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| 1 | Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis显示文摘AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as controls.RESULTS:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC. | Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein | 2010 | World Journal of Gastroenterology2010，16，8： | 13 |
| 2 | 儿童前庭性偏头痛和儿童复发性眩晕:Bárány协会前庭疾病分类委员会和国际头痛协会诊断标准共识文件显示文摘本文介绍了Bárány协会国际前庭疾病分类(International Classification of Vestibular Disorders,ICVD)委员会和国际头痛协会偏头痛分类小组所提出的'儿童前庭性偏头痛'(vestibular migraine of childhood,VMC)、'很可能的儿童前庭性偏头痛'(probable VMC,pVMC)和'儿童复发性眩晕'(recurrent vertigo of childhood,RVC)的诊断标准。偏头痛在儿童期不同复发性眩晕亚型中起着重要作用。在此分类文件中,VMC、p VMC和RVC这3种与偏头痛相关的一组谱系疾病分类,上述诊断标准中的偏头痛成分为确定、很可能及可能不存在。VMC的诊断标准:(A)至少5次中度或重度前庭症状发作,持续时间5分钟~72小时;(B)当前或既往有伴或不伴先兆的偏头痛病史;(C)至少50%的发作与至少1种偏头痛样症状相关。pVMC的诊断标准:至少3次中度或重度前庭症状发作,持续时间5分钟~72小时,符合VMC诊断标准B或C中的1项。RVC的诊断标准:至少3次中度或重度前庭症状发作,持续时间为1分钟~72小时,VMC诊断标准中的B和C均不符合。对于以上3种疾病,患者的年龄必须<18岁。建议将来的研究应特别关注RVC,以研究和确定其可能的亚型及其与偏头痛的关系。 | 凌霞(译) 张赛(译) 申博(译) 隋汝波(审校) 杨旭(审校) Raymond van de Berg Josine Widdershoven Alexandre Bisdorff Stefan Evers Sylvette Wiener-Vacher Sharon LCushing Kenneth JMack Ji Soo Kim Klaus Jahn Michael Strupp Thomas Lempert | 2021 | 神经损伤与功能重建2021，16，8： | 5 |
| 3 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 4 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 5 | Etiology and Therapeutic Approach to Elevated Lactate显示文摘 | Lars W. Andersen Julie Mackenhauer Jonathan C. Roberts Katherine M. Berg Michael N. Cocchi Michael W. Donnino | 2013 | Mayo Clinic Proceedings2013，，： | 2 |
| 6 | 烟酰胺和N-乙酰葡萄糖胺改善色斑效果观察显示文摘目的:比较含烟酰胺和N-乙酰葡萄糖胺的护肤品在改善色素沉着方面的效果。方法:双盲、基质对照人体试验。采用REAL3.0系统采集所有图像,用相关软件分析色斑面积百分比、L*a*b值、黑素相关的色斑面积百分比、平均黑素含量(灰度)和黑素相关的皮肤颜色均匀度;Chromameter测量非色斑部位皮肤颜色改变;由皮肤科专家分析使用护肤品前后照片改善情况和受试者自我比较进行主观评价。结果:与基质相比,含烟酰胺和N-乙酰葡萄糖胺的护肤品可以抑制色斑面积的增加,减轻紫外线引起的肤色加深和肤色不均匀。结论:正常人皮肤对含烟酰胺和N-乙酰葡萄糖胺的护肤品有良好的耐受性,与基质相比,该护肤品有一定的减轻色素沉着的效果。 | 吴艳 仲少敏 Joe Kaczvinsky 赵俊郁 乔圆 邓琳 Chieko Soh Cindy Berge Michael Marmor Donald Bissett Larry Robinson 朱学骏 | 2007 | 临床皮肤科杂志2007，36，10： | 2 |
| 7 | Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide显示文摘 | Peter E Nielsen Michael Egholm Roll H Berg and Ole Buchardt | 1991 | Science1991，254，5037： | 1 |
| 8 | The role of intraoperative sonography in neurosurgery显示文摘 | Janson M Michael K Berg J | 2005 | J Diag Med Sonography2005，21，2： | 1 |
| 9 | The 2005 world health organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin -like compounds 显示文摘 | Martin Van den Berg Linda S Bimbaum Michael Denison | 2006 | Toxicol Sci2006，93，2： | 1 |
| 10 | Assessing transformation processes of organic contaminants by compound-specific stable isotope analysis显示文摘 | Thomas B. Hofstetter Michael Berg | 2010 | Trends in Analytical Chemistry2010，，4： | 1 |
| 11 | Outcome after liver re‐transplantation in patients with recurrent chronic hepatitis C显示文摘 | Marcus Bahra Ulf Peter Neumann Dietmar Jacob Thomas Berg Ruth Neuhaus Jan Michael Langrehr Peter Neuhaus | 2007 | Transplant International2007，，9： | 1 |
| 12 | Association of lens opacities, intraocular straylight, contrast sensitivity and visual acuity in European drivers 显示文摘 | Michael R van Rijn LJ van den Berg TJ | 2009 | Acta Ophthalmol2009，87，： | 1 |
| 13 | Compound-specific stable isotope analysis of organic contaminants in natural environments: a critical review of the state of the art, prospects, and future challenges显示文摘 | Torsten C. Schmidt Luc Zwank Martin Elsner Michael Berg Rainer U. Meckenstock Stefan B. Haderlein | 2004 | Analytical and Bioanalytical Chemistry2004，，2： | 1 |
| 14 | Straylight effects with aging and lens extraction显示文摘 | Van Den Berg TJ Van Rijn LJ Michael R | | 0，，03： | 1 |
| 15 | Decomposition of red clover (Trifolium pratense) roots显示文摘 | Berg B Michael M Bengt W | 1987 | Soil Biology & Biochemistry1987，19，5： | 1 |
| 16 | Straylight Ef- fects with Aging and Lens Extraction 显示文摘 | Van Den Berg TJ van Rijn LJ Michael R | 2007 | Am J Ophthalmol2007，144，3： | 1 |
| 17 | Decomposition of red clover (Trifolium pratense) roots显示文摘 | BERG B MICHAEL M BENGT W | 1987 | Soil Biology & Biochemistry1987，19，5： | 1 |
| 18 | The role of intraoperative sonography in neurosurgery 显示文摘 | Janson M Michael K Berg J | 2005 | Journal of Diagnostic Medical Sonography2005，21，2： | 1 |
| 19 | Construction and Cost Analysis of an FRP Rein- forced Concrete Bridge Deck显示文摘 | Adam C Berg Lawrence C Bank Michael G Oliva | 2006 | Construction and Building Material2006，20，8： | 1 |
| 20 | Straylight el-fects with aging and lens extraction显示文摘 | Van Den Berg TJ Van Rijn LJ Michael R | 2007 | Am J Ophthalmol2007，144，3： | 1 |
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