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| 1 | Apoptosis and the target genes of microRNA-21显示文摘MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis.This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21. | Lindsey E.Becker Buscaglia | 2011 | Chinese Journal of Cancer2011，30，6： | 49 |
| 2 | MicroRNAs in NF-κB signaling显示文摘Nuclear factor κB(NF-κB)is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity,cell proliferation,inflammation,and tumor development.MicroRNAs(miRNAs)are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3′untranslated regions of mRNAs.In this work,we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases,particularly in cancer.The function of miR-146,miR-155,miR-181b,miR-21,and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed.Given that over 1000 human miRNAs have been identified,rendering miRNAs one of the most abundant classes of regulatory molecules,deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer. | Xiaodong Ma Lindsey E.Becker Buscaglia Juanita R.Barker Yong Li | 2011 | Journal of Molecular Cell Biology2011，3，3： | 3 |
| 3 | Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract显示文摘 | Jonathan M. Buscaglia Satish Nagula Vijay Jayaraman David H. Robbins Deepak Vadada Seth A. Gross Christopher J. DiMaio Shireen Pais Kal Patel Divyesh V. Sejpal Michelle K. Kim | 2012 | Gastrointestinal Endoscopy2012，，6： | 3 |
| 4 | Prospective evaluation of the long-term outcomes after deep small-bowel spiral enteroscopy in patients with obscure GI bleeding显示文摘 | J. Blair Williamson Joel R. Judah Jill K.J. Gaidos Dennis P. Collins Mihir S. Wagh Shailendra S. Chauhan Shabnam Zoeb Jonathan M. Buscaglia Hui Yan Wei Hou Peter V. Draganov | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 5 | Diagnostic Yield of Spiral Enteroscopy When Performed for the Evaluation of Abnormal Capsule Endoscopy Findings显示文摘 | Jonathan M. Buscaglia Robert Richards Mark N. Wilkinson Joel R. Judah Yvette Lam Satish Nagula Peter V. Draganov | 2011 | Journal of Clinical Gastroenterology2011，，4： | 2 |
| 6 | Elemental analysis of small glass fragments in forensic science显示文摘 | Buscaglia JA | | 0，，1： | 1 |
| 7 | Incorpo-rati0n of Er^3+ into BaTiO3 显示文摘 | BUSCAGLIA M T VIVIANI M BUSCAGLIA V | 2002 | JAm Ceram Soc2002，85，： | 1 |
| 8 | EUS-guided portal vein catheterization:a promising novel approach for portal angiography and portal vein pressure measurements显示文摘 | Giday SA Clarke JO Buscaglia JM | 2008 | Gastrointest Endosc2008，67，2： | 1 |
| 9 | Size and shape control of SrTiO3 particles grown by epitaxial self-assembly显示文摘 | CALDERONE V R TESTINO A BUSCAGLIA M T | 2006 | Chem Mater2006，18，6： | 1 |
| 10 | Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite显示文摘 | Singh AP Buscaglia CA Wang Q | 2007 | Cell2007，131，3： | 1 |
| 11 | Allergic subjects express intercellular adhesion molecule-1(ICAM-1 or CD54)on epithelial cells of conjunctiva after allergen challenge显示文摘 | Ciprandi G Buscaglia S Pesce G | 1993 | J Allergy Clin Immunol1993，91，3： | 1 |
| 12 | Modeling the interaction between aldolase and the throm- bospondin-related anonymous protein,a key connection of the malaria parasite invasion machinery 显示文摘 | BUSCAGLIA C A HOL W G J NUSSENZWEIG V | 2007 | Proteins2007，66，3： | 1 |
| 13 | Decomposition of Al2TiO5 and Al2(1-x)? MgxTi(1+x)O5 ceramics 显示文摘 | BUSCAGLIA V NANNI P | 1998 | J Am Ceram Soc1998，81，： | 1 |
| 14 | The practice of evidence-based medicine(EBM) in gastroenterology:discrepancies between EBM familiarity and EBM competency显示文摘 | Buscaglia J Nagula S Yuan J | 2011 | Therap Adv Gastroentero2011，4，5： | 1 |
| 15 | Raman and AFM piezoresponse study of dense BaTiO3 nanocrystalline ceramics显示文摘 | BUSCAGLIA V BUSCAGLIA M T VIVIANI M et a1 | 2005 | J Eur Ceram Soc2005，25，： | 1 |
| 16 | Early detection of cotton leaf nitrogen status using leaf reflectance 显示文摘 | Buscaglia H J Varco J J | 2002 | Journal of Plant Nutrition2002，25，9： | 1 |
| 17 | High dieiectric constant and frozen macroscopic polarization in dense nanocrystalline BaTiO3 ceramics 显示文摘 | Buscaglia M T Viviani M Buscaglia V | 2006 | Physical Review B2006，73，： | 1 |
| 18 | Finite element modeling of liquid deuteriumflow and heat transfer in a cold-neutron source显示文摘 | BUSCAGLIA G C DARI E A MARTIN J E | 2004 | Int J Comput Fluid D2004，18，5： | 1 |
| 19 | The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video)显示文摘 | J. Buscaglia K. Dunbar P. Okolo J. Judah P. Akerman D. Cantero P. Draganov | 2009 | Endoscopy2009，，03： | 1 |
| 20 | Acute pancreatitis显示文摘 | MUNSELL M A BUSCAGLIA J M | 2010 | Journal of Hospital Medicine2010，5，： | 1 |
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