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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Squamous cell carcinoma of the thyroid 显示文摘 | Bal S Arunabb J | 1988 | J Surg Onco1988，39，1： | 1 |
| 3 | What′s new in total hip arthroplasty显示文摘 | Huo MH Parvizi J Bal BS | 2009 | J Bone Joint Surg2009，91，10： | 1 |
| 4 | Mouse beta-defensin is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogential tract显示文摘 | Bals R Goldman M J Wilson J M | 1998 | Infect Immun1998，63，3： | 1 |
| 5 | Influence of hBN content on mechanical and tribological properties of Si3N4/ BN ceramic composites 显示文摘 | KovalcKov A Balko J Bal zsi C | 2014 | J Eur Ceram Soc2014，34，： | 1 |
| 6 | Nigrostriatal neuronal death following chronic dichlorvos exposure:crosstalk between mitochondrial impairments,or synuclein aggregation,oxidative damage and behavioral changes 显示文摘 | Binukumar BK Bal A Kandimalla R J | 2010 | Mol Brain2010，3，： | 1 |
| 7 | Multi- metal binding site of serum albumin 显示文摘 | BAL W CHRISTODOULOU J SADLER P J | 1998 | J Inorg Bio- chem1998，70，： | 1 |
| 8 | Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischemia in rats显示文摘 | De Cristóbal J Moro AM Dávalos A | | 0，，02： | 1 |
| 9 | Experimental study of ra- diative heat transfer in a translucent fuel sample exposed to different spectral sources 显示文摘 | Bal N Raynard J Rein G | 2013 | International Journal of Heat and Mass Transfer2013，61，： | 1 |
| 10 | Noninvasive assessment of myocardial viability in a small animal model:comparison of MRI,SPECT,and PET显示文摘 | Thomas D Bal H Arkles J | | 0，，： | 1 |
| 11 | Mouse β-defensin 1 is asalt-sensitive antimicrobial peptide present in epithelia of thelung and urogenital tract 显示文摘 | Bals R Goldman M J Wilson J M | 1998 | Infection and Immunity1998，66，： | 1 |
| 12 | A review of ceramic bearing materials in total joint arthroplasty显示文摘 | Bal BS Garino J Ries M | | 0，，01： | 1 |
| 13 | Competition between Sec‐and TAT-dependent protein translocation in Escherichia coli显示文摘 | Cristóbal S de Gier J W Nielsen H | 1999 | The EMBO journal1999，18，11： | 1 |
| 14 | A unified approach to superresolution and multichannel blind deconvolution显示文摘 | Sroubek F Cristóbal G Flusser J | 2007 | IEEE Tram on Image Processing2007，16，9： | 1 |
| 15 | The high-molecular-weight cytochrome c Cyc2 of Acidithiobacillus ferrooxidans is an outer membrane protein显示文摘 | Yarzábal A Brasseur G Ratouchniak J | 2002 | The Journal of Bacteriology2002，184，： | 1 |
| 16 | C1-C2 posterior fixation: are 4 screws better than 2 ? 显示文摘 | Vergara P Bal J S Hickman C A | 2012 | Neurosurgery2012，71，1： | 1 |
| 17 | Leiomyosarcoma of the female breast显示文摘 | Eszter Székely L. Madaras Janina Kulka Balázs Járay Lajos Nagy | 2001 | Pathology Oncology Research2001，，2： | 1 |
| 18 | The influence of surface modification on the structure and properties of a nanosilica filled thermoplastic elastomer显示文摘 | Aso O Eguiza' Bal J I Nazabal J | 2007 | Composites Science and Technology2007，67，： | 1 |
| 19 | Impact of the matur ity of co rn for use as silage in the diets of dairy cow on intake, dig estio n and milk production显示文摘 | Bal M A Gcoors J G Shaver R D | 1997 | Journal of Dairy Science1997，，80： | 1 |
| 20 | Application of small interfering RNA(si RNA)for modulation of airway epithelial gene expression显示文摘 | Platz J Pinkenburg O Beisswenger C Püchner A Damm T Bals R | 2005 | Oligonucleotides2005，15，2： | 1 |
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