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| 1 | CITED2 and the modulation of the hypoxic response in cancer显示文摘CITED2(CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain,2)is a ubiquitously expressed protein exhibiting a high affinity for the CH1 domain of the transcriptional co-activators CBP/p300,for which it competes with hypoxia-inducible factors(HIFs).CITED2 is particularly efficient in the inhibition of HIF-1α-dependent transcription in different contexts,ranging from organ development and metabolic homeostasis to tissue regeneration and immunity,being also potentially involved in various other physiological processes.In addition,CITED2 plays an important role in inhibiting HIF in some diseases,including kidney and heart diseases and type 2-diabetes.In the particular case of cancer,CITED2 either functions by promoting or suppressing cancer development depending on the context and type of tumors.For instance,CITED2 overexpression promotes breast and prostate cancers,as well as acute myeloid leukemia,while its expression is downregulated to sustain colorectal cancer and hepatocellular carcinoma.In addition,the role of CITED2 in the maintenance of cancer stem cells reveals its potential as a target in non-small cell lung carcinoma and acute myeloid leukemia,for example.But besides the wide body of evidence linking both CITED2 and HIF signaling to carcinogenesis,little data is available regarding CITED2 role as a negative regulator of HIF-1αspecifically in cancer.Therefore,comprehensive studies exploring further the interactions of these two important mediators in cancer-specific models are sorely needed and this can potentially lead to the development of novel targeted therapies. | Mónica T Fernandes Sofia M Calado Leonardo Mendes-Silva JoséBraganca | 2020 | World Journal of Clinical Oncology2020，11，5： | 2 |
| 2 | Gemini surfactant-protein interactions:effect of p H,temperature,and surfactant stereochemistry显示文摘 | Faustino C M Calado A R Garcia-Rio L | 2009 | Biomacromolecules2009，10，： | 1 |
| 3 | Effect of ultra-high pressure homogenization on viscosity and shear stress of fermented dairy beverage显示文摘 | MASSON L M P ROSENTHAL A CALADO V M A | 2011 | LWT-Food Science and Technology2011，44，2： | 1 |
| 4 | Hysteretic behavior of dissipative welded fuses for earthquake resistant composite steel and concrete frames 显示文摘 | Calado L Proenca J M Espinha M | 2013 | Steel and Composite Structures2013，14，6： | 1 |
| 5 | Hysteretic behaviour of dissipative bolted fuses for earthquake resistant steel frames 显示文摘 | Calado L Proenqa J M Espinha M | 2013 | Journal of Constructional Steel Research2013，85，： | 1 |
| 6 | Effects of rubber addi-tion to an epoxy resin and its fiber glass-reinforced composite显示文摘 | Sobrinho L L Calado V M A Bastian F L | 2012 | Polymer Composites2012，33，2： | 1 |
| 7 | Efficient and effective dupli- cate detection in hierarchical data显示文摘 | Leitao L Calado P Herschel M | 2013 | IEEE Transactions on Knowledge and Data Engineering2013，25，5： | 1 |
| 8 | Hysteretic behavior of dissipative welded fuses for earthquake resistant composite steel and concrete frames显示文摘 | Calado L Proenca J M Espinha M | 2013 | Steel & Composite Structures2013，14，14： | 1 |
| 9 | Gemini sur- factant - protein interactions : Effect of pH, temperature, and surfactant stereochemistry 显示文摘 | FAUSTINO C M C CALADO A R T GARCIA -RIO L | 2009 | Biomacromolecules2009，10，： | 1 |
| 10 | Link-based similarity measures for the classification of web documents 显示文摘 | Calado P Cristo M Goncalves M A | 2006 | Journal of the American Society for Information Science and Technology2006，57，2： | 1 |
| 11 | Twenty one additional cases of familial renal glucos uria:absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion显示文摘 | Calado J Sznajer Y Metzger D Rita A Hogan M C Kattamis A | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 12 | Dimeric and monomeric surfactmlts derived from sulfur-containing amino acids显示文摘 | Faustino C M C Calado A R T Garcia-Rio L | 2010 | Journal of Colloid and Interface Science2010，351，： | 1 |
| 13 | Familial juvenile nephronophthisis 显示文摘 | Konrad M Saunier S Calado J | 1998 | J Mol Med1998，76，5： | 1 |
| 14 | Cure kinetic parameter estimation of thermosetting resins with isothermal data by using particle swarm optimization 显示文摘 | PAGANO R L CALADO V M A TAVARES F W | 2008 | European Polymer Journal2008，44，8： | 1 |
| 15 | Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia 显示文摘 | Calado RT Regal JA Hills M | 2009 | Proc Natl Acad Sci USA2009，106，4： | 1 |
| 16 | Link-based similarity measure for the classificationdocuments显示文摘 | CALADO P CRISTO M GONCALVES M A | 2006 | Journal of the American Society forInformation Science and Technology2006，57，2： | 1 |
| 17 | A Simple yet Effective Semi-Anechoic Chamber for the Acoustic Characterization of an LSRA显示文摘 | Salvado J A Calado M R Espirito Santo A E | 2013 | Latin America Transactions IEEE2013，11，5： | 1 |
| 18 | Gemini surfactant-protein interactions:effect of p H,temperature,and surfactant stereochemistry显示文摘 | Faustino C M C Calado A R T Garcia-Rio L | 2009 | Biomacromolecules2009，10，9： | 1 |
| 19 | Dimeric and monomeric surfactants derived from sulfur - containing amino acids 显示文摘 | FAUSTINO C M C CALADO A R T GARCIA -RIO L | 2010 | Journal of Colloid and Interface Science2010，351，2： | 1 |
| 20 | Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA显示文摘 | Calado A Treichel N Müller E C | | 0，，22： | 1 |
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