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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer ' s disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 2 |
| 3 | Ridging effects on metting and spreading of liquids on solids显示文摘 | Saiz E Tomsin A P Cannon R M | 1998 | Acta Mater1998，46，7： | 2 |
| 4 | Tree species diversity in commercially logged Bornean rainforest 显示文摘 | Cannon C H Peart D R Leighton M | 1998 | Science1998，281，： | 1 |
| 5 | Efficient implementation of the fuzzy c-means clustering algorithm显示文摘 | Cannon R L Dave J Bezdek J C | 1986 | IEEE Transactions on Pattern Analysis and Machine Intelligence1986，8，2： | 1 |
| 6 | Daily catheter-direct-ed single dosing of t-PA in treatment of acute deep venous thrombosis of the lower extremity显示文摘 | Chang R Cannon RO Chen CC | 2001 | J Vasc Interv Radiol2001，12，： | 1 |
| 7 | Bt transgenic crops: risks and benefits 显示文摘 | Cannon R J C | 2000 | Integrated Pest Management Reviews2000，5，3： | 1 |
| 8 | Stress and decohesion of oxide scales显示文摘 | EVANS A G CANNON R M | 1989 | Materials Science Forum1989，43，3： | 1 |
| 9 | Non-classical H^1-projection and Galerkin methods for nonlinear parabolic integrodifferential equations显示文摘 | Cannon J R Lin Y | 1988 | Calcolo1988，25，3： | 1 |
| 10 | Prognostic utility of apoB/Al, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coro- nary syndromes:results from PROVE IT-TIMI 22 显示文摘 | Ray KK Cannon CP Cairns R | 2009 | Arterioscler Thromb Vasc Biol2009，29，3： | 1 |
| 11 | Classification and nomenclature of viruses of cyanobacteria显示文摘 | Safferman R S Cannon R E Desjardins P R | 1983 | Intervirology1983，19，2： | 1 |
| 12 | Candida albicans: adherence, signaling and virulence 显示文摘 | Calderone R Suzuki S Cannon R | 2000 | Med Mycol2000，38，1： | 1 |
| 13 | Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer' s disease-like neuropathology显示文摘 | Bard F Barbour R Cannon C | 2003 | Proc Natl Acad Sci USA2003，100，4： | 1 |
| 14 | Finite element analysis of the effects of corners on residual stres?ses in protective oxide scales显示文摘 | WRIGHTJ K WILLIAMSON R L CANNON R M | 1997 | Mat Sci Eng (A)1997，230，： | 1 |
| 15 | Sulfate anion in water:model structural,thermodynamic,and dynamic properties显示文摘 | Cannon W R Pettitt B M McCammont J A | 1994 | Journal of Physical Chemistry1994，98，24： | 1 |
| 16 | Surgical resection for hilar cholangiocarcinoma: experience improves resectability 显示文摘 | Cannon R M Brock G Buell J F | 2012 | HPB (Oxford)2012，14，2： | 1 |
| 17 | Prognostie utility of ApoB/AI, total chole- sterol/HDL, non- HDL cholesterol, or hs- CRP as predictors of clinical risk in patients receiving sta- tin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22 显示文摘 | RAY K K CANNON C P CAIRNS R | 2009 | Arterioscler Thromb Vase Biol2009，29，3： | 1 |
| 18 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease 显示文摘 | Bard F Cannon C Barbour R | 2000 | Nature Medicine2000，6，8： | 1 |
| 19 | Aging and stress-induced changes in complement activation and neutrophil mobilization显示文摘 | Cannon J G Fiatarone M A Fielding R A | 1994 | J Appl Physiol1994，76，6： | 1 |
| 20 | Relationship between un- controlled risk factors and C-reactive protein levels in patients re- ceiving standard or intensive statin therapy for acute coronary syn- dromes in the PROVE IT-TIMI 22 trial显示文摘 | Ray KK Cannon CP Cairns R | 2005 | J Am Coil Cmdiol2005，46，8： | 1 |
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