | 2010 | Journal of Fish Biology2010，76，7： | 1 |
| 5 | Prognostic impact of p53,C-erbB2 and epidermal growth factor receptor on head and neck carcinoma显示文摘 | PARISE JUNIOR O CARVALHO L V MIGUEL R E | 2004 | Sao Paulo Med J2004，122，： | 1 |
| 6 | 2-Fluorophenol degradation by aerobic granular sludge in a sequencing batch reactor显示文摘 | Duque A F Bessa V S Carvalho M F | 2011 | Water Research2011，45，20： | 1 |
| 7 | The Emerging Role of miR-208a in the Heart显示文摘 | Oliveira-Carvalho V Carvalho VO Bocchi EA | 2013 | DNA Cell Biol2013，32，1： | 1 |
| 8 | Letter:polidocanol sclerotherapy for the treatment of pyogenic granuloma显示文摘 | Carvalho RA Neto V | 2010 | Dermatol Surg2010，2，： | 1 |
| 9 | Dynamic security assessment utilizing the transient energy function method 显示文摘 | EL-KADY M A TANG C K CARVALHO V F | 1984 | IEEE Transactions on Power Systems1984，1，3： | 1 |
| 10 | Detailed analy-sis of expression and promoter methylation status of apop-tosis-related genes in prostate cancer 显示文摘 | Carvalho J R Filipe L Costa V L | 2010 | Apoptosis2010，15，8： | 1 |
| 11 | High carbon dioxide solubilities in trihexyltetradecylphosphonium-based ionic liquids显示文摘 | CARVALHO P J á LVAREZ V H MARRUCHO I M | 2010 | The Journal of Supercritical Fluids2010，52，3： | 1 |
| 12 | Reproducibility of the self controlled six-minute walking test in heart failure patients 显示文摘 | Guimaraes G V Carvalho V O Bocchi E A | 2008 | Clinics2008，63，2： | 1 |
| 13 | Heteroge- nous studies in pulping of wood: Modelling mass transfer of alkali 显示文摘 | Joao P F Simao Ana P V Egas M Graca Carvalho | 2008 | Chemical Engineering Jurnal2008，139，3： | 1 |
| 14 | Role of plant lipid transfer proteins in plant cell physiology-A concise review显示文摘 | Oliveira Carvalho A O Gomes V M | 2007 | Peptides2007，28，： | 1 |
| 15 | Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal显示文摘 | Fernandes J V Meissner R de V Carvalho M G | 2011 | Brazil Mol Med Rep2011，4，6： | 1 |
| 16 | Effect of carbamide peroxide bleaching agents on tensile strength of human enamel显示文摘 | Cavalli V Giannini M Carvalho RM | 2004 | Dental Mater2004，20，8： | 1 |
| 17 | Supercritical fluid extraction from rosemary (Rosmarinus oficinalis):Kinetic data,extract s global yield,composition,and antioxidant activity显示文摘 | Carvalho R N Jr Moura L S Paulo T V Rosa | | 0，，： | 1 |
| 18 | Effect of Halogenated Flame- retardant Additives in the Pyrolysis and Thermal Degradation of Polyester/sisal Composites显示文摘 | FERNANDES V J ARAUJO A S CARVALHO J H | 2005 | Journal of Thermal Analysis and Calorimetry2005，79，2： | 1 |
| 19 | LP models for bin packing and cutting stock problem显示文摘 | Carvalho V | 2002 | European Journal of Operational Research2002，141，2： | 1 |
| 20 | Light microscopical and ultrastructural characterization of goat preantral follicles显示文摘 | LUCCI C M SILVA R V CARVALHO C A | 2001 | Small Rumin Res2001，41，： | 1 |
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