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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | Corneal re-innervation following refractive surgery treatments显示文摘Laser refractive surgery is one of the most performed surgical procedures in the world. Although regarded safe and efficient, it has side effects. All of the laser based refractive surgical procedures invoke corneal nerve injury to some degree. The impact of this denervation can range from mild discomfort to neurotrophic corneas. Currently, three techniques are widely used for laser vision correction: small incision lenticule extraction, laser-assisted keratomileusis in situ and photorefractive keratotomy. Each of these techniques affects corneal innervation differently and has a different pattern of nerve regeneration. The purpose of this review is to summarize the different underlying mechanisms for corneal nerve injury and compare the different patterns of corneal reinnervation. | Francisco Bandeira Nur Zahira Yusoff Gary Hin-Fai Yam Jodhbir Singh Mehta | 2019 | Neural Regeneration Research2019，14，4： | 4 |
| 3 | Herb-induced liver injury: Systematic review and meta-analysis显示文摘BACKGROUND The use of herbal supplements and alternative medicines has been increasing in the last decades.Despite popular belief that the consumption of natural products is harmless,herbs might cause injury to various organs,particularly to the liver,which is responsible for their metabolism in the form of herb-induced liver injury(HILI).AIM To identify herbal products associated with HILI and describe the type of lesion associated with each product.METHODS Studies were retrieved using Medical Subject Headings Descriptors combined with Boolean operators.Searches were run on the electronic databases Scopus,Web of Science,MEDLINE,BIREME,LILACS,Cochrane Library for Systematic Reviews,SciELO,Embase,and Opengray.eu.Languages were restricted to English,Spanish,and Portuguese.There was no date of publication restrictions.The reference lists of the studies retrieved were searched manually.To access causality,the Maria and Victorino System of Causality Assessment in Drug Induced Liver Injury was used.Simple descriptive analysis were used to summarize the results.RESULTS The search strategy retrieved 5918 references.In the final analysis,446 references were included,with a total of 936 cases reported.We found 79 types of herbs or herbal compounds related to HILI.He-Shou-Wu,Green tea extract,Herbalife,kava kava,Greater celandine,multiple herbs,germander,hydroxycut,skullcap,kratom,Gynura segetum,garcinia cambogia,ma huang,chaparral,senna,and aloe vera were the most common supplements with HILI reported.Most of these patients had complete clinical recovery(82.8%).However,liver transplantation was necessary for 6.6%of these cases.Also,chronic liver disease and death were observed in 1.5%and 10.4%of the cases,respectively.CONCLUSION HILI is normally associated with a good prognosis,once the implied product is withdrawn.Nevertheless,it is paramount to raise awareness in the medical and non-medical community of the risks of the indiscriminate use of herbal products. | Vinícius Remus Ballotin Lucas Goldmann Bigarella Ajacio Bandeira de Mello Brandão Raul Angelo Balbinot Silvana Sartori Balbinot Jonathan Soldera | 2021 | World Journal of Clinical Cases2021，9，20： | 4 |
| 4 | Low platelet count: Predictor of death and graft loss after liver transplantation显示文摘BACKGROUND The impact of platelets on liver transplantation(LT) is well recognized, but not completely understood. Platelets exert dichotomous effects on the graft and on the patient. On the one hand, they are essential for primary hemostasis and tissue repair and regeneration. On the other hand, they support ischemia/reperfusion injury and inflammatory processes. Recent evidence has shown a new role for platelet count(PC) in predicting outcomes after LT.AIM To evaluate if low PC is a predictor of short-and long-term outcomes after LT.METHODS Four hundred and eighty consecutive LT patients were retrospectively assessed.PC from the preoperative to