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| 1 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 2 | Extraction and HPLC Analysis of Halofuginone in Chicken Serum显示文摘 | Beier R C Rowe L D Abd El-Aziz Nasr M I | 1994 | J Liquid Chromatogr1994，17，13： | 1 |
| 3 | Facile Synthesis of Carboxylic Linker on Halofuginone:A Method to Derivatize Haptens Containing both Amine and Hydroxy Functionalities显示文摘 | Rowe L D Beier R C Elissalde M H | 1993 | Synthetic Conmunications1993，23，15： | 1 |
| 4 | Calculated three dimensional structures of the fumonisin B1-4 mycotoxins 显示文摘 | Beier R C Elissalde M H Stanker L H | 1993 | Bulletin of Environmental Contamination and Toxicology1993，51，3： | 1 |
| 5 | Production and Characterization of Monoclonal Antibodies Against the Poultry Coccidiostat Halofuginone显示文摘 | Rowe L D Beier R C Elissalde M H | 1994 | J Agric Food Chem1994，42，： | 1 |
| 6 | Detection of Halofuginone Residues in Chicken Serum by a Monoclonal-based Immunoassay and High-perfomance Liquid Chromatography显示文摘 | Beier R C Rowe L D Abd El-Aziz Nasr M I | 1996 | Food & Agricultural Immunology1996，8，： | 1 |
| 7 | Fibrin accumulation plays a criti-cal role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice显示文摘 | Beier JI Luyendyk JP Guo L | | 0，，5： | 1 |
| 8 | CAMTA1 is a novel tu- mour suppressor regulated by miR-9/9* in glioblastoma stem cells显示文摘 | Schraivogel D Weinmann L Beier D | 2011 | EMBO J2011，30，20： | 1 |
| 9 | Vagrant and the Social Order in Elizabethan England 显示文摘 | BEIER A L | 1974 | Past and Present1974，，64： | 1 |
| 10 | USDA agricultural research service,detection of bacteria from a cecal anaerobic competitive exclusion culture with an immunoassay electrochemi-luminescence sensor显示文摘 | Beier R C Young C R Stanker L H | 1991 | Proc SPIE1991，35，44： | 1 |
| 11 | Sporogonic development of Plasmodium yoelii in five anopheline species 显示文摘 | Vaughan JA Hensley L Beier JC | 1994 | J Parasitol1994，80，5： | 1 |
| 12 | Survey of susceptibility to cowpea mosaic virus among protoplasts and intact plants from Vigna sinensis lines显示文摘 | Beier H Siler D J Russell M L | 1977 | Phytopathology1977，67，： | 1 |
| 13 | Helios expression is a marker of T cell activation and proliferation 显示文摘 | Akimova T Beier UH Wang L | 2011 | PLo S One2011，6，9： | 1 |
| 14 | Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells显示文摘 | Stanton L A Beier F | 2007 | Exp Cell Res2007，313，1： | 1 |
| 15 | Fibrin accumulation plays a critical role in the sensitization to lipopolysaccha- ride induced liver injury caused by ethanol in mice 显示文摘 | Beier JI Luy endyk JP Guo L | 2009 | Hepatology2009，49，5： | 1 |
| 16 | Helios expression is a marker of T cell activation and proliferation 显示文摘 | Akimova T Beier UH Wang L | 2011 | PLoS One2011，6，24： | 1 |
| 17 | Pharmacokinetics of native Escherichiacoli Aspaaraginase( Asparaginase medac) and hypersensitivity reactions in ALL- BFM 95 reinduction treatment显示文摘 | Muller HJ Beier R Eoning L | 2001 | Br J Haematol2001，114，： | 1 |
| 18 | Experimental manipulations of old pine forest ecosystems to predict the protential tree growth effects of increased CO2 and temperature in a future climate显示文摘 | Rasmussen L Beier C Bergstedt A | 2002 | For Ecol Manag2002，，158： | 1 |
| 19 | Peri-prosthetic femoral fractures treated with the uncemented Wagner revision stem显示文摘 | Marx A Beier A Jung L | 2012 | Hip Int2012，22，3： | 1 |
| 20 | Pharmacokinetics of native Escherichiacoli Aspaaraginase(Asparaginase medac) and hypersensitivity reactions in ALL-BFM 95 reinduction treatment显示文摘 | MULLER HJ BEIER R LONING L | 2001 | Br J Haematol2001，114，： | 1 |
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