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| 1 | 中国双低油菜饼粕与加拿大卡诺拉粕品质特性的化学评价显示文摘系统地评价了 3个中国双低油菜与加拿大卡诺拉的商品饼粕与脱脂种籽的蛋白质、氨基酸、蔗糖、寡聚糖、饲粮总纤维和灰分等化学特性 ,并对饲粮总纤维的构成成分及加工的影响进行了研究。饲粮总纤维由非淀粉多糖、木质素和多酚、细胞壁蛋白质和矿物质组成。 3个中国双低菜粕的粗蛋白、蔗糖及必需氨基酸含量均接近或高于卡诺拉帕 ,但饲粮总纤维含量显著不同 ,尤其是蛋白质含量由于加工方式不同变异极大。在试验室条件下加工的脱脂种籽样品与相应的饼粕样品相比 ,蔗糖、赖氨酸和饲粮纤维含量变化显著。因此 。 | 彭健 B A Slominsk W Guenter L D Campbell 熊远著 | 2000 | 中国兽医学报2000，20，4： | 16 |
| 2 | 不同加工方式对“双低”菜粕品质的影响显示文摘对 2个不同加工方式生产的中国“双低”菜粕A和B以及 1个加拿大卡诺拉菜粕进行了体外消化和肉鸡饲养及代谢试验 ,以评价其营养价值。体外消化试验结果表明 ,卡诺拉菜粕、样品A和样品B的可消化蛋白质含量分别为 73 .6%、59.0 %和 51 .0 %(P <0 .0 1 ) ;2周的肉鸡生长试验表明 ,试验各期生长速度、采食量和饲料转化率差异显著 (P <0 .0 5)或极显著 (P <0 .0 1 ) ;代谢试验结果表明氮沉积率组间差异显著 (P <0 .0 5)。过热处理时 ,与中性洗涤纤维相连的蛋白质消化率降低 (P <0 .0 1 ) ,是导致氮沉积率低和肉鸡生长性能差的直接原因。试验结果也表明 ,过热处理或热处理不足 ,都对“双低”菜籽饼粕质量产生严重影响。 | 彭健 B A Slominski W Guenter L D Campbell 熊远著 | 2000 | 中国畜牧杂志2000，36，5： | 8 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 5 | QT prolongation is associated with increased mortality in end stage liver disease显示文摘AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and mortality.METHODS The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females.Multiple clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients. | Sun Moon Kim Bennet George Diego Alcivar-Franco Charles L Campbell Richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey | 2017 | World Journal of Cardiology2017，9，4： | 3 |
| 6 | Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy. | Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese | 2013 | Chinese Journal of Cancer2013，32，10： | 3 |
| 7 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 8 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 9 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 10 | Suppression subtractive hybridization:A method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Diatchenko L Lau YF Campbell AP | 1996 | Proc Natl Acad USA1996，93，12： | 2 |
| 11 | Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes显示文摘 | Campbell KN Raij L Mundel P | | Curr Diabetes Rev0，，： | 2 |
| 12 | QT dispersion: an indication of arrhythmia risk in patients with long QT intervals显示文摘 | DAY C P MCCOMB L M Campbell RWF | 1990 | Br Heart J1990，63，： | 1 |
| 13 | Suppression subtractive hy+bridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 14 | Uterine artery embolization:reduced radiation with refined technique显示文摘 | Spies J B Campbell L | 2001 | J Vasc Interv Radiol2001，12，1： | 1 |
| 15 | Production of gene-targeted ship by nuclear transfer from cultured somatic cells显示文摘 | HOWEROF J CAMPBELL K | 2000 | Nature2000，405，6790： | 1 |
| 16 | Physical and chemical characteristics of wood ash 显示文摘 | Etiegnil L Campbell A G | 1991 | Bioresource Technology1991，37，2： | 1 |
| 17 | Microbial ex- pression in soil:methods, applications and challenges 显示文摘 | Saleh L S Miller M Campbell R G | 2005 | Microbiol Methods2005，63，： | 1 |
| 18 | Suppression subtractive hybridization:a method for generating differentially regulated or tissue specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 19 | A survey of QoS architecture显示文摘 | Aurrecoechea C Campbell A Hauw L | 1998 | Multimedia System Journal1998，6，3： | 1 |
| 20 | Semianalytic Monte Carlo radiative transfer model for oceanographic lidar systems 显示文摘 | POOLE L R VENABLE D D CAMPBELL J W | 1981 | Appl Opt1981，20，20： | 1 |
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