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| 1 | Expression of DNA-dependent protein kinase in human granulocytes显示文摘Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku resulting in enhanced radiation sensitivity. This raises the question if low efficiency of NHEJ, instrumental for the cellular repair of oxidative damage, is a normal characteristic of myeloid differentiation. Here we confirmed the complete lack of DNAPK in P MN protein extracts, and the expression of the truncated Ku86 variant form in HL-60. However, this degradation of DNA-PK was shown to be due to a DNA-PK-degrading protease in PMN and HL-60. In addition, by using a protease-resistant whole cell assay, both Ku86 and DNA-PKcs could be demonstrated in PMN, suggesting the previously reported absence in PMN of DNA-PK to be an artefact. The levels of Ku86 and DNA-PKcs were much reduced in PMN, as compared with that of the lymphocytes, whereas HL-60 displayed a markedly elevated DNA-PK concentration.In conclusion, our findings provide evidence of reduced, not depleted expression of DNA-PK during the mature stages of myeloid differentiation. | Annahita SALLMYR Anna MILLER Aida GABDOULKHAKOVA Valentina SAFRONOVA Gunnel HENRIKSSON Anders BREDBERG | 2004 | Cell Research2004，14，4： | 3 |
| 2 | Bioresource Technology 显示文摘 | Katarina Bredberg B Erik Andersson Eva Landfors | 2002 | 83 : 221 - 2242002，83，： | 1 |
| 3 | Evaluation of coagulase-negative staphylococci in blood cultures:a Prospective clinical and microbiological study显示文摘 | Ringberg H Thoren A Bredberg A | 1991 | Scand J Infect Dis1991，23，3： | 1 |
| 4 | Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole 显示文摘 | Andersson T Rohss K Bredberg E | 2001 | Aliment Pharniacol Ther2001，15，10： | 1 |
| 5 | Tourist perceptions of climate change: A study of international tourists in Zanzibar显示文摘 | Gossling S Bredberg M Randow A | 2006 | Current Issues in Tourism2006，9，45： | 1 |
| 6 | Meningitis following cochlear implantation: pathomechanisms, clinical symptoms, conservative and surgicaltreatments显示文摘 | ARNOLD W G BREDBERG W GSTOTNER J | 2002 | ORL2002，64，： | 1 |
| 7 | Tourist perceptions of climate change: A study of international Tourists in Zanzibar 显示文摘 | Gossling S Bredberg M Randow A | 2006 | Current Issues in Tourism2006，9445，： | 1 |
| 8 | TOF- SIMS analysis of exhaled particles from patients with asthma and healthy controls 显示文摘 | Ahnstrand A C Josefson M Bredberg A | 2012 | Eur Respir J2012，39，1： | 1 |
| 9 | Metabolic stability for drug discovery and development:phar- macokinetic and biochemica challenges显示文摘 | Masimirembwa C M Bredberg U Andersson T B | 2003 | Clin Pharmacokinet2003，42，6： | 1 |
| 10 | Plaster of paris:Thermal properties and biocompatibili-ty显示文摘 | Hogset O Bredberg G | 1986 | Acta otolaryngol1986，101，： | 1 |
| 11 | Pharmacokinetics and effect on pentagastrin stimulated peak acid output (PAO) of omeprazole and its 2 optical isomers,S-omeprazole / esomeprazole and R-omeprazole显示文摘 | Andersson T Bredberg E Sunzel M | 2000 | Gastroenterology2000，，： | 1 |
| 12 | Evaluation of coagulase-negative staphylococci inblood cultures: a prospective clinical and microbiological study显示文摘 | Ringberg H Thoren A Bredberg A | 1991 | Scand J Infect Dis1991，23，3： | 1 |
| 13 | Use of atorvastatin as an anti-inflammatory treatment in Crohn's disease显示文摘 | Grip O Janciauskiene S Bredberg A | 2008 | Br J Pharmacol2008，155，7： | 1 |
| 14 | Pharmacokinetics and pharmacodynamics of esomeprazole,the S-isomer of omeprazole显示文摘 | Andersson T Rohss K Bredberg E | 2001 | Aliment Pharmacol Ther2001，15，10： | 1 |
| 15 | Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions显示文摘 | Bredberg E Andersson TB Frison L | 2003 | Clin Pharmacokinet2003，42，8： | 1 |
| 16 | Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole显示文摘 | Andersson T Rohss K Bredberg E | 2001 | Aliment Pharmacol Ther2001，15，： | 1 |
| 17 | Microbi- al detoxification of waste rubber material by wood-rotting fungi显示文摘 | Bredberg K Andersson B E Landfors E | 2002 | Bioresource Technology2002，83，3： | 1 |
| 18 | Pharmacokinetics and pharmacodynamics of esomeprazole,the S-isomer of omeprazole显示文摘 | ANDERSSON T ROHSS K BREDBERG E el al | 2001 | Aliment Pharmacol Ther2001，15，10： | 1 |
| 19 | CD4^+T lymphocytopenia-a frequent finding in anti-SSA antibody serupositive patients with primary Sjogren's syndrome显示文摘 | Manel T Bredberg A Jacobsson LT | 2004 | J Rheumatol2004，31，4： | 1 |
| 20 | Pharmacokinetics of esomeprazole after oral and intravenous administration of single and repeated doses to healthy subjects显示文摘 | Hassan-Alin M Andersson T Bredberg E | 2000 | Eur J Clin Pharmacol2000，56，910： | 1 |
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