the seventh postoperative day(POD) were considered. C-statistic analysis defined the ideal cutoff point for PC. Cox regression was performed to check whether low PC was a predictor of death,retransplantation or primary changes in graft function within one year after LT.RESULTS The highest median PC was 86 × 109/L [interquartile range(IQR) = 65–100 ×109/L] on seventh POD, and the lowest was 51 × 109/L(IQR = 38–71 × 109/L) on third POD. The C-statistic defined a PC < 70 × 109/L on fifth POD as the ideal cutoff point for predicting death and retransplantation. In the multivariate analysis, platelets < 70 × 109/L on 5 POD was an independent risk factor for death at 12 mo after LT [hazard ratio(HR) = 2.01; 95% confidence interval(CI) 1.06-3.79;P = 0.031]. In the Cox regression, patients with PC < 70 × 109/L on 5 POD had worse graft survival rates up to one year after LT(HR = 2.76; 95%CI 1.52-4.99; P =0.001).CONCLUSION PC < 70 × 109/L on 5 POD is an independent predictor of death in the first year after LT. These results are in agreement with other studies that indicate that low PC after LT is associated with negative outcomes. | Pedro Beltrame Santiago Rodriguez Ajacio Bandeira de Mello Brand?o | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 5 | Se-lective inhibition of C0X-2 improves cutaneous wound healingof pressure ulcers in mice through reduction of iNOS expres-sion显示文摘 | Romana-Souza B dos Santos J S Bandeira L G | 2016 | Life Sci2016，153，： | 1 |
| 6 | Endovascular treatment of anterior choroidal artery aneurysms显示文摘 | Senturk C Bandeira A Bruneau M | 2009 | J Neuroradiol2009，36，4： | 1 |
| 7 | Metabolic Syndrome and Central Fat Distribution Are Related to Lower Serum Osteocalcin Concentrations显示文摘 | Bezerra Dos Santos Magalh?es Karina Moreira Magalh?es Marcelo Trov?o Diniz Erik Salgado Lucena Cynthia Griz Luiz Bandeira Francisco | 2013 | Annals of Nutrition & Metabolism2013，，3： | 1 |
| 8 | Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats显示文摘 | Carvalho F Macedo D Bandeira I | 2002 | Horm Metab Res2002，34，2： | 1 |
| 9 | Mycotic aneurysm caused by Burkholderia pseudomallei:report of a Brazilian strains显示文摘 | Sidrim JJC Rocha MFG Bandeira TJPG | | 0，，09： | 1 |
| 10 | Emerging role of dipeptidyl peptidase -4 inhibitors in the management of type 2 diabetes显示文摘 | Richter B Bandeira - Echtler E Bergerhoff K | 2008 | Vascular Health and Risk Management2008，4，： | 1 |
| 11 | A DSS for inte- grated distribution of empty and full containers显示文摘 | Bandeira D L Becket J L Borenstein D | 2009 | Decision Support Systems2009，47，4： | 1 |
| 12 | Influence of thermal or chemical degradation on the frictional force of an experimental coated NiTi wire 显示文摘 | Bandeira A M dos Santos M P Pulitini G | 2011 | Angle Orthod2011，81，3： | 1 |
| 13 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 14 | The Sulphur Oxygenase Reductase from Acidianus Ambivalens is a Multimeric Protein Containing a Lowpotential Mononuclear Non-haem Iron Centre显示文摘 | Urich T Bandeiras TM Leal SS | 2004 | Biochem2004，381，1： | 1 |
| 15 | Compression, shear and bending on tissue-engineered cartilage: a numerical study显示文摘 | Bandeiras C Completo A Ramos A | 2014 | Comput Method Biomec2014，17，1： | 1 |
| 16 | Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva allemǎo显示文摘 | Viana GS Bandeira MA Matos FJ | 2003 | Phytomedicine2003，10，： | 1 |
| 17 | A Method for Evacuation Route Planning in Disaster Situations显示文摘 | Campos V Bandeira R Bandeira A | 2012 | Procedia - Social and Behavioral Sciences2012，54，2290： | 1 |
| 18 | Stenting is improving and stabilizing anatomical results of coiled intracrarial aneurysms显示文摘 | Lubicz B Bandeira A Bruneau M | | 0，，06： | 1 |
| 19 | High prevalence of giardiasis and strong lyloidiasis among HIV-infected patients in Bahia, Brazil显示文摘 | Feitosa GA Bandeira C Sampaio DP | 2001 | Braz J Infect Dis2001，5，6： | 1 |
| 20 | Stenting is improving and stabilizing anatomical results of coiled intracranial aneurysms显示文摘 | Lubicz B Bandeira A Bruneau M | 2009 | Neu-roradiology2009，51，6： | 1 |
